MAPK

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Catalog No. Product Name Application Product Information
A10453 SALE

Honokiol

Antiangiogenic and Antitumor Agent
Honokiol is a lignan present in the cones, bark, and leaves of Magnolia grandiflora that has shown pro-apoptotic effects in melanoma, sarcoma, myeloma, leukemia, bladder, lung, prostate, oral squamous cell carcinoma and colon cancer cell lines.
A16044

PD 334581

MEK1 抑制剂
PD 334581 is used in biological studies to evaluate halogen bonding as a novel interaction for rational drug design. It is also an inhibitor of MEK1.
A16032

PD 198306

MEK 抑制剂
PD 198306 is a potent, selective and non-ATP competitive MAPK/ERK-kinase (MEK) inhibitor.
A12974

GDC-0623

MEK1 抑制剂
GDC-0623 is a potent and ATP-uncompetitive MEK1 inhibitor with Ki of 0.13 nM. Phase 1.
A14380

G-479

MEK 抑制剂
G-479 is an potent MEK inhibitor. G-479 with polarity distributed throughout the molecule was shown improved bioactivity over GDC-0623 in many aspects.
A15762

BI-847325

MEK/Aurora 抑制剂
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
A15157

MEK inhibitor

MEK 抑制剂
MEK inhibitor is a potent MEK inhibitor, antitumor agent.
A15051

Cobimetinib (R-enantiomer)

MEK 抑制剂
Cobimetinib R-enantiomer is the R-enantiomer of Cobimetinib, which is a potent, highly selective inhibitor of mitogen-activated protein kinase kinase(MEK1/2).
A15050

Cobimetinib (racemate)

MEK 抑制剂
Cobimetinib is a potent, highly selective inhibitor of MEK1/2.
A11264

Refametinib

MEK 抑制剂
Refametinib is a potent, ATP non-competitive and highly selective inhibitor of MEK1 and MEK2 with IC50 of 19 nM and 47 nM, respectively.
A14137 SALE

SL-327

MKK/MEK 抑制剂
SL-327 is a selective inhibitor of MEK1 and MEK2 (IC50 values are 0.18 and 0.22 μM respectively); blocks hippocampal LTP in vitro. Brain penetrant in vivo, blocking fear conditioning and learning in rats, and producing neuroprotection in mice, following systemic administration.
A10150

BIX02188

MEK5 抑制剂
BIX02188 is a potent and selective inhibitor of MEK5.
A11441 SALE

GDC-0973 (Cobimetinib)

MEK1 抑制剂
Cobimetinib (GDC-0973, RG7420) is a potent and highly selective MEK1 inhibitor with IC50 of 4.2 nM, showing more than 100-fold selectively for MEK1 over MEK2 and showed no significant inhibition when tested against a panel of more than 100 of serine-threonine and tyrosine kinases.
A11493 SALE

MEK162 (ARRY-438162, Binimetinib)

MEK1/2 抑制剂
MEK162 (ARRY-438162) is a potent, selective, ATP uncompetitive inhibitor of MEK1/2.
A11247

RO4927350

MEK1/2 抑制剂
RO4927350 a potent and highly selective non-ATP-competitive MEK1/2 inhibitor.
A12866

Refametinib (RDEA-119, BAY 86-9766)

MEK1/2 抑制剂
Refametinib, also known as RDEA119, BAY 86-9766, is an orally bioavailable selective MEK inhibitor with potential antineoplastic activity.
A13119

Balamapimod (MKI-833)

Ras/Raf/MEK 抑制剂
Balamapimod, also known as MKI-822, is a Ras/Raf/MEK inhibitor.
A14019

RO5126766 (CH5126766)

Raf/MEK dual 抑制剂
RO5126766, also known as CH5126766, is a protein kinase inhibitor specific for the Raf and MEK mitogen-activated protein kinases (MAPKs) with potential anti-neoplastic activity.
A13750

Hypothemycin

-
Hypothemycin is a resorcylic acid lactone polyketide. It was found to inhibit the proliferation of mouse and human T cells stimulated with anti-CD3 mAb + PMA and of human PBMC stimulated with anti-CD3 mAb alone.
A13272

RO4987655

MEK1 抑制剂
RO4987655 is an orally active small molecule, targeting mitogen-activated protein kinase kinase 1 (MAP2K1 or MEK1), with potential antineoplastic activity.
A10704

PD318088

MEK 抑制剂
PD318088 is an inhibitor of MEK1 AND MEK2.
A10115

AZD8330

MEK 抑制剂
AZD8330 is a novel, selective, non-ATP competitive MEK 1/2 inhibitor with IC50 of 7 nM. Phase 1.
A10256 SALE

PD0325901

MEK 抑制剂
PD0325901 is MEK inhibitor and non-competitive with ATP, Kiapp of 1 nM against activated MEK1 and MEK2.
A10257

AZD6244 (Selumetinib)

MEK 抑制剂
AZD6244 (Selumetinib) also known as Selumetinib, ARRY142886, AZD-6244 & ARRY-142886 is MEK 1/2 inhibitor with GI50 values ranging from 14 to 50 nm.
A10705

PD98059

MEK 抑制剂
PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase.
A10212 SALE

PD184352 (CI-1040)

MEK1/2 抑制剂
PD184352 (CI-1040) is an ATP non-competitive MEK1/2 inhibitor with IC50 of 17 nM in cell-based assays, 100-fold more selective for MEK1/2 than MEK5. Phase 2.
A10957 SALE

U0126-EtOH

MEK 抑制剂
U0126-EtOH is an inhibitor of both MEK1 and MEK2 with an IC50 of 72 nM and 58 nM respectively.
A10089 SALE

AS703026 (Pimasertib)

MEK1/2 抑制剂
AS703026 is a novel, selective, orally bioavailable MEK1/2 inhibitor that inhibits growth and survival of MM cells and cytokine-induced osteoclast differentiation.
A11029 SALE

GSK1120212 (JTP-74057, Trametinib)

MEK 抑制剂
GSK1120212 (JTP-74057) strongly prevented the activities of MEK1 and MEK2 kinases rather than activities of other 98 kinases.
A10151 SALE

BIX 02189

MEK 抑制剂
BIX 02189 is a selective dual MEK5 and ERK5 (or BMK1) kinase inhibitor, with IC50 values of 1.5, 59, 580 and >6200 nM for MEK5, ERK5, TGFbR1 and other closely related kinases respectively.
A11040 SALE

TAK-733

MEK 抑制剂
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity.
A13977

TMCB

CK2/ERK8 抑制剂
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
A15802 SALE

DEL-22379

ERK 抑制剂
DEL-22379 is a potent and selective ERK Dimerization inhibitor that inhibits ERK Dimerization without affecting ERK phosphorylation, forestalls tumorigenesis driven by RAS-ERK pathway oncogenes.
A16231

APS-2-79

KSR/Ras 抑制剂
APS-2-79 is an antagonist of MEK phosphorylation by RAF through direct binding of the KSR active site.
A16232

ERK5-IN-1

ERK5 抑制剂
ERK5-IN-1 exhibits potent inhibition of ERK5 with cellular EC50 values of 0.19 uM and enzymatic IC50 values of 0.087 uM and of LRRK2[G2019S] with enzymatic IC50 values of 0.026uM.
A16233

Tomatidine

ERK/Akt/NF-kB 抑制剂
Tomatidine inhibits the phosphorylation of ERK, Akt, and the nuclear content of NF-kB. possess anti-inflammatory properties.
A11609 SALE

XMD8-92

BMK1/ERK5 抑制剂
XMD8-92 is a potent and selective BMK1/ERK5 inhibitor .
A14119 SALE

FR 180204

ERK 抑制剂
FR 180204 is a novel and selective inhibitor of extracellular signal-regulated kinase (ERK), which may be a potential new therapy for rheumatoid arthritis.
A14090

XMD 17-109

ERK5 抑制剂
XMD17-109 is a novel, specific inhibitor of ERK-5 with an EC50 value of 4.2 uM in HEK293 cells.
A13420 SALE

GDC0994

ERK1/2 抑制剂
GDC-0994 is a potent and selective Erk1/2 inhibitor. GDC-0994 inhibits both ERK phosphorylation and activation of ERK-mediated signal transduction pathways.
A12505 SALE

TCS ERK 11e (VX-11e)

ERK2 抑制剂
TCS ERK 11e (VX-11e) is a potent and selective extracellular signal-related kinase 2 (ERK2) inhibitor (Ki values are <2, 395, 540 and 852 nM for ERK2, GSK-3, Aurora Kinase A and Cdk2 respectively). Potently blocks proliferation of HT29 cells (IC50 = 48 nM).
A12824 SALE

SCH772984

ERK 抑制剂
SCH772984 is a novel, specific inhibitor of ERK1/2 with IC50 of 4 nM and 1 nM, respectively.
A11794 SALE

Ulixertinib (BVD-523, VRT752271)

ERK1/ERK2 抑制剂
VRT752271 is a pyrrole inhibitors of ERK protein kinase.
A11225

Pluripotin (SC-1)

ERK1/RasGAP 抑制剂
The activity of Pluripotin (SC-1) is mediated by the combined inhibition of RasGAP and ERK1 with Kd values of 98 and 212 nM, respectively.
A16035

SX 011

P38 MAPK 抑制剂
SX 011 is a selective p38α, p38β and JNK-2 inhibitor. Reported to display no significant activity at p38γ, p38δ, ERK-2 and JNK-1.
A16037

EO 1428

P38 MAPK 抑制剂
EO 1428 is a synthetic 4-aminobenzophenone small molecule identified in an optimization study for inhibitors of p38 MAP kinase.
A16038

JX 401

P38 MAPK 抑制剂
JX 401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM).
A16055

SB 706504

p38 MAPK 抑制剂
SB 706504 is a p38 MAPK inhibitor, preventing LPS-induced transcription of a range of chemokineis and cytokines in chronic obstructive pulmonary disease monocyte derived macrophages.
A16058

DBM 1285 dihydrochloride

p38 MAPK 抑制剂
DBM 1285 dihydrochloride is a p38 MAPK inhibitor. Supresses p38 phosphorylation and LPS-induced TNF-α production in macrophages and in vivo.
A16015

AL 8697

p38 MAPK 抑制剂
AL-8697 is a selective p38 MAPK(mitogen-activated protein Kinase) inhibitor, which is also named P38α inhibitor. It has the function of inhibiting the activity of P38 MAPK.

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