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LY 341495已被证明是一种高效的选择性II类代谢型谷氨酸受体(mGluR-2)拮抗剂，对于人类mGluR-2，mGluR，Ki/IC50值分别为2.3、1.3、173、990、6800、8200和22000 nM。mGluR-3，mGluR-8，mGluR-7a，mGluR-1a，mGluR-5a和mGluR-4a。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 28.3 mL | 141.49 mL | 282.99 mL |
| 0.5 mM | 5.66 mL | 28.3 mL | 56.6 mL |
| 1 mM | 2.83 mL | 14.15 mL | 28.3 mL |
| 5 mM | 0.57 mL | 2.83 mL | 5.66 mL |
*The above data is based on the productmolecular weight 353.37. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11484 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 353.37 |
| Formula | C20H19NO5 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 201943-63-7 |
| SMILES | C1[C@@H]([C@H]1[C@@](CC2C3=CC=CC=C3OC4=CC=CC=C24)(C(=O)O)N)C(=O)O |
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