GPCR19 (GPBA receptors, TGR5, GPBAR1, M-BAR) are G protein-coupled receptors (GPCRs) that are activated by bile acids. They are highly expressed in the gallbladder, ileum, and colon, and are important in the regulation of glucose and lipid metabolism, and energy utilization. Diseases associated with GPBAR1 include Sclerosing Cholangitis and Intrahepatic Cholestasis Of Pregnancy. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. Gene Ontology (GO) annotations related to this gene include G protein-coupled receptor activity and G protein-coupled bile acid receptor activity.
Catalog No. A12759TGR5 agonistSB756050 is a selective TGR5 agonist currently in phase 1clinical trials for the treatment of type 2 diabetes. 了解更多
Catalog No. A21168TGR5 agonistINT-777 is a potent TGR5 agonist with an EC50 of 0.82 μM. 了解更多
Catalog No. A21494dual FXR/TGR5 agonistINT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多
Catalog No. A13732TGR5(GPCR19) 激动剂TGR5 Receptor Agonist是一种有效的TGR5（GPCR19）激动剂，在U2-OS细胞分析（pEC50 = 6.8）和黑素细胞（pEC50 = 7.5）中显示出增强的效力。 了解更多
Catalog No. A17235GPCR19 antagonistSBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5. 了解更多