Cell Metabolism

产品 1 到 50 共 394个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
  1. Clarithromycin

    Catalog No. A10225
    Quick View
    cytochrome P4503A4 抑制剂
    Clarithromycin是一种大环内酯类抗生素。它通过干扰细菌的蛋白质合成来防止细菌生长。 了解更多
  2. Haloperidol (Haldol)

    Catalog No. A10446
    Quick View
    CYP2D6 抑制剂
    Haloperidol (Haldol)是一种抗精神病药和丁二酮。 了解更多
  3. Talarozole R enantiomer

    Catalog No. A13113
    Quick View
    Cytochrome P450 抑制剂
    Talarozole R enantiomer 通过阻断细胞色素P450酶同工酶CYP26(一种视黄酸羟化酶)来抑制视黄酸的代谢。 了解更多
  4. Efavirenz

    Catalog No. A15826
    Quick View
    cytochrome P450 抑制剂
    Efavirenz是一种非核苷类逆转录酶抑制剂(NNRTI)。 了解更多
  5. Sulfaphenazole

    Catalog No. A17283
    Quick View
    CYP2C9 inhibitor
    Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. 了解更多
  6. CYP17-IN-1

    Catalog No. A12622
    Quick View
    CYP17 inhibitor
    CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. 了解更多
  7. Bergaptol

    Catalog No. A12303
    Quick View
    CYP3A4 enzyme inhibitor
    Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. 了解更多
  8. Liarozole dihydrochloride

    Catalog No. A21853
    Quick View
    CYP450 dependent inhibitor
    Liarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多
  9. Seviteronel

    Catalog No. A20996
    Quick View
    CYP17 lyase inhibitor
    Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多
  10. Veledimex

    Catalog No. A21011
    Quick View
    CYP3A4/5 inhibitor and substrate
    Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. 了解更多
  11. TAK-700 (Orteronel)

    Catalog No. A11044
    Quick View
    CYP17A1 抑制剂
    TAK-700 (Orteronel)是一种口服非甾体雄激素合成抑制剂,可选择性抑制17,20裂解酶。 了解更多
  12. Voriconazole (Vfend)

    Catalog No. A10978
    Quick View
    CYP17 抑制剂
    Voriconazole (Vfend)是一种三唑抗真菌剂,可以冻干粉的形式用于静脉输注溶液。 了解更多
  13. Abiraterone (CB-7598)

    Catalog No. A10020
    Quick View
    CYP17 抑制剂
    Abiraterone (CB-7598)是一种有效CYP17抑制剂,20裂合酶(CYP17A1)。 了解更多
  14. Abiraterone Acetate (CB7630)

    Catalog No. A11058
    Quick View
    CYP17 抑制剂
    Abiraterone Acetate是Abiraterone的醋酸盐形式,是一种甾体类细胞色素CYP17抑制剂。 了解更多
  15. Avasimibe (CI-1011)

    Catalog No. A10102
    Quick View
    CYP17 抑制剂
    Avasimibe (CI-1011)是口服可生物利用的酰基辅酶A:胆固醇O-酰基转移酶(ACAT)抑制剂,IC50分别为2.9 μM, 13.9 μM和26.5 μM。 了解更多
  16. TOK-001 (Galeterone)

    Catalog No. A11138
    Quick View
    CYP17 抑制剂
    TOK-001 (Galeterone)既是雄激素受体拮抗剂又是CYP17A1抑制剂。 了解更多
  17. Alizarin

    Catalog No. A10054
    Quick View
    CYP17 抑制剂
    Alizarin 在生物学研究中被新颖地用作染色剂,因为它可以将游离钙和某些钙化合物染成红色或浅紫色。 了解更多
  18. Apigenin

    Catalog No. A10081
    Quick View
    Protein kinase 抑制剂
    Apigenin是中央苯并二氮杂central受体的配体,其Ki为4μM竞争性抑制氟硝西epa的结合,发挥抗焦虑和轻微的镇静作用。 了解更多
  19. Baicalein

    Catalog No. A10120
    Quick View
    Lipoxygenase 抑制剂
    Baicalein是一种类黄酮,最初从黄cut的根中分离出来。Baicalein抑制脂质过氧化 (通过TBARS的产生评估),IC50值为5 ?M。 了解更多
  20. Posaconazole

    Catalog No. A10744
    Quick View
    CYP3A4 抑制剂
    Posaconazole主要是CYP3A4的抑制剂,但不抑制其他CYP酶的活性。也是甾醇C14+脱甲基酶抑制剂的抑制剂,IC50为0.25μM。泊沙康唑的终末消除半衰期中位数为15-35小时。 了解更多
  21. Ketoconazole

    Catalog No. A10498
    Quick View
    P450 抑制剂
    ketoconazole作为抗真菌药在结构上类似于咪唑,并干扰真菌细胞膜组成成分麦角甾醇以及某些酶的真菌合成。 了解更多
  22. Cobicistat (GS-9350)

    Catalog No. A11277
    Quick View
    CYP3A 抑制剂
    Cobicistat (GS-9350)是有效,选择性的细胞色素酶P450 3A (CYP3A)抑制剂,包括重要的cyp3a4亚型。它还抑制肠道转运蛋白,增加几种hiv药物的整体吸收,包括atazanavir、darunavir和tenofovir alafenamide延胡索酸盐。 了解更多
  23. PF 4981517

    Catalog No. A12544
    Quick View
    CYP3A4 抑制剂
    PF 4981517是一种有效且选择性的CYP3A4抑制剂(CYP3A4,CYP3A5和CYP3A7的IC50值分别为0.03、17和70 μM)。 了解更多
  24. Ozagrel(OKY-046)

    Catalog No. A10688
    Quick View
    TXAS 抑制剂
    Ozagrel(OKY-046)是一种有效的选择性血栓烷A2合成酶抑制剂,IC50为4 nM。 了解更多
  25. ABT

    Catalog No. A13361
    Quick View
    Cytochrome P450 抑制剂
    ABT (1-Aminobenzotriazole)是(CYP)细胞色素P-450和氯过氧化物酶的自杀底物。 了解更多
  26. TAK-700 Salt (Orteronel Salt)

    Catalog No. A13515
    Quick View
    CYP17A1/androgen synthesis 抑制剂
    TAK-700 Salt (Orteronel Salt)是一种雄激素合成抑制剂。它选择性地抑制在睾丸,肾上腺和前列腺肿瘤组织中表达的酶CYP17A。 了解更多
  27. Choline Fenofibrate

    Catalog No. A15044
    Quick View
    CYP2C19/CYP2B6 抑制剂
    Choline Fenofibrate (ABT-335)是非诺贝特酸的胆碱盐,与瑞舒伐他汀联合用于治疗血脂异常。 了解更多
  28. Azathramycin

    Catalog No. A15010
    Quick View
    CYP3A4 抑制剂
    Azathramycin是一种抗生素。阿奇霉素与细菌核糖体的50S亚基结合,从而抑制mRNA的翻译。 了解更多
  29. Benzbromarone

    Catalog No. A16201
    Quick View
    CYP2C9 抑制剂
    Benzbromarone是一种CYP2C9抑制剂,它以19.3 nM的Ki值与CYP2C9结合。 了解更多
  30. Vinpocetine

    Catalog No. A11602
    Quick View
    PDE1 抑制剂
    Vinpocetine是一种Ca2+钙调蛋白依赖性磷酸二酯酶I(PDE1)抑制剂。 了解更多
  31. Cilostamide

    Catalog No. A13596
    Quick View
    PDE3 抑制剂
    Cilostamide是磷酸二酯酶(PDE)3A和PDE3B的选择性抑制剂,IC50值分别为27和50 nM。 了解更多
  32. MK-0359

    Catalog No. A13467
    Quick View
    PDE4 抑制剂
    MK-0359是一种选择性和有效的口服PDE4抑制剂,用于慢性哮喘。 了解更多
  33. GSK256066 2,2,2-trifluoroacetic acid

    Catalog No. A15097
    Quick View
    PDE 抑制剂
    GSK256066是一种选择性PDE4B(与A-D型同等亲和力)抑制剂,IC50为3.2 pM,对PDE1/2/3/5/6的选择性> 380,000倍,对PDE4B与PDE7的选择性> 2500倍。 了解更多
  34. Nortadalafil

    Catalog No. A15191
    Quick View
    PDE5 抑制剂
    Nortadalafil是去甲基他达拉非,它是一种PDE5抑制剂,目前以药丸形式销售,用于治疗勃起功能障碍(ED),名称为Cialis。并以Adcirca为名,用于治疗肺动脉高压。 了解更多
  35. Oglemilast

    Catalog No. A15197
    Quick View
    PDE4 抑制剂
    Oglemilast是PDE4的有效抑制剂。 了解更多
  36. Olprinone Hydrochloride

    Catalog No. A15198
    Quick View
    PDE3 抑制剂
    Olprinone Hydrochloride是一种选择性磷酸二酯酶3(PDE3)抑制剂。 了解更多
  37. TAK-063

    Catalog No. A15799
    Quick View
    PDE10A 抑制剂?
    TAK-063是一种高效,选择性和口服活性的PDE10A抑制剂,IC50为0.30 nM。选择性是其他PDE的15000倍以上。 了解更多
  38. Sildenafil

    Catalog No. A12631
    Quick View
    PDE5 抑制剂
    Sildenafil是选择性磷酸二酯酶5(PDE5)抑制剂之一(IC50 = 5.22 nM),被认为是治疗勃起功能障碍的最佳方法。 了解更多
  39. PDE-9 inhibitor

    Catalog No. A11532
    Quick View
    PDE-9 inhibitor
    PDE-9 inhibitor is useful for neurodegenerative diseases. 了解更多
  40. AN3199

    Catalog No. A12228
    Quick View
    PDE4 inhibitor
    AN3199 is a PDE4 inhibitor with IC50 of 94.5 nM. 了解更多
  41. PF-05180999

    Catalog No. A13006
    Quick View
    PDE2A inhibitor
    PF-05180999 is a phosphodiesterase 2A (PDE2A) inhibitor, with an IC50 of 1.6 nM. 了解更多
  42. BI-409306

    Catalog No. A12970
    Quick View
    PDE9A inhibitor
    BI-409306 is a potent and selective PDE9A inhibitor, with an IC50 of 52 nM. 了解更多
  43. Sildenafil citrate

    Catalog No. A10841
    Quick View
    PDE5 inhibitor
    Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM. 了解更多
  44. Mirodenafil dihydrochloride

    Catalog No. A18047
    Quick View
    PDE-5 inhibitor
    Mirodenafil dihydrochloride (SK3530 dihydrochloride) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多
  45. D159687

    Catalog No. A21228
    Quick View
    PDE4D inhibitor
    D159687 is a selective PDE4D inhibitor. 了解更多
  46. PF-04957325

    Catalog No. A21246
    Quick View
    PDE8 inhibitor
    PF-04957325 is a highly potent and selective PDE8 inhibitor, with IC50s of 0.7 nM and 0.3 nM for PDE8A and PDE8B, respectively. 了解更多
  47. Mirodenafil

    Catalog No. A21260
    Quick View
    PDE-5 inhibitor
    Mirodenafil(SK3530) is a phosphodiesterase type 5 (PDE-5) inhibitor developed for the treatment of erectile dysfunction. 了解更多
  48. Saterinone hydrochloride

    Catalog No. A21402
    Quick View
    PDE3 inhibitor
    Saterinone hydrochloride is a phosphodiesterase III (PDE III) inhibitor. 了解更多
  49. ITI214

    Catalog No. A21422
    Quick View
    PDE1 inhibitor
    ITI-214 is a picomolar PDE1 inhibitor with excellent selectivity against other PDE family members and against a panel of enzymes, receptors, transporters, and ion channels, exhibits potent PDE1 inhibitory activity (Ki = 58 pM). 了解更多
  50. AMG 579

    Catalog No. A21478
    Quick View
    PDE10A inhibitor
    AMG 579 is a potent, selective, and efficacious inhibitor of phosphodiesterase 10A (PDE10A) with an IC50 of 0.1 nM. 了解更多

产品 1 到 50 共 394个

每页
页面:
  1. 1
  2. 2
  3. 3
  4. 4
  5. 5

设置升序顺序
Rewards