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JNK/c-Jun

Inhibitory Selectivity
Catalog No.Inhibitor Name JNK1JNK2JNK3JNKOther
A10860SP600125
***
***
*
Aurora A,TrkA,FLT3
A12749JNK-IN-8
****
***
****
Kit (V559D,T670I),Kit (V559D),RIOK2
A11969JNK Inhibitor IX
*
**
A11296AS 602801 (Bentamapimod)
**
**
*
A13564CC-930 ( Tanzisertib)
**
***
****
A13565CEP-1347
***
A13683BI-78D3
*
A11352CC-401
A15061DB07268
****
A15136JNK-IN-7
IRAK1, PIK3C3, PIP5K3 and PIP4K2C
A16036IQ 3
*
*
**
NF-κB, AP1
A16039SU 3327
*
A16054TCS JNK 6o
****
****
**
A16062 IQ-1S
*
*
**
A15883Vacquinol-1

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



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Catalog No. Product Name Application Product Information
A12749

JNK-IN-8

JNK 抑制剂
JNK-IN-8 is the first irreversible JNK inhibitor for JNK1, JNK2 and JNK4 with IC50 of 4.7 nM, 18.7 nM and 1 nM, respectively
A16059

DTP3

JNK 抑制剂
DTP3 is a selective GADD45β/MKK7 inhibitor, which inhibits cancer-selective NF-kB survival pathway.
A16054

TCS JNK 6o

JNK 抑制剂
TCS JNK 6o is a ATP-competitive and selective c-Jun N-terminal kinase (JNK) inhibitor.
A16041

JIP-1 (153-163)

JNK 抑制剂
JIP-1 (153-163) is a peptide inhibitor of c-Jun N-terminal kinase (JNK), based on residues 153-163 of JNK-interacting protein-1 (JIP-1). Binds to JNK with affinity in the micromolar range and minimally inhibits p38 and ERK.
A16039

SU 3327

JNK 抑制剂
SU 3327 is a selective inhibitor of JNK (c-Jun N-terminal kinase)(IC50 = 0.7uM). SU 3327 is shown to inhibit the protein-protein interaction between JNK and JIP (IC50 = 239 nM).
A16036

IQ 3

JNK3 抑制剂
IQ 3 is a selective JNK3 inhibitor (Kd values are 66, 240 and 290 nM for JNK3, JNK1 and JNK2 respectively). Inhibits NF-kB/AP1 transcriptional activity in THP1-Blue cells (IC50 = 1.4 μM). Also inhibits TNF-α and IL-6 production in vitro.
A11281

AEG 3482

JNK 抑制剂
AEG 3482 is a small-molecule inhibitor of Jun kinase (JNK)-dependent apoptosis.
A15136

JNK-IN-7

JNK 抑制剂
JNK-IN-7 is a relatively selective JNKs inhibitor(IC50= 1.54/1.99/0.75 for JNK1/2/3); also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C.
A13683

BI-78D3

JNK 抑制剂
BI-78D3 is a competitive JNK (c-Jun N-terminal kinases) inhibitor (IC50 = 280 nM) that displays > 100 fold selectivity over p38?? and no activity at mTOR and PI-3K. BI 78D3 inhibits JIP1(JNK interacting protein 1)-JNK binding (IC50 = 500 nM).
A13564

CC-930 (Tanzisertib)

JNK 抑制剂
CC-930 is kinetically competitive with ATP in the JNK-dependent phosphorylation of the protein substrate c-Jun and potent against all isoforms of JNK (Ki(JNK1) = 44 ± 3 nM, IC50(JNK1) = 61 nM, Ki(JNK2) = 6.2 ± 0.6 nM, IC50(JNK2) = 5 nM, IC50(JNK3) = 5 nM) and selective against MAP kinases ERK1 and p38a with IC50 of 0.48 and 3.4 μM respectively
A13565

CEP-1347

JNK 抑制剂
CEP-1347 is an inhibitor of c-jun N-terminal kinase (JNK) signaling. It rescues motor neurons undergoing apoptosis (EC50 = 20 nM).
A15037

CC-401 hydrochloride

JNK 抑制剂
CC-401 hydrochloride is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A15061

DB07268

JNK1 抑制剂
DB07268 is a potent and selective JNK1 inhibitor with an IC50 value of 9 nM.
A16020

SR 3576

JNK3 抑制剂
SR 3576 is a highly potent and selective JNK3 inhibitor (IC50 = 7 nM); exhibits > 2800-fold selectivity over p38.
A11271

Anisomycin

SAPKs/JNKs activator
Anisomycin is a pyrrolidine antibiotic, acts as an anti-fungal antibiotic which inhibits Protein Synthesis, also is a potent activator of SAPKs/JNKs.
A16062 SALE

IQ-1S

JNK3 抑制剂
IQ-1S is a Selective JNK3 inhibitor with IC50 value of 390, 360 and 87 nM for JNK1, 2 and 3 respectively.
A15883

Vacquinol-1

MKK4-dependent macropinocytotic Activator
Vacquinol-1 is an MKK4 activator, which rapidly and selectively induces glioma cell death.
A11969 SALE

TCS JNK 5a

JNK 抑制剂 IX
TCS JNK 5a is a highly selective inhibitor of JNK2 and JNK3 (pIC50 values are 6.7, 6.5, <5.0 and <4.8 for JNK3, JNK2, JNK1 and p38?? respectively).
A11352 SALE

CC-401

JNK 抑制剂
CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity.
A11296 SALE

AS 602801 (Bentamapimod)

JNK 抑制剂
AS 602801 is a novel, orally active, Jun Kinase Inhibitor.
A10860 SALE

SP600125

JNK 抑制剂
SP600125 is a JNK inhibitor with IC50=40 nM for JNK-1 and JNK-2 and 90 nM for JNK-3.
A16045

c-JUN peptide

JNK 抑制剂
c-JUN peptide is a peptide comprising residues 33 - 57 of the JNK binding (δ) domain of human c-Jun.

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