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TX1-85-1是ErbB3抑制剂。TX2-121-1可能通过变构机制发挥Her3依赖的药理作用，从而破坏Her3与其他蛋白质（例如Her3或cMet）之间的相互作用，与此处介绍的结果一致，并且与阻断催化功能的常规激酶抑制剂不同。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 17.22 mL | 86.1 mL | 172.21 mL |
| 0.5 mM | 3.44 mL | 17.22 mL | 34.44 mL |
| 1 mM | 1.72 mL | 8.61 mL | 17.22 mL |
| 5 mM | 0.34 mL | 1.72 mL | 3.44 mL |
*The above data is based on the productmolecular weight 580.69. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16361 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 580.69 |
| Formula | C32H36N8O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1603845-32-4 |
| Synonyms | TX1 85-1, TX185-1, TX1851, TX 1851, TX-1851 |
| SMILES | C=CC(NC1=CC(C2=NN(C3CCC(N4CCN(C(C)=O)CC4)CC3)C5=NC=NC(N)=C52)=CC=C1OC6=CC=CC=C6)=O |
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