AR-A 014418

Name: AR-A 014418
SKU: A13728

目录号: A13728

GSK-3 抑制剂

Product Citations (1)

AR-A 014418 Chemical Structure

CAS NO. 487021-52-3

AR-A 014418是一种选择性糖原合酶激酶3 (GSK-3) 抑制剂 (IC50 = 104 nM)。对GSK-3的特异性超过cdk2和cdk5（IC50值> 100μM）以及26种其他激酶。抑制β-淀粉样蛋白介导的海马片神经变性。

库存：现货

规格	价格	数量
10 mg	￥ 600.00
25 mg	￥ 1,200.00
50 mg	￥ 2,000.00
100 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 600.00

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生物活性

靶点信息

GSK-3β (Cell-free assay)	GSK-3β (Cell-free assay)
38 nM(Ki)	38 nM(Ki)

溶解度 *

In vitro	DMSO	55 mg/mL (178.39 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	32.43 mL	162.17 mL	324.35 mL
0.5 mM	6.49 mL	32.43 mL	64.87 mL
1 mM	3.24 mL	16.22 mL	32.43 mL
5 mM	0.65 mL	3.24 mL	6.49 mL

*The above data is based on the productmolecular weight 308.31. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13728
作用机制	Inhibitor (抑制剂)
M. Wt	308.31
Formula	C12H12N4O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	487021-52-3
Synonyms	AR-A014418, ARA 014418, ARA014418
SMILES	COC1=CC=C(C=C1)CNC(=O)NC2=NC=C(S2)[N+](=O)[O-]