R406 (Tamatinib)

Name: R406 (Tamatinib)
SKU: A10770

目录号: A10770

Syk 抑制剂

R406 (Tamatinib) Chemical Structure

CAS NO. 841290-80-0

R406 (Tamatinib)是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。

库存：现货

规格	价格	数量
10 mg	￥ 1,500.00
25 mg	￥ 2,800.00
50 mg	￥ 5,000.00
100 mg	￥ 8,800.00
10mM * 1mL in DMSO	￥ 1,300.00

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生物活性

R406 (Tamatinib)是一种口服酪氨酸激酶抑制剂，IC50为41 nM。对Syk抑制作用强，但是不抑制Lyn，对Flt3的作用比对Syk低5倍。

靶点信息

Syk (Cell-free assay)
41 nM

溶解度 *

In vitro (25°C)	DMSO	18 mg/mL (38.25 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	1% DMSO+30% polyethylene glycol+1% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.25 mL	106.27 mL	212.54 mL
0.5 mM	4.25 mL	21.25 mL	42.51 mL
1 mM	2.13 mL	10.63 mL	21.25 mL
5 mM	0.43 mL	2.13 mL	4.25 mL

*The above data is based on the productmolecular weight 470.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10770
作用机制	Inhibitor (抑制剂)
M. Wt	470.5
Formula	C22H23FN6O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	841290-80-0
Synonyms	R-406
SMILES	CC1(C(=O)NC2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)C