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PARP

Inhibitory Selectivity
Catalog No.Inhibitor Name PARPPARP1PARP2PARP3V-PARPTankyrase-1
A10111Olaparib
***
****
*
A10026Veliparib
***
***
A14182Rucaparib
****
A11243Talazoparib
****
A10046AG-14361
***
A10475INO-1001
**
A10019A-966492
****
****
A15215PJ34
***
A12665PJ34 HCl
***
A11026Niraparib
***
****
*
**
**
A12750UPF 1069
*
**
A14309ME0328
*
**
A14371Benzamide
*
A15375NU1025
**
A10164Iniparib
A12393AZD2461
A16344BGP-15
A10045AG-014699 (Rucaparib)
****
A153704-HQN
*
A15371BYK 204165
*
*
A15372BYK 49187
*
*
A15374EB 47
**
A15373DR 2313
*
**

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A13731 SALE

JW 55

TNKS1/2 抑制剂
JW 55 is an inhibitor of the PARP domain of tankyrase 1 and 2 (TNKS1/2).
A15873 SALE

AZ6102

TNKS1/2 抑制剂
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows IC50 of 5 nM for Wnt pathway inhibition in DLD-1 cells.
A15927

MN-64

TNKS 抑制剂
MN-64 is a potent and selective inhibitor of Tankyrase 1 and 2 (IC50 = 6 and 72 nM, respectively).
A15786

NVP-TNKS656

TNKS2 抑制剂
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
A15528 SALE

G007-LK

TNKS 抑制剂
G007-LK displays high selectivity toward tankyrases 1 and 2 with biochemical IC50 values of 46 nM and 25 nM, respectively, and a cellular IC50 value of 50 nM combined with an excellent pharmacokinetic profile in mice,
A15375

NU 1025

PARP 抑制剂
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
A15374

EB 47

PARP1 抑制剂
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
A15373

DR 2313

PARP 抑制剂
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
A15372

BYK 49187

PARP-1/PARP-2 抑制剂
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
A15371

BYK 204165

PARP-1 抑制剂
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
A15370

4-HQN

PARP 抑制剂
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
A12393 SALE

AZD-2461

PARP 抑制剂
AZD2461 is a novel and potent PARP inhibitor with lower affinity to P-glycoprotein.
A14182 SALE

Rucaparib

PARP-1 抑制剂
Rucaparib is a potent inhibitor of purified full-length human PARP-1 and shows higher inhibition of cellular PARP in LoVo and SW620 cells.
A14283

WIKI4

Tankyrase 抑制剂
WIKI4 is a novel Tankyrase inhibitor with IC50 of 15 nM for TNKS2.
A14309

ME0328

PARP3 抑制剂
ME0328 is a potent and selective PARP inhibitor with IC50 of 0.89 μM for PARP3, about 7-fold selectivity over PARP1.
A14371

Benzamide

PARP-1 抑制剂
Benzamide is the amide derivative of benzoic acid and an inhibitor of poly(ADP-ribose) polymerase-1 (PARP-1).
A14986

AIM-100

Ack1 (TNK2) 抑制剂
AIM-100 is a small molecule inhibitor of Ack1 with an IC50 of 24 nM.
A15024

BMN-673 8R,9S

PARP 抑制剂
BMN-673 (8R,9S) is the (8R,9S) enantiomer of BMN-673. BMN 673 is a novel PARP inhibitor with IC50 of 0.58 nM.
A15215 SALE

PJ34

PARP 抑制剂
PJ34 is a novel potent specific inhibitor of PARP-l/2 with EC50 of 20 nM.
A11454

TC-E 5001

TNKS 抑制剂
TC-E 5001 is dual tankyrase (TNKS) inhibitor (Kd values are 79 and 28 nM for TNKS1 and TNKS2 respectively, IC50 = 33 nM for TNKS2) that is devoid of activity at PARP1 and PARP2 (IC50 >19 uM). Inhibits Wnt signaling and stabilizes Axin2 levels.
A12750 SALE

UPF 1069

PARP2 抑制剂
UPF 1069 is a selective poly(ADP-ribose) polymerase (PARP) 2 inhibitor (IC50 values are 0.3 and 8.0 μM for PARP-2 and PARP-1 respectively).
A12665 SALE

PJ 34 hydrochloride

PARP 抑制剂
PJ 34 hydrochloride is a potent inhibitor of poly(ADP-ribose) polymerase (PARP) (EC50 = 20 nM).
A10026

ABT-888 (Veliparib)

PARP 抑制剂
ABT-888(Veliparib) is a potential anti-cancer drug acting as a PARP inhibitor.
A10111 SALE

Olaparib (AZD2281)

PARP 抑制剂
Olaparib (AZD2281) is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme involved in DNA repair.
A10164 SALE

BSI-201 (Iniparib)

PARP 抑制剂
BSI-201 is a potent inhibitor of PARP-1 and has been shown to cross the blood-brain barrier.
A10045 SALE

AG-014699 (Rucaparib)

PARP 抑制剂
AG-014699 (Rucaparib) is a PARP inhibitor that inhibits poly(ADP-ribose) polymerase (PARP) is a key enzyme in DNA repair.
A10046 SALE

AG14361

PARP 抑制剂
AG14361 is a potent PARP inhibitor, enhanced Temozolomide (TMZ) cytotoxicity in MMR(mismatch repair)-proficient / deficient cells.
A10475

INO-1001

PARP 抑制剂
INO-1001 is a novel PARP inhibitor, known to sensitize cells to radiation in vitro by inhibiting the repair of DNA damage.
A10019 SALE

A-966492

PARP1 抑制剂
A-966492 displayed high potency against the poly(ADP-ribose) polymerase-1 (PARP-1) enzyme with a K(i) of 1 nM and an EC(50) of 1 nM in a whole cell assay.
A11026 SALE

MK-4827 (Niraparib)

PARP 抑制剂
MK-4827 is a novel potent, orally bioavailable PARP-1 and PARP-2 inhibitor.
A11243 SALE

BMN673

PARP 抑制剂
BMN-673 is an orally bioavailable inhibitor of the nuclear enzyme poly(ADP-ribose) polymerase (PARP) with potential antineoplastic activity.
A16344

BGP-15

PARP 抑制剂
BGP-15 is a PARP inhibitor, that can protect against heart failure and atrial fibrillation in mice.

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