购物车 0 ￥ 0.00
微信关注
申请试用装

FLT3

Inhibitory Selectivity

Catalog No.Inhibitor Name FLT3Other
A10996Cabozantinib
**
VEGFR2/KDR,c-Met,Kit
A10027Quizartinib
***
A11411Dovitinib
****
c-Kit,VEGFR3/FLT4,FGFR1
A10610Amuvatinib
*
c-Kit (D816H),PDGFRα (V561D)
A10887Tandutinib
*
c-Kit,PDGFRβ,CSF-1R
A11180TG101209
*
JAK2,RET,JAK3
A10508KW-2449
****
Abl (T315I),Abl,FGFR1
A10352ENMD-2076
***
RET,Aurora A,VEGFR3/FLT4
A10198Dovitinib Dilactic Acid
****
c-Kit,FGFR1,VEGFR3/FLT4
A12694Pacritinib
**
JAK2 (V617F),JAK2,TYK2
A12427TCS 359
*
A10352ENMD-2076 L-(*)-Tartaric acid
RET,Aurora A,VEGFR3/FLT4
A15904UNC2025
****
Mer
A14025AMG 925
****
CDK4,CDK1
A14214G-749
****
Mer,Aurora B,RET
A14156AZD2932
PDGFRβ,VEGFR-2,c-Kit
A10769R406
Syk
A12419Go6976
JAK2,PKCα,PKCβ1
A11962TG-02 (SB1317)
*
CDK2, JAK2
A14411Gilteritinib (ASP2215)
****
Axl
A15003AST 487
Ret, c-Kit, KDR, c-Abl
A15520Pexidartinib (PLX3397)
*
Kit, CSF-1R
A15548SU5614
A16248BPR1J-097
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

42 个项目

每页

设置升序顺序
  1. FLT3-IN-2
    Quick View

    FLT3-IN-2

    Catalog No. A16250
    Quick View
    FLT3 抑制剂
    FLT3-IN-2是有效的FLT3抑制剂。 了解更多
  2. FLT3-IN-1
    Quick View

    FLT3-IN-1

    Catalog No. A16249
    Quick View
    FLT3 抑制剂
    FLT3-IN-1是一种新型的有效选择性Flt3抑制剂，IC50为10 nM。抗表达FLT3-ITD的MV4-11细胞，IC50为6 nM。 了解更多
  3. BPR1J-097
    Quick View

    BPR1J-097

    Catalog No. A16248
    Quick View
    FLT3 抑制剂
    BPR1J-097是一种新颖的小分子FLT-3抑制剂，具有良好的体内抗肿瘤活性。 了解更多
  4. AC710 Mesylate
    Quick View

    AC710 Mesylate

    Catalog No. A16246
    Quick View
    FLT3/KIT/PDGFRα/PDGFRβ 抑制剂
    AC710 Mesylate是一种有效的选择性PDGFR家族激酶抑制剂，对于FLT3/KIT/PDGFRα/PDGFRβ的Kd值分别为0.6 nM/1.0 nM/1.3 nM/1.0 nM。 了解更多
  5. UNC-2025
    Quick View

    UNC-2025

    Catalog No. A15904
    Quick View
    Dual MER/FLT3 抑制剂
    UNC-2025是一种有效的且可生物利用的双重MER/FLT3抑制剂，IC50分别为0.74 nM和0.8 nM，选择性是Axl和Tyro3的20倍。 了解更多
  6. SU5614
    Quick View

    SU5614

    Catalog No. A15548
    Quick View
    FLT3 抑制剂
    SU5614是有效的选择性FLT3抑制剂。SU5614恢复了FL依赖性细胞中FLT3配体（FL）的抗凋亡和增殖活性。 了解更多
  7. Pexidartinib (PLX3397)
    Quick View

    Pexidartinib (PLX3397)

    Catalog No. A15520
    Quick View
    CSF1/Kit/FLT3 抑制剂
    Pexidartinib (PLX3397)是KIT，CSF1R和FLT3的小分子酪氨酸激酶（RTK）抑制剂，具有潜在的抗肿瘤活性。 了解更多
  8. AST 487
    Quick View

    AST 487

    Catalog No. A15003
    Quick View
    RET kinase 抑制剂
    AST487是Ret激酶抑制剂/FLT3抑制剂，对Ret的IC50为0.88 uM。 了解更多
  9. AMG-925
    Quick View

    AMG-925

    Catalog No. A14025
    Quick View
    Dual FLT3/CDK4 抑制剂
    AMG-925是一种有效，选择性和生物利用性的FLT3/细胞周期蛋白依赖性激酶4（CDK4）双激酶抑制剂。 了解更多
  10. Gilteritinib (ASP2215)
    Quick View

    Gilteritinib (ASP2215)

    Catalog No. A14411
    Quick View
    FLT3/Axl 抑制剂
    Gilteritinib (ASP2215)是一种有效的FLT3/AXL抑制剂，对具有AML突变或FLT3-ITD和FLT3-D835的AML具有有效的抗白血病活性。 了解更多
  11. G-749
    Quick View

    G-749

    Catalog No. A14214
    Quick View
    FLT3 抑制剂
    G-749是一种新型有效的FLT3抑制剂，对于FLT3（WT），FLT3（D835Y）的IC50为0.4 nM，0.6 nM和1 nM。 了解更多
  12. TG-02 (SB1317)
    Quick View

    TG-02 (SB1317)

    Catalog No. A11962
    Quick View
    FLT3 抑制剂
    TG-02 (SB1317)是一种新型的小分子有效CDK/JAK2/FLT3抑制剂。 了解更多
  13. AZD 2932
    Quick View

    AZD 2932

    Catalog No. A14156
    Quick View
    mutil-targeted protein tyrosine kinase 抑制剂
    AZD2932是一种有效且靶向多用途的蛋白酪氨酸激酶抑制剂，对VEGFR-2，PDGFRβ，Flt-3和c-Kit的IC50分别为8 nM，4 nM，7 nM和9 nM。 了解更多
  14. Pacritinib (SB1518)
    Quick View

    Pacritinib (SB1518)

    Catalog No. A12694
    Quick View
    JAK2/FLT3 抑制剂
    Pacritinib (SB1518)是Janus激酶2（JAK2）和JAK2突变体JAK2V617F的口服生物利用抑制剂，无细胞试验中IC50分别为23和22 nM，具有潜在的抗肿瘤活性。Pacritinib与JAK2竞争ATP结合，这可能导致抑制JAK2活化，抑制JAK-STAT信号传导途径以及半胱天冬酶依赖性凋亡。 了解更多
  15. TCS 359
    Quick View

    TCS 359

    Catalog No. A12427
    Quick View
    FLT3 抑制剂
    TCS 359是一种有效的FLT3受体酪氨酸激酶抑制剂（IC50 = 42 nM），对多种其他激酶具有选择性。 了解更多
  16. AC220 (Quizartinib)
    Quick View

    AC220 (Quizartinib)

    Catalog No. A10027
    Quick View
    FLT3 抑制剂
    AC220 (Quizartinib)是一种有效的选择性FLT3抑制剂，对于MC4-11和A375，IC50分别为0.56±0.3 nM和> 10 mM。 了解更多
  17. XL184 free base (Cabozantinib)
    Quick View

    XL184 free base (Cabozantinib)

    Catalog No. A10996
    Quick View
    VEGFR 抑制剂
    XL184 free base (Cabozantinib)是设计用来抑制多种受体酪氨酸激酶（特别是MET和VEGFR2）的小分子。 了解更多
  18. R406 besylate
    Quick View

    R406 besylate

    Catalog No. A10769
    Quick View
    Syk 抑制剂
    R406 besylate是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。 了解更多
  19. Dovitinib (TKI-258)
    Quick View

    Dovitinib (TKI-258)

    Catalog No. A11411
    Quick View
    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。 了解更多
  20. MP470 (MP-470, Amuvatinib)
    Quick View

    MP470 (MP-470, Amuvatinib)

    Catalog No. A10610
    Quick View
    RTK 抑制剂
    MP470 (MP-470,Amuvatinib)是c-Kit/PDGFR酪氨酸激酶抑制剂。 了解更多
  21. Tandutinib (MLN518)
    Quick View

    Tandutinib (MLN518)

    Catalog No. A10887
    Quick View
    FLT3 抑制剂
    Tandutinib (MLN518)是一种有效的FLT3抑制剂，c-KIT和PDGF受体酪氨酸激酶的自磷酸化，从而抑制细胞增殖并诱导细胞凋亡。 了解更多
  22. Crenolanib (CP-868596)
    Quick View

    Crenolanib (CP-868596)

    Catalog No. A11052
    Quick View
    PDGFR/FLT3 抑制剂
    Crenolanib (CP-868596)是口服生物可用的PDGFR酪氨酸激酶的选择性小分子抑制剂，在皮摩尔浓度下抑制PDGFRA和PDGFRB。 了解更多
  23. ENMD-2076
    Quick View

    ENMD-2076

    Catalog No. A10352
    Quick View
    Aurora A / FLT3 抑制剂
    ENMD-2076具有针对Aurora A和Flt3的选择性活性，IC50为14 nM和1.86 nM，对Aurora A的选择性是Aurora B的25倍，对VEGFR2/KDR和VEGFR3，FGFR1和FGFR2和PDGFRα的作用较小。阶段2。 了解更多
  24. KW-2449
    Quick View

    KW-2449

    Catalog No. A10508
    Quick View
    FLT3/FGFR/Bcr-Abl/Aurora 抑制剂
    KW-2449是FLT3、ABl、ABl-T315I和Aurora激酶的多激酶抑制剂。 了解更多
  25. TG101209
    Quick View

    TG101209

    Catalog No. A11180
    Quick View
    JAK2 抑制剂
    TG101209是一种新型的JAK2抑制剂，无细胞试验中IC50为6 nM，对Flt3和RET作用效果稍弱，IC50分别为25 nM和17 nM，作用于JAK2比作用于JAK3选择性高30倍左右，对JAK2V617F和MPLW515L/K突变型敏感。在多发性骨髓瘤中具有显着的体外活性，并且对CD45+骨髓瘤细胞显示出优先的细胞毒性。 了解更多
  26. Dovitinib Dilactic acid (TKI258 Dilactic acid)
    Quick View

    Dovitinib Dilactic acid (TKI258 Dilactic acid)

    Catalog No. A10198
    Quick View
    RTK 抑制剂
    Dovitinib是一种小分子多靶点酪氨酸激酶抑制剂，可抑制通过ZNF198-FGFR1或BCR-FGFR1转化为IL3独立性的Ba / F3细胞，IC50值分别为150 nM和90 nM。 了解更多
  27. MK-2461
    Quick View

    MK-2461

    Catalog No. A11753
    Quick View
    c-Met 抑制剂
    MK-2461是一种新型的多靶点激酶抑制剂，优先抑制活化的c-Met受体。 了解更多
  28. Go 6976
    Quick View

    Go 6976

    Catalog No. A12419
    PKC 抑制剂
    Go6976是一种有效的PKC抑制剂，对PKC（大鼠脑），PKCα和PKCβ1的IC50分别为7.9 nM，2.3 nM和6.2 nM。也是JAK2和Flt3的有效抑制剂。 了解更多
  29. HM-43239
    Quick View

    HM-43239

    Catalog No. A20826
    Quick View
    FLT3 inhibitor
    HM-43239 is a Novel Potent Small Molecule FLT3 Inhibitor, in Acute Myeloid Leukemia (AML) with FMS-like Tyrosine Kinase 3 (FLT3) Mutations 了解更多
  30. 5'-Fluoroindirubinoxime
    Quick View

    5'-Fluoroindirubinoxime

    Catalog No. A22692
    Quick View
    FLT3 inhibitor
    5'-Fluoroindirubinoxime (5??-FIO, compound 13), an Indirubin (HY-N0117) derivative, is a potent FLT3 inhibitor, with an IC50 of 15 nM. 了解更多
  31. TAK-659
    Quick View

    TAK-659

    Catalog No. A20450
    Quick View
    SYK/FLT3 inhibitor
    TAK-659 is a highly potent, selective, reversible and orally available dual inhibitor of spleen tyrosine kinase (SYK) and fms related tyrosine kinase 3 (FLT3), with an IC50 of 3.2 nM and 4.6 nM for SYK and FLT3, respectively. 了解更多
  32. FLT3-IN-3
    Quick View

    FLT3-IN-3

    Catalog No. A20172
    Quick View
    FLT3 inhibitor
    FLT3-IN-3 is a potent FLT3 inhibitor with IC50s of 13 and 8 nM for FLT3 WT and FLT3 D835Y, respectively. 了解更多
  33. CCT241736
    Quick View

    CCT241736

    Catalog No. A21097
    Quick View
    dual FLT3/Aurora kinase inhibitor
    CCT241736 is a potent and orally bioavailable dual FLT3 and Aurora kinase inhibitor. 了解更多
  34. Gilteritinib hemifumarate
    Quick View

    Gilteritinib hemifumarate

    Catalog No. A18235
    Quick View
    FLT3/AXL inhibitor
    Gilteritinib hemifumarate is a potent FLT3/AXL inhibitor with IC50 of 0.29 nM/0.73 nM, respectively. 了解更多
  35. FN-1501
    Quick View

    FN-1501

    Catalog No. A13559
    Quick View
    FLT3/CDK inhibitor
    FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity. 了解更多
  36. FLT3-IN-4
    Quick View

    FLT3-IN-4

    Catalog No. A18509
    Quick View
    FLT3 inhibitor
    FLT3-IN-4 is a potent and orally effective Fms-like tyrosine receptor kinase 3 (FLT3; IC50=7 nM) inhibitor for treating acute myelogenous leukemia. 了解更多
  37. PROTAC FLT-3 degrader 1
    Quick View

    PROTAC FLT-3 degrader 1

    Catalog No. A18682
    Quick View
    FLT-3 ITD degrader
    PROTAC FLT-3 degrader 1 is an FLT-3 internal tandem duplication (ITD) degrader with an IC50 0.6 nM. Anti-proliferative activity; apoptosis induction. 了解更多
  38. BSc5371
    Quick View

    BSc5371

    Catalog No. A19465
    Quick View
    FLT3 inhibitor
    BSc5371 is a potent and irreversible FLT3 inhibitor, with Kds of 1.3, 0.83, 1.5, 5.8 and 2.3 nM for mutant FLT3(D835H), FLT3(ITD, D835V), FLT3(ITD, F691L), FLT3-ITD and wild type FLT3wt, respectively. 了解更多
  39. MRX-2843
    Quick View

    MRX-2843

    Catalog No. A16958
    Quick View
    MERTK and FLT3 抑制剂
    MRX-2843是MERTK和FLT3的口服小分子抑制剂。 了解更多
  40. SB1317 (TG02)
    Quick View

    SB1317 (TG02)

    Catalog No. A13454
    Quick View
    CDK/JAK2/FLT3 抑制剂
    SB1317是细胞周期蛋白依赖性激酶（CDKs）、类FMS酪氨酸激酶-3（FLT3）和Janus激酶2（JAK2）的有效抑制剂，CDK2、JAK2和FLT3的IC50值分别为13nM、56nM和73nM。 了解更多
  41. R406 (Tamatinib)
    Quick View

    R406 (Tamatinib)

    Catalog No. A10770
    Quick View
    Syk 抑制剂
    R406 (Tamatinib)是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。 了解更多
  42. TG-101348 (Fedratinib, SAR302503)
    Quick View

    TG-101348 (Fedratinib, SAR302503)

    Catalog No. A11082
    Quick View
    JAK2/FLT3 抑制剂
    TG-101348 (Fedratinib,SAR302503)是Janus相关激酶2的口服生物利用型，ATP竞争性和选择性抑制剂，在无细胞试验中IC50为3 nM，作用于JAK2比作用于JAK1和JAK3选择性高35和334倍,具有潜在的抗肿瘤活性。 了解更多

42 个项目

每页

设置升序顺序
FILTER BY:

购物选项

作用机制
  1. Inhibitor (抑制剂) (41)
  2. Degrader (降解剂) (1)
靶点
  1. Abl (1)
  2. Aurora A (2)
  3. Axl (1)
  4. CDK (2)
  5. CDK4 (1)
  6. CSF1R (4)
  7. FGFR1 (3)
  8. FGFR3 (2)
  9. FLT3 (25)
  10. JAK2 (7)
  11. Kit (5)
  12. Mer (1)
  13. PDGFRα (2)
  14. PDGFRβ (5)
  15. PKCα (1)
  16. PKCβ (1)
  17. RET (2)
  18. Src (1)
  19. Syk (1)
  20. VEGFR1 (FLT1) (2)
  21. VEGFR2 (FLK1) (2)
  22. VEGFR3 (FLT4) (2)
联系我们
ChinaChina

Adooq 中国 (南京百鑫德诺生物科技有限公司)

免费电话: 400-025-6535

企业QQ: 400-025-6535

www.adooq.cn

sales@adooq.cn

United StatesUnited States

Adooq Bioscience

Toll Free: (866) 930-6790

Fax: +1-323-606-8156

Email: sales@adooq.com

Not your Region? View all Distributors

溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

ADOOQ 产品质量保证
Guaranteed product quality, 365 days Unconditional Return & Replacement

We promise all products to perform as described.

立即申请
Get Code
联系我们
查看FAQs

Adooq 公司

产品订购

技术资源

地址

© 2006-2019 AdooQ BioScience （南京百鑫德诺生物科技有限公司）. All Rights Reserved.
苏ICP备14027875号
Accept Payment
Rewards