Angiogenesis

Angiogenesis is the formation and remodelling of new blood vessels and capillaries from growth of pre-existing blood vessels. It normally occurs during wound healing and embryonic development, but is also required for tumour growth and metastasis in cancer.

产品 51 到 100 共 428个

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  1. Mubritinib (TAK 165)

    Catalog No. A10612
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    HER2/ErbB2 抑制剂
    Mubritinib (TAK 165)是一种有效的EGFR和p34cdc2抑制剂,IC50分别为6 nM和0.2 ?M。Mubritinib(TAK 165)也抑制p33cdk2和p33cdk5。 了解更多
  2. TAK-285

    Catalog No. A11236
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    HER2/EGFR 抑制剂
    TAK-285是一种研究性的HER2/EGFR抑制剂,可在具有完整血脑屏障 (BBB) 的大鼠中穿透CNS。TAK-285对HER2和EGFR激酶具有抑制活性,HER2和EGFR的IC50值分别为17 nmol/L (95%CI 12-24)和23 nmol/L (95%CI 18-30)。 了解更多
  3. AST-6

    Catalog No. A10062
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    EGFR 抑制剂
    AST-6是表皮生长因子受体1和2的新型不可逆抑制剂,可在体内外抑制肿瘤生长。 了解更多
  4. Tyrphostin AG 879

    Catalog No. A10053
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    HER2 抑制剂
    Tyrphostin AG 879是神经生长因子(NGF)TrkA酪氨酸激酶活性的抑制剂。 了解更多
  5. BIBX 1382

    Catalog No. A11334
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    EGFR 抑制剂
    BIBX 1382是一种细胞可渗透的嘧啶嘧啶化合物,可作为一种有效的,可逆的,ATP竞争性高选择性的EGFR抑制剂。 了解更多
  6. AG-17

    Catalog No. A11949
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    EGFR 抑制剂
    AG-17是人表皮样癌细胞系A431中EGFR激酶的抑制剂,IC50值为460 μM,作用于PDGFR更有效,IC50值为0.5μM。 了解更多
  7. Butein

    Catalog No. A12448
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    Butein是一种植物多酚,用作特定的蛋白酪氨酸激酶抑制剂。 了解更多
  8. CGP-52411

    Catalog No. A12867
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    EGFR 抑制剂
    CGP-52411是表皮生长因子受体(EGFR)的选择性抑制剂(体外IC50 = 0.3μM)。还抑制和逆转与阿尔茨海默氏病有关的Aβ42纤维的形成。 了解更多
  9. ARRY-543 (Varlitinib, ASLAN001)

    Catalog No. A12868
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    ErbB 抑制剂
    ARRY-543 (Varlitinib,ASLAN001)是一种新型口服ErbB家族抑制剂,与批准的ErbB抑制剂不同,它直接或间接靶向ErbB家族的所有成员,包括ErbB3,在治疗通过多个ErbB家族成员发出信号的肿瘤方面具有潜在优势。 了解更多
  10. CO-1686 (Rociletinib, AVL-301)

    Catalog No. A13028
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    EGFR 抑制剂
    CO-1686是一种新型的口服靶向共价(不可逆)抑制剂,可抑制表皮生长因子受体(EGFR)的致癌突变形式,目前正在研究用于治疗非小细胞肺癌(NSCLC)。 了解更多
  11. (-)-Gallocatechin

    Catalog No. A12003
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    (-)-Gallocatechin具有清除自由基的能力。它抑制牙龈卟啉单胞菌在颊上皮细胞上的生长和粘附。 了解更多
  12. WHI-P 154

    Catalog No. A14049
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    JAK3 抑制剂
    WHI-P 154是一种JAK3抑制剂,IC50 = 1.8uM。WHI-P 154还在体外抑制巨噬细胞中的STAT1激活,iNOS表达和NO生成。 了解更多
  13. Poziotinib

    Catalog No. A13044
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    EGFR 抑制剂
    Poziotinib是一种口服生物利用的,基于喹唑啉的泛表皮生长因子受体(EGFR或HER)抑制剂,具有潜在的抗肿瘤活性。 了解更多
  14. EGFR Inhibitor

    Catalog No. A13673
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    EGFR 抑制剂
    EGFR inhibitor是一种可透过细胞的4,6-二取代嘧啶化合物,可选择性抑制EGFR激酶,在体外的IC50值为21 nM,可阻断细胞中的受体自身磷酸化。 了解更多
  15. Epidermal Growth Factor Receptor Peptide (985-996)

    Catalog No. A14877
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    Epidermal Growth Factor Receptor Peptide (985-996)存在于细胞表面,并通过其特定配体(包括表皮生长因子和转化生长因子)的结合而被激活。 了解更多
  16. Compound 56

    Catalog No. A14953
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    EGFR 抑制剂
    Compound 56是EGFR酪氨酸激酶活性的细胞渗透性,可逆性和ATP竞争性抑制剂。 了解更多
  17. D-69491

    Catalog No. A15457
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    HER2 抑制剂
    D-69491 (SU11464)是一种小分子HER2抑制剂,正在开发中,用于治疗HER2高表达的肿瘤,例如乳腺癌,卵巢癌,肺癌和胰腺癌。 了解更多
  18. CL-387785 (EKI-785)

    Catalog No. A13146
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    EGFR 抑制剂
    CL-387785是EGFR的不可逆抑制剂,IC50为370+/-120 pM;能够在功能水平上克服由T790M突变引起的抗药性。 了解更多
  19. PD168393

    Catalog No. A12725
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    EGFR 抑制剂
    PD168393是一种有效的,细胞可渗透的,不可逆的EGFR抑制剂,IC50值为700 pM。 了解更多
  20. EAI045

    Catalog No. A16193
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    EGFR inhbitor
    EAI045是一种有效的选择性EGFR抑制剂。EAI045靶向选定的耐药性EGFR突变体,但保留了野生型受体。 了解更多
  21. Anlotinib

    Catalog No. A16253
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    EGFR 抑制剂
    Anlotinib是从专利2015185012 A1(化合物1)中提取的EGFR抑制剂,可用于治疗非小细胞肺癌。 了解更多
  22. PD158780

    Catalog No. A16254
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    EGFR 抑制剂
    PD158780是一种非常有效的EGFR抑制剂,IC50为0.08 nM。泛特异性的ErbB受体拮抗剂。 了解更多
  23. TX1-85-1

    Catalog No. A16361
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    Her3 (ErbB3) ligand
    TX1-85-1是ErbB3抑制剂。TX2-121-1可能通过变构机制发挥Her3依赖的药理作用,从而破坏Her3与其他蛋白质(例如Her3或cMet)之间的相互作用,与此处介绍的结果一致,并且与阻断催化功能的常规激酶抑制剂不同。 了解更多
  24. ARRY-380 (Irbinitinib)

    Catalog No. A16413
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    HER2 抑制剂
    ARRY-380是人表皮生长因子受体酪氨酸激酶ErbB-2(也称为HER2)的口服生物利用抑制剂,具有潜在的抗肿瘤活性。 了解更多
  25. AG-1517

    Catalog No. A13001
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    EGFR 抑制剂
    AG 1517是表皮生长因子受体酪氨酸激酶EGFR的有效和选择性ATP竞争性抑制剂。 了解更多
  26. AV412

    Catalog No. A15460
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    EGFR 抑制剂
    AV-412 (MP412)是一种EGFR抑制剂,对EGFR,EGFRL858R,EGFRT790M,EGFRL858R/T790M和ErbB2的IC50分别为0.75、0.5、0.79、2.3、19 nM。 了解更多
  27. Avitinib (AC0010)

    Catalog No. A16826
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    irreversible EGFR 抑制剂
    Avitinib (AC0010)是一种基于吡咯并嘧啶的不可逆EGFR抑制剂,对EGFR L858R/T790M双重突变具有突变选择性,IC50值为0.18 nM,效力比野生型EGFR(IC50值为7.68 nM)高近43倍。它具有可比的抗肿瘤活性和耐受的毒性。 了解更多
  28. Lazertinib (YH25448,GNS-1480)

    Catalog No. A16827
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    EGFR 抑制剂
    Lazertinib (YH25448,GNS-1480)是一种有效的,高度突变选择性和不可逆的EGFR-TKI,对于Del19/T790M,L858R/T790M,Del19,Del19,IC50值分别为1.7 nM,2 nM,5 nM,20.6 nM和76 nM。L85R和野生型EGFR分别显示出更高的IC50值,即抗药性ErbB2和ErbB4。 了解更多
  29. Tyrphostin AG-528

    Catalog No. A17072
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    EGFR 抑制剂
    Tyrphostin AG-528,也称为Tyrphostin B66,是EGFR蛋白酪氨酸激酶抑制剂。 了解更多
  30. Pyrotinib Racemate

    Catalog No. A17068
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    EGFR/HER2 dual 抑制剂
    Pyrotinib Racemate是吡罗替尼的外消旋体。吡罗替尼是一种有效的选择性EGFR/HER2双重抑制剂。 了解更多
    • 最新产品

    AG-494

    Catalog No. A17142
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    EGFR 抑制剂
    AG-494是表皮生长因子受体激酶的抑制剂,在HT-22细胞中的IC50值为1μM。 了解更多
  31. Lavendustin A

    Catalog No. A17119
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    EGFR 抑制剂
    Lavendustin A是表皮生长因子(EGF)受体相关酪氨酸激酶的选择性抑制剂,IC50值为11 nM。 了解更多
  32. AG-99

    Catalog No. A17123
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    EGFR 抑制剂
    AG-99是一种表皮生长因子受体(EGFR)激酶抑制剂,IC50值为10μM。 了解更多
  33. AG 555

    Catalog No. A18337
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    EGFR 抑制剂
    AG555 is a potent epidermal growth factor receptor (EGFR) kinase inhibitor. 了解更多
  34. RG14620

    Catalog No. A18327
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    EGFR 抑制剂
    RG14620 is an EGFR inhibitor with an IC50 of 3 μM. 了解更多
  35. MTX-211

    Catalog No. A18324
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    EGFR/PI3K 双重抑制剂
    MTX-211 is a dual inhibitor of EGFR and PI3K, which plays important roles in the progression of KRAS mutant colorectal cancer. MTX-211 has the potential for the treatment of KRAS mutant colorectal cancer. 了解更多
  36. DBPR112

    Catalog No. A18857
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    EGFR 抑制剂
    DBPR112 is an orally active Furanopyrimidine-Based Epidermal Growth Factor Receptor inhibitor with IC50s of 15 nM and 48 nM for EGFRWT and EGFRL858R/T790M, respectively. 了解更多
  37. EGFR-IN-7

    Catalog No. A18562
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    EGFR 抑制剂
    EGFR-IN-7 (compound 34) is a selective and potent EGFR kinase inhibitor extracted from patent WO2019015655A1, has IC50s of 7.92 nM and 0.218 nM for EGFR (WT) and EGFR (mutant C797S/T790M/L858R) respectively, and shows anti-tumor activity. 了解更多
  38. Mutated EGFR-IN-2

    Catalog No. A18565
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    EGFR 抑制剂
    Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=??1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity. 了解更多
  39. Genistein

    Catalog No. A10425
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    EGFR inhibitor
    Genistein, a soy isoflavone, is a multiple tyrosine kinases (e.g., EGFR) inhibitor which acts as a chemotherapeutic agent against different types of cancer, mainly by altering apoptosis, the cell cycle, and angiogenesis and inhibiting metastasis. 了解更多
  40. NSC 228155

    Catalog No. A16638
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    EGFR activator
    NSC 228155 is an activator of EGFR, binds to the extracellular region of EGFR and enhance tyrosine phosphorylation of EGFR. 了解更多
  41. Epertinib

    Catalog No. A13777
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    EGFR/HER2/HER4 inhibitor
    Epertinib is a potent, oral, reversible, and selective tyrosine kinase inhibitor of EGFR, HER2 and HER4, with IC50s of 1.48 nM, 7.15 nM and 2.49 nM, respectively. Epertinib shows potent antitumor activity. 了解更多
  42. EGFR-IN-2

    Catalog No. A12628
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    EGFR inhibitor
    EGFR-IN-2 is a a noncovalent, irreversible, mutant-selective second generation EGFR inhibitor. 了解更多
  43. CHMFL-EGFR-202

    Catalog No. A12524
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    EGFR inhibitor
    CHMFL-EGFR-202 is a potent, irreversible inhibitor of epidermal growth factor receptor (EGFR) mutant kinase, with IC50s of 5.3 nM and 8.3 nM for drug-resistant mutant EGFR T790M and WT EGFR kinases, respectively. 了解更多
  44. EGFR-IN-3

    Catalog No. A15847
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    EGFR inhibitor
    EGFR-IN-3 is an epidermal growth factor receptor (EGFR) inhibitor. 了解更多
  45. Canertinib dihydrochloride

    Catalog No. A11344
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    EGFR inhibitor
    Canertinib dihydrochloride (CI-1033 dihydrochloride) is a potent and irreversible EGFR inhibitor; inhibits cellular EGFR and ErbB2 autophosphorylation with IC50s of 7.4 and 9 nM. 了解更多
  46. Afatinib

    Catalog No. A18014
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    EGFR inhibitor
    Afatinib (BIBW 2992) is an irreversible EGFR family inhibitor with IC50s of 0.5 nM, 0.4 nM, 10 nM and 14 nM for EGFRwt, EGFRL858R, EGFRL858R/T790M and HER2, respectively. 了解更多
  47. Tarloxotinib bromide

    Catalog No. A20849
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    EGFR/HER2 inhibitor
    Tarloxotinib bromide (TH-4000) is an irreversible EGFR/HER2 inhibitor. 了解更多
  48. Mutant EGFR inhibitor

    Catalog No. A21144
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    EGFR inhibitor
    Mutant EGFR inhibitor is a potent and selective mutant EGFR inhibitor extracted from patent WO 2013014448 A1; inhibits EGFRL858R, EGFRExon 19 deletion and EGFRT790M. 了解更多
  49. HS-10296 hydrochloride

    Catalog No. A21661
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    EGFR/T790M inhibitor
    HS-10296 hydrochloride is an orally available and third-Generation inhibitor of epidermal growth factor receptor (EGFR)-activating mutations and T790M-resistant mutation with limited activity against wild-type EGFR. 了解更多

产品 51 到 100 共 428个

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