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UK 5099是质膜单羧酸盐转运蛋白（MCT）和线粒体丙酮酸载体（MPC）的有效抑制剂。抑制丙酮酸依赖性的氧气消耗，IC50为50 nM。
| In vitro | DMSO | 54 mg/mL (187.3 mM) | |
| Water | Insoluble | ||
| Ethanol | <1 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.69 mL | 173.43 mL | 346.86 mL |
| 0.5 mM | 6.94 mL | 34.69 mL | 69.37 mL |
| 1 mM | 3.47 mL | 17.34 mL | 34.69 mL |
| 5 mM | 0.69 mL | 3.47 mL | 6.94 mL |
*The above data is based on the productmolecular weight 288.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13038 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 288.3 |
| Formula | C18H12N2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 56396-35-1 |
| Synonyms | PF-1005023, UK5099, UK-5099, PF1005023, PF 1005023 |
| SMILES | C1=CC=C(C=C1)N2C=C(C3=CC=CC=C32)C=C(C#N)C(=O)O |
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