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Stem Cells / Wnt 信号通路

产品 1 到 50 共 109个

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Catalog No. Product Name Application Product Information
A10258 SALE

GDC-0449 (Vismodegib)

Hedgehog 拮抗剂
GDC-0449 (Vismodegib) is a more potent novel and specific synthetic oral hedgehog pathway inhibitor with an IC50 of 3 nM.
A16349

HPI-4

hedgehog 抑制剂
HPI-4 is a hedgehog (Hh) signaling pathway inhibitor with median inhibitory concentration (IC50) less than 10 μM.
A16229

RU-SKI 43

Hhat 抑制剂
RU-SKI 43 is a small molecule inhibitor of Hhat(Hedgehog acyltransferase), the enzyme responsible for the attachment of palmitate onto Shh.
A16111

MK-4101

Hedgehog 抑制剂
MK-4101 is a potent and selective inhibitor of the Hedgehog Pathway.
A12418

HhAntag

-
HhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway.
A12920

Hh-Ag1.5

Hedgehog 抑制剂
Hh-Ag1.5 is one of the most potent and selective small-molecule agonists of the Hedgehog pathway, targeting Smoothened (Smo) with an EC50 ~1 nM.
A11442

GANT 58

GLI 拮抗剂
A13252 SALE

GANT61

GLI 拮抗剂
GANT61 is an inhibitor for GLI1 as well as GLI2-induced transcription, inhibits hedgehog with IC50 of 5 μM, displays selectivity over other pathways, such as TNF and glucocorticoid receptor gene transactivation.
A13095 SALE

SANT-1

Sonic hedgehog 抑制剂
SANT-1 is a potent, cell-permeable inhibitor of Sonic hedgehog (Shh) signaling; high affinity antagonist of smoothened activity (KD = 1.2 nM). Inhibits smoothened agonist effects with an IC50 of 20 nM (in Shh-LIGHT2 cells).
A11351

TAK-441

Hedgehog 抑制剂
TAK-441 is a pyrrolo[3,2-c]pyridine derivative, as a highly potent and orally active hedgehog signaling inhibitor.
A11048 SALE

LY2940680 (Taladegib)

SMO 拮抗剂
LY2940680 has been shown to affect a cancer cell signaling pathway initiated by the Hedgehog (Hh) protein.
A10249

Cyclopamine

Hedgehog signaling 抑制剂
Cyclopamine is a Smo or hedgehog signaling pathway inhibitor.
A16219

JW74

Wnt 抑制剂
JW74 is an efficient and specific inhibitor of the canonical Wnt signaling. JW74 shows a reduction of canonical Wnt signaling in the ST-Luc assay with IC50 values of 790 nM.
A16217

Hexachlorophene

Wnt/beta-catenin 抑制剂
Hexachlorophene is a potent KCNQ1/KCNE1 potassium channel activator with EC50 of 4.61 ± 1.29 uM; also is an inhibitor of Wnt/beta-catenin signaling.
A16216

CCT251545

Wnt 抑制剂
CCT251545 is an orally bioavailable and potent inhibitor of WNT signaling with IC50 value of 5 nM.
A16094

WAY-262611

Wnt pathway activator
WAY-262611 is a wingless β-Catenin agonist that increases bone formation rate; with EC50 of 0.63 uM in TCF-Luciferase assay.
A16064 SALE

IQ-1

Wnt/beta-catenin 抑制剂
IQ-1 is a cell-permeable tetrahydroisoquinolinylidene compound that modulates Wnt/beta-catenin signaling.
A15840

ETC-159

Wnt 抑制剂
ETC-159 is a potent and specific inhibitor of Wnt secretion. ETC-159 inhibits beta-catenin reporter activity in a dose-dependent manner with an IC50 of 2.9 nM.
A15851 SALE

BML-284 (Wnt agonist 1)

Wnt 激动剂 1
Wnt agonist 1 is a cell-permeable Wnt signaling activator. It nduces beta-catenin and TCF-dependent transcriptional activity with EC50 value of 0.7 uM.
A13192

IWP-3

Wnt 抑制剂
IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
A13978 SALE

IWP-L6

PORCN 抑制剂
IWP-L6 is a potent inhibitor of Porcupine (Porcn), a membrane-bound O-acyltransferase (MBOAT) (EC50 = 0.5 nM).
A15229 SALE

Salinomycin sodium salt

-
Salinomycin is an antibacterial and coccidiostat ionophore therapeutic drug.
A15856

PRI-724

CBP/beta-catenin 拮抗剂

PRI-724, an isomer or enantiomer of ICG-001 (A11039), is a potent, specific inhibitor of the canonical Wnt signaling pathway in cancer stem cells with potential antineoplastic activity.

A16198

Cardiogenol C HCl

-
Cardiogenol C is a diaminopyrimidine compound that induces the differentiation of MHC- (myosin heavy chain) positive cardiomyocytes from embryonic stem cells with an EC50 value of 0.1 uM. Cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells.
A16353

KYA1797K

Wnt/beta-catenin 抑制剂
KYA1797K is a highly potent and selective Wnt/beta-catenin inhibitor with IC50 of 0.75 μM (TOPflash assay).
A12951 SALE

Wnt-C59

PORCN/Wnt 抑制剂
Wnt-C59 is a very potent and highly selective Wnt signaling antagonist with an IC50 ~ 74 pM in the Wnt signaling reporter assay.
A12707 SALE

IWP-2

Wnt 抑制剂
IWP-2 is an inactivator of Porcn function and inhibitor of Wnt production, and blocks beta-catenin accumulation. Wnt/b-catenin ('canonical') pathway maintains transcriptional programs that enable stem cells to remain multipotent.
A12737 SALE

IWR-1-endo

Wnt 抑制剂
IWR-1-endo is a potent inhibitor of the Wnt response, blocking a cell-based Wnt/β-catenin pathway reporter response with an IC50 value of 180 nM. Wnt proteins bind to receptors on the cell surface, initiating a signaling cascade that leads to β-catenin activation of gene transcription.
A12816 SALE

LGK-974

PORCN 抑制剂
LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.
A12362 SALE

KY02111

Wnt 抑制剂
KY02111 is a potent and selective Wnt signaling pathway inhibitor discovered by a cell-based screening, which promotes differentiation of hESCs/iPSCs to cardiomyocytes when used at the second stage of differenitation.
A10994 SALE

XAV 939

PARP 抑制剂
XAV 939 is a TNKS inhibitor (IC50 values are 0.011 and 0.004 μM for TNKS1 and TNKS2 respectively).
A11039 SALE

ICG-001

Wnt/beta-catenin 抑制剂
ICG-001 is a specific inhibitor of Wnt/β-catenin signaling pathway that inhibits β-catenin/cyclic AMP response element-binding (CREB) protein transcription (IC50=3 microM) .
A16218 SALE

iCRT 14

CRT 抑制剂
iCRT 14 is a novel potent inhibitor of beta-catenin-responsive transcription (CRT) (IC50 = 40.3 nM in assays of Wnt pathway activity).
A15773

Cardiogenol C hydrochloride

-
Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
A13986

WAY-316606

sFRP-1 抑制剂
WAY-316606 is a small molecule inhibitors of the secreted protein sFRP-1, an endogenous antagonist of the secreted glycoprotein Wnt.
A13795

FH535

??-Catenin/Tcf 抑制剂
A16236

TA-01

CK 抑制剂
TA-01 potently inhibits CK1ε, CK1δ,and p38α (IC50values are 6.4, 6.8, and 6.7 nM respectively).
A16235

SR-3029

CK1??/CK1?? 抑制剂
SR-3029 is a potent and highly specific CK1δ/CK1ε inhibitor with the IC50 of 97 nM.
A16234

CX-4945 sodium salt

CK2 抑制剂
CX-4945 sodium salt is a potent and selective ATP-competitive small molecule protein kinase CK2 inhibitor with a Ki and an IC50 of 0.38 and 1 nM for recombinant human CK2α, respectively.
A15764 SALE

IC 261

CK1?? and CK1?? 抑制剂
IC 261 is CK1δ and CK1ε inhibitor.
A15257

TBB

CK2 抑制剂
TBB is a highly selective, ATP/GTP-competitive inhibitor of casein kinase-2 (CK2)with IC50s of 0.9 and 1.6 uM for rat liver and human recombinant CK2 respectively).
A15069 SALE

DMAT

CK2 抑制剂
DMAT is a potent and specific CK2 inhibitor with an IC50 of 0.13 uM.
A14101

TTP-22

CK2 抑制剂
TTP 22 is a high affinity, casein kinase 2 (CK2) inhibitor (IC50= 0.1uM, Ki= 40nM). In addition, TTP 22 shows selectivity for CK2 over JNK3, ROCK1, and MET (inhibitory effects displayed at greater than 10 uM). TTP 22 is highly conserved serine/threonine protein kinase that is also involved in cell proliferation, cell differentiation and apoptosis.
A13949 SALE

D4476

CK1 抑制剂
D4476 is a cell-permeant inhibitor of casein kinase 1.
A13574

LH 846

CK1 抑制剂
LH 846 is a selective inhibitor of casein kinase (CK) 1δ (IC50 values are 290 nM, 1.3 μM and 2.5 μM for CK1δ, ε and α)
A11060 SALE

CX-4945 (Silmitasertib)

CK2 抑制剂
CX-4945 is a potent and selective orally bioavailable small molecule inhibitor of CK2 that inhibits human umbilical vein endothelial cell migration, tube formation, and blocks CK2-dependent hypoxia-induced factor 1 alpha (HIF-1α) transcription in cancer cells.
A13977

TMCB

CK2/ERK8 抑制剂
MCB has been shown to inhibit both casein kinase 2 (CK2) and extracellular-signal-regulated kinase 8 (ERK8/MAPK15) (IC50 = 0.50 uM for both CK2 and ERK8).
A13584

A-3 Hydrochloride

PKA, PKG, Casein Kinase I and II 抑制剂
A-3 Hydrochloride is an inhibitor of PKA (cAMP-dependent protein kinase, Ki=4.3μM) and cGMP-dependent protein kinase, Ki=3.8μM, PKC (protein kinase C, Ki=47μM), casein kinase I and II, and MLCK (myosin light chain kinase) ( Ki=7.4μM).
A10344 SALE

Ellagic acid

-
Ellagic acid is a natural phenol antioxidant found in numerous fruits and vegetables. The antiproliferative and antioxidant properties of ellagic acid have spurred preliminary research into the potential health benefits of ellagic acid consumption.
A11781

PF 670462

Casein kinase 抑制剂
Potent and selective casein kinase 1ε (CK1ε) and CK1δ inhibitor (IC50 values are 7.7 and 14 nM respectively) that displays > 30-fold selectivity over 42 other common kinases. Inhibits PER protein nuclear translocation (EC50 = 290 nM) causing phase shifts in circadian rhythms and attenuates methamphetamine-stimulated locomotion in vivo.

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