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AM 114是硼查尔酮的衍生物，是一种有效的蛋白酶体小分子抑制剂，可抑制20S蛋白酶体的胰凝乳蛋白酶样活性，其50％抑制浓度的IC50值约为1 uM，导致大量积累 泛素化的p53和其他细胞蛋白在整个细胞中的表达，而不会显着破坏p53与鼠类double minutes 2（mdm2）蛋白的相互作用。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.52 mL | 132.62 mL | 265.24 mL |
| 0.5 mM | 5.3 mL | 26.52 mL | 53.05 mL |
| 1 mM | 2.65 mL | 13.26 mL | 26.52 mL |
| 5 mM | 0.53 mL | 2.65 mL | 5.3 mL |
*The above data is based on the productmolecular weight 377.01. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A14922 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 377.01 |
| Formula | C20H21B2NO5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 856849-35-9 |
| SMILES | B(C1=CC=C(C=C1)C=C2CN(CC(=CC3=CC=C(C=C3)B(O)O)C2=O)C)(O)O |
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