GSK1120212 (JTP-74057, Trametinib)

目录号: A11029

MEK 抑制剂

GSK1120212 (JTP-74057, Trametinib)

GSK1120212 (JTP-74057, Trametinib) Chemical Structure

CAS NO. 871700-17-3

GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性,而不是其他98种激酶的活性。

库存: 现货

规格 价格 数量
5 mg
¥ 400.00
10 mg
¥ 600.00
50 mg
¥ 800.00
100 mg
¥ 1,200.00
10mM * 1mL in DMSO
¥ 550.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

GSK1120212 (JTP-74057,Trametinib)强烈阻止了MEK1和MEK2激酶的活性,而不是其他98种激酶的活性。
靶点信息
MEK1 (Cell-free assay) MEK2 (Cell-free assay)
0.92 nM1.8 nM
In vitro (25°C) DMSO Warmed: 19 mg/mL (30.87 mM)
Water Insoluble
Ethanol Insoluble
In vivo 4% DMSO+corn oil 2 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 16.25 mL 81.25 mL 162.5 mL
0.5 mM 3.25 mL 16.25 mL 32.5 mL
1 mM 1.62 mL 8.12 mL 16.25 mL
5 mM 0.32 mL 1.62 mL 3.25 mL

*The above data is based on the productmolecular weight 615.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A11029
作用机制 Inhibitor (抑制剂)
M. Wt 615.4
Formula C26H23FIN5O4
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 871700-17-3
Synonyms GSK-1120212, GSK212, Trametinib
SMILES CC1=C2C(=C(N(C1=O)C)NC3=C(C=C(C=C3)I)F)C(=O)N(C(=O)N2C4=CC(=CC=C4)NC(=O)C)C5CC5

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