Raf

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Raf	C-Raf/Raf-1	B-Raf	Other
A10739	Vemurafenib		*	**	SRMS,ACK1,MAP4K5 (KHS1)
A10002	PLX-4720		***	***	BRK,FRK,CSK
A11381	Dabrafenib		****	****
A10420	GDC-0879			****
A10773	RAF265			**	VEGFR2
A11063	AZ 628		**	**
A10661	NVP-BHG712		*		EphB4,c-Src,c-Abl
A10829	SB590885			****
A11077	ZM 336372		*
A10001	Sorafenib		****	**	mVEGFR2(Flk1),mVEGFR3,mPDGFRβ
A11436	GW5074		***
A13323	TAK-632		****	***	Aurora B,PDGFRβ,FGFR3
A13772	CEP-32496		**	***	RET,PDGFRβ,LCK
A13226	Encorafenib			****
A14019	RO5126766		*	***	MEK1
A15855	PLX7904
A11240	MLN2480
A10250	Regorafenib (BAY 73-4506)		****	**	FGFR1, Kit, PDGFRβ, RET, Tie-2 , VEGFR1, VEGFR2, VEGFR3
A11211	ML 786 dihydrochloride		****	****	Abl-1, DDR2, EPHA2, RET, PERK
A12739	PF-04880594		****	****
A13525	L-779450	****			p38α, GSK3β, Lck

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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PLX7904

Catalog No. A15855
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Raf 抑制剂

PLX7904是有效的选择性悖论突破性RAF抑制剂。它能够有效抑制突变型BRAF黑色素瘤细胞中ERK1/2的激活，但不能过度激活突变型RAS表达细胞中的ERK1/2。了解更多

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MLN2480 (BIIB-024)

Catalog No. A11240
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pan-Raf 抑制剂

MLN2480 (BIIB-024)是一种口服的Raf激酶抑制剂。了解更多

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L-779450

Catalog No. A13525
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Raf 抑制剂

L-779450是有效的选择性 B-Raf 抑制剂，Kd 为 2.4 nM。是神经外伤性疾病的潜在治疗方法。了解更多

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