FLT3

Inhibitory Selectivity

Catalog No.	Inhibitor Name	FLT3	Other
A10996	Cabozantinib	**	VEGFR2/KDR,c-Met,Kit
A10027	Quizartinib	***
A11411	Dovitinib	****	c-Kit,VEGFR3/FLT4,FGFR1
A10610	Amuvatinib	*	c-Kit (D816H),PDGFRα (V561D)
A10887	Tandutinib	*	c-Kit,PDGFRβ,CSF-1R
A11180	TG101209	*	JAK2,RET,JAK3
A10508	KW-2449	****	Abl (T315I),Abl,FGFR1
A10352	ENMD-2076	***	RET,Aurora A,VEGFR3/FLT4
A10198	Dovitinib Dilactic Acid	****	c-Kit,FGFR1,VEGFR3/FLT4
A12694	Pacritinib	**	JAK2 (V617F),JAK2,TYK2
A12427	TCS 359	*
A10352	ENMD-2076 L-(*)-Tartaric acid		RET,Aurora A,VEGFR3/FLT4
A15904	UNC2025	****	Mer
A14025	AMG 925	****	CDK4,CDK1
A14214	G-749	****	Mer,Aurora B,RET
A14156	AZD2932		PDGFRβ,VEGFR-2,c-Kit
A10769	R406		Syk
A12419	Go6976		JAK2,PKCα,PKCβ1
A11962	TG-02 (SB1317)	*	CDK2, JAK2
A14411	Gilteritinib (ASP2215)	****	Axl
A15003	AST 487		Ret, c-Kit, KDR, c-Abl
A15520	Pexidartinib (PLX3397)	*	Kit, CSF-1R
A15548	SU5614
A16248	BPR1J-097	**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

Catalog No.	Product Name	Application	Product Information
A10027 SALE	AC220 (Quizartinib)	FLT3 抑制剂	AC220 (Quizartinib) is a uniquely potent and selective FLT3 inhibitor with IC50 of 0.56 ± 0.3 nM and >10 mM for MC4-11 and A375, respectively. Product Citations (3) N Naganna, .et al. Amino alkynylisoquinoline and alkynylnaphthyridine compounds potently inhibit acute myeloid leukemia proliferation in mice, EBioMedicine, 2019, Jan 24. pii: S2352-3964(19)30012-X PMID: 30686755 Cong Li, .et al. AMG 925 is a dual FLT3/CDK4 inhibitor with the potential to overcome FLT3 inhibitor resistance in acute myeloid leukemia., Mol Cancer Ther., 2015, Feb;14(2):375-83. PMID: 25487917 Yaping Zhang, .et al. FLT3 and CDK4/6 inhibitors: Signaling mechanisms and tumor burden in subcutaneous and orthotopic mouse models of acute myeloid leukemia, J Pharmacokinet Pharmacodyn., 2014, 41(6): 675每691. PMID: 25326874
A14156	AZD 2932	mutil-targeted protein tyrosine kinase 抑制剂	AZD2932 is a potent and mutil-targeted protein tyrosine kinase inhibitor with IC50 of 8 nM, 4 nM, 7 nM, and 9 nM for VEGFR-2, PDGFRβ, Flt-3, and c-Kit, respectively.
A11962 SALE	TG-02 (SB1317)	FLT3 抑制剂	TG-02 is a novel small molecule potent CDK/JAK2/FLT3 inhibitor.
A14214	G-749	FLT3 抑制剂	G-749 is a novel and potent FLT3 inhibitor with IC50 of 0.4 nM, 0.6 nM and 1 nM for FLT3 (WT), FLT3 (D835Y).
A14411	Gilteritinib (ASP2215)	FLT3/Axl 抑制剂	Gilteritinib is a potent FLT3/AXL inhibitor, which showed potent antileukemic activity against AML with either or both FLT3-ITD and FLT3-D835 mutations.
A14025	AMG-925	Dual FLT3/CDK4 抑制剂	AMG-925 is a potent, selective, and bioavailable FLT3/cyclin-dependent kinase 4 (CDK4) dual kinase inhibitor.
A15003	AST 487	RET kinase 抑制剂	AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
A15520 SALE	Pexidartinib (PLX3397)	CSF1/Kit/FLT3 抑制剂	Pexidartinib is a small-molecule receptor tyrosine kinase (RTK) inhibitor of KIT, CSF1R and FLT3 with potential antineoplastic activity.
A15548 SALE	SU5614	FLT3 抑制剂	SU5614 is a potent and selective FLT3 inhibitor. SU5614 reverts the antiapoptotic and pro-proliferative activity of FLT3 ligand (FL) in FL-dependent cells.
A15904	UNC-2025	Dual MER/FLT3 抑制剂	UNC-2025 is a potent and orally bioavailable dual MER/FLT3 inhibitor with IC50 of 0.74 nM and 0.8 nM, respectively, about 20-fold selectivity over Axl and Tyro3.
A16246	AC710 Mesylate	FLT3/KIT/PDGFR??/PDGFR?? 抑制剂	AC710 Mesylate is a potent, selective PDGFR-family kinases inhibitor with Kd values of 0.6 nM/1.0 nM/1.3 nM/1.0 nM for FLT3/KIT/PDGFRα/PDGFRβ respectively.
A16248	BPR1J-097	FLT3 抑制剂	BPR1J-097 is a novel small molecule FLT-3 inhibitor with promising in vivo anti-tumour activities.
A16249	FLT3-IN-1	FLT3 抑制剂	FLT3-IN-1 is a novel potent and selective Flt3 inhibitor with IC50 of 10 nM; against FLT3-ITD-expressing MV4-11 cells with IC50 of 6 nM.
A12694 SALE	Pacritinib (SB1518)	JAK2/FLT3 抑制剂	Pacritinib, also known as SB1518, is an orally bioavailable inhibitor of Janus kinase 2 (JAK2) and the JAK2 mutant JAK2V617F with potential antineoplastic activity. Pacritinib competes with JAK2 for ATP binding, which may result in inhibition of JAK2 activation, inhibition of the JAK-STAT signaling pathway, and so caspase-dependent apoptosis.
A12427	TCS 359	FLT3 抑制剂	TCS 359 is a potent inhibitor of FLT3 receptor tyrosine kinase (IC50 = 42 nM) that displays selectivity over a range of other kinases.
A10996 SALE	XL184 free base (Cabozantinib)	VEGFR 抑制剂	XL184 free base (Cabozantinib) is a small molecule designed to inhibit multiple receptor tyrosine kinases, specifically MET and VEGFR2. Product Citations (1) Fujita KI, .et al. Involvement of the Transporters P-Glycoprotein and Breast Cancer Resistance Protein in Dermal Distribution of the Multikinase Inhibitor Regorafenib and Its Active Metabolites, J Pharm Sci, 2017, Sep;106(9):2632-2641 PMID: 28479358
A10769 SALE	R406 besylate	Syk 抑制剂	R406 is an orally available spleen tyrosine kinase inhibitor with an IC50 of 41 nM.
A11411 SALE	Dovitinib (TKI-258)	RTK 抑制剂	Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively. Product Citations (1) Samuel Q. Li, etc. Targeting Wild-Type and Mutationally Activated FGFR4 in Rhabdomyosarcoma with the Inhibitor Ponatinib (AP24534). PLoS One. 2013; 8(10): e76551.
A10610	MP470 (MP-470, Amuvatinib)	RTK 抑制剂	MP470 is a c-Kit/PDGFR tyrosine kinase inhibitor.
A10887 SALE	Tandutinib (MLN518)	FLT3 抑制剂	Tandutinib (MLN518) inhibits the autophosphorylation of FLT3, c-KIT and PDGF receptor tyrosine kinases, thereby inhibiting cellular proliferation and inducing apoptosis.
A10352 SALE	ENMD-2076	Aurora A / FLT3 抑制剂	ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to VEGFR2/KDR and VEGFR3, FGFR1 and FGFR2 and PDGFRα. Phase 2.
A10508 SALE	KW-2449	FLT3/FGFR/Bcr-Abl/Aurora 抑制剂	KW-2449 is a multikinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase.
A11180	TG101209	JAK2 抑制剂	TG101209, a novel JAK2 inhibitor, has significant in vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells.
A10198 SALE	Dovitinib Dilactic acid (TKI258 Dilactic acid)	RTK 抑制剂	Dovitinib is a small-molecule multitargeted receptor tyrosine kinase inhibitor, which inhibits Ba/F3 cells transformed to IL3 independence by ZNF198-FGFR1 or BCR-FGFR1 with IC50 values of 150 nM and 90 nM, respectively.
A11753	MK-2461	c-Met 抑制剂	MK-2461, a novel multitargeted kinase inhibitor, preferentially inhibits the activated c-Met receptor.
A12419	Go 6976	PKC 抑制剂	Go6976 is a potent PKC inhibitor with IC50 of 7.9 nM, 2.3 nM, and 6.2 nM for PKC (Rat brain), PKCα, and PKCβ1, respectively. Also a potent inhibitor of JAK2 and Flt3.
A16250	FLT3-IN-2	FLT3 抑制剂	FLT3-IN-2 is potent FLT3 inhibitor.
A10770 SALE	R406 (Tamatinib)	Syk 抑制剂	R406 is a potent inhibitor of immunoglobulin E (IgE)- and IgG-mediated activation of Fc receptor signaling.

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A10027 SALE

A14156

A11962 SALE

A14214

A14411

A14025

A15003

A15520 SALE

A15548 SALE

A15904

A16246

A16248

A16249

A12694 SALE

A12427

A10996 SALE

A10769 SALE

A11411 SALE

A10610

A10887 SALE

A10352 SALE

A10508 SALE

A11180

A10198 SALE

A11753

A12419

A16250

A10770 SALE