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MAPK | MAPK 信号通路



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Catalog No. Product Name Application Product Information
A10453 SALE

Honokiol

Antiangiogenic and Antitumor Agent
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
A14137 SALE

SL-327

MKK/MEK 抑制剂
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
A11264

Refametinib

MEK 抑制剂
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
A15050

Cobimetinib (racemate)

MEK 抑制剂
Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
A15051

Cobimetinib (R-enantiomer)

MEK 抑制剂
Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
A15157

MEK inhibitor

MEK 抑制剂
MEK inhibitor is a potent MEK inhibitor, antitumor agent.
A15762

BI-847325

MEK/Aurora 抑制剂
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A14380

G-479

MEK 抑制剂
G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
A12974

GDC-0623

MEK1 抑制剂
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
A16032

PD 198306

MEK 抑制剂
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
A16044

PD 334581

MEK1 抑制剂
PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1.
A10256 SALE

PD0325901

MEK 抑制剂
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
A10257

AZD6244 (Selumetinib)

MEK 抑制剂
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
A10705

PD98059

MEK 抑制剂
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
A10212 SALE

PD184352 (CI-1040)

MEK1/2 抑制剂
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
A10957 SALE

U0126-EtOH

MEK 抑制剂
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
A10089 SALE

AS703026 (Pimasertib)

MEK1/2 抑制剂
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
A11029 SALE

GSK1120212 (JTP-74057, Trametinib)

MEK 抑制剂
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
A10151 SALE

BIX 02189

MEK 抑制剂
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
A11040 SALE

TAK-733

MEK 抑制剂
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
A10115

AZD8330

MEK 抑制剂
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
A10704

PD318088

MEK 抑制剂
PD318088 is an inhibitor of MEK1 AND MEK2.
A10150

BIX02188

MEK5 抑制剂
BIX02188 is a potent and selective inhibitor of MEK5.
A11441 SALE

GDC-0973 (Cobimetinib)

MEK1 抑制剂
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
A11493 SALE

MEK162 (ARRY-438162, Binimetinib)

MEK1/2 抑制剂
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
A11247

RO4927350

MEK1/2 抑制剂
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
A12866

Refametinib (RDEA-119, BAY 86-9766)

MEK1/2 抑制剂
Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity.
A13119

Balamapimod (MKI-833)

Ras/Raf/MEK 抑制剂
Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor.
A14019

RO5126766 (CH5126766)

Raf/MEK dual 抑制剂
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
A13750

Hypothemycin

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Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone.
A13272

RO4987655

MEK1 抑制剂
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity.
A11225

Pluripotin (SC-1)

ERK1/RasGAP 抑制剂
The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
A11794 SALE

Ulixertinib (BVD-523, VRT752271)

ERK1/ERK2 抑制剂
VRT752271 is a pyrrole inhibitors of ERK protein kinase.
A12824 SALE

SCH772984

ERK 抑制剂
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
A12505 SALE

TCS ERK 11e (VX-11e)

ERK2 抑制剂
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
A13420 SALE

GDC0994

ERK1/2 抑制剂
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
A14090

XMD 17-109

ERK5 抑制剂
XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells.
A14119 SALE

FR 180204

ERK 抑制剂
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
A11609 SALE

XMD8-92

BMK1/ERK5 抑制剂
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .
A13977

TMCB

CK2/ERK8 抑制剂
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
A15802 SALE

DEL-22379

ERK 抑制剂
DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes.
A16231

APS-2-79

KSR/Ras 抑制剂
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
A16232

ERK5-IN-1

ERK5 抑制剂
ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM.
A16233

Tomatidine

ERK/Akt/NF-kB 抑制剂
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
A13678

SB-242235

p38 MAPK 抑制剂
SB-242235 is a potent and selective p38 MAP kinase inhibitor that may be an effective therapy for cytokine-mediated diseases such as autoimmune or inflammatory diseases.
A13552

RWJ-67657

p38 MAPK 抑制剂
RWJ-67657 is a potent p38 MAPK inhibitor.
A13563

BMS-582949

p38 MAPK 抑制剂
BMS-582949 Is a Dual Action p38 Kinase Inhibitor Well Suited To Avoid Resistance Mechanisms That Increase p38 Activation in Cells.
A10895

Pexmetinib (ARRY-614)

p38 MAPK 抑制剂
Pexmetinib is a potent inhibitor of cytokine synthesis, via the dual inhibition of p38 mitogen-activated protein kinase (MAPK), and Tie2/Tek receptor tyrosine kinase.
A10970

AMG 548

p38 MAPK 抑制剂
AMG 548 is a potent and selective inhibitor of p38α. It displays >1000-fold selectivity against 36 other kinases, and it inhibits whole blood LPS-stimulated TNFα.
A11101

SKF 86002 Dihydrochloride

p38 MAPK 抑制剂
SKF 86002 Dihydrochloride is inhibitor of p38 MAP kinase (IC50 = 0.1 - 1 uM). Potently inhibits LPS-induced IL-1 and TNF-α production in human monocytes (IC50 = 1 uM).

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