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R935788 (Fostamatinib disodium, R788)

R935788 (Fostamatinib disodium, R788)

Name: R935788 (Fostamatinib disodium, R788)
SKU: A10771

目录号: A10771

Syk 抑制剂

R935788 (Fostamatinib disodium, R788) Chemical Structure

CAS NO. 1025687-58-4

R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。

库存：现货

规格	价格	数量
5 mg	￥ 900.00
10 mg	￥ 1,300.00
50 mg	￥ 4,000.00
100 mg	￥ 6,380.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

R935788 (Fostamatinib disodium,R788)是一种有效的口服Syk抑制剂，可通过阻断抗原依赖性B细胞受体信号传导来抑制CLL的Eμ-TCL1转基因小鼠模型中的肿瘤生长。

靶点信息

Syk (Cell-free assay)
41 nM

溶解度 *

In vitro (25°C)	DMSO	Warmed: 5 mg/mL (8 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% CMC+0.25% Tween 80,pH6.5	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	16.02 mL	80.08 mL	160.15 mL
0.5 mM	3.2 mL	16.02 mL	32.03 mL
1 mM	1.6 mL	8.01 mL	16.02 mL
5 mM	0.32 mL	1.6 mL	3.2 mL

*The above data is based on the productmolecular weight 624.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10771
作用机制	Inhibitor (抑制剂)
M. Wt	624.4
Formula	C23H24FN6O9P.2Na
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1025687-58-4
Synonyms	R-935788, Fostamatinib disodium, R788
SMILES	CC1(C(=O)N(C2=C(O1)C=CC(=N2)NC3=NC(=NC=C3F)NC4=CC(=C(C(=C4)OC)OC)OC)COP(=O)([O-])[O-])C.[Na+].[Na+]