TRPV

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  1. SB-705498

    Catalog No. A11143
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    TRPV1 拮抗剂
    SB-705498是有效,选择性和口服生物利用的TRPV1拮抗剂,抑制TRPV1的Capsaicin,酸和热激活,IC50分别为3 nM, 0.1 nM和6 nM,该作用具有一定的电压依赖性,作用于TRPV1比作用于TRPM8选择性高100倍以上。 了解更多
  2. AMG517

    Catalog No. A12727
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    TRPV1 拮抗剂
    AMG 517是有效的选择性TRPV1拮抗剂。 了解更多
  3. A-889425

    Catalog No. A13497
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    TRPV1 receptor 拮抗剂
    A-889425是选择性TRPV1受体拮抗剂。A-889425阻断TRPV1通道,IC50为335 nM(大鼠)和34 nM(人)。 了解更多
  4. Linoleyl ethanolamide

    Catalog No. A15496
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    Linoleyl ethanolamide是一种内源性大麻素,也与TRPV1结合(Ki = 5.60 uM)。 了解更多
  5. MRS1477

    Catalog No. A15498
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    TRPV1 modulator
    MRS1477是TRPV1阳性变构调节剂。 了解更多
  6. Mavatrep

    Catalog No. A15778
    TRPV1 拮抗剂
    Mavatrep是生物利用的TRPV1拮抗剂(Ki = 6.5 nM),对CYP亚型3A4、1A2和2D6的酶活性(IC50> 25μM)影响很小。 了解更多
  7. SB366791

    Catalog No. A15857
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    TRPV1 receptor 拮抗剂
    SB-366791是新颖,有效且选择性的肉桂酰胺TRPV1拮抗剂。 了解更多
  8. Capsazepine

    Catalog No. A21208
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    TRPV1 receptor
    Capsazepine is a synthetic analogue of the sensory neurone excitotoxin, and an antagonist of TRPV1 receptor with an IC50 of 562 nM. 了解更多
  9. A-1165442

    Catalog No. A21516
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    TRPV1 antagonist
    A-1165442 is a potent, competitive and orally available TRPV1 antagonist with an IC50 of 9 nM for human TRPV1. 了解更多
  10. GSK-2193874

    Catalog No. A14201
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    TRPV4 blocker
    GSK2193874被确定为选择性的口服活性TRPV4阻滞剂,可通过重组TRPV4通道和天然内皮TRPV4电流抑制Ca(2+)流入。 了解更多
  11. Resiniferatoxin

    Catalog No. A14003
    vanilloid receptor 激动剂
    Resiniferatoxin是从大戟属(Euphorbia)属的一些植物中分离出的辣椒素的天然类似物(货号92350),包括E. resinifera。 了解更多
  12. GSK1016790A

    Catalog No. A15854
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    TRPV4 Activator
    GSK1016790A是一种新型有效的TRPV4激活剂(瞬态受体电位香草酸4),在脉络丛上皮细胞中的EC50为34nM。 了解更多
  13. (+)-Camphor

    Catalog No. A16423
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    (+)-Camphor是蜡状,易燃,白色或透明的固体,具有强烈的香气,通常用于缓解疼痛,减少瘙痒和治疗真菌感染。它可以激活TRPV1和TRPV3。 了解更多
  14. (Z)-Capsaicin

    Catalog No. A18179
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    TRPV1 agonist
    Zucapsaicin, also known as cis-Capsaicin, is a medication used to treat osteoarthritis of the knee and other neuropathic pain. It is applied three times daily for a maximum of three months. It reduces pain, and improves articular functions. 了解更多
  15. JNJ-17203212

    Catalog No. A12766
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    TRPV1 antagonist
    NJ-17203212 is a novel and selective TRPV1 antagonist, with IC50 of 65 nM and 102 nM for human TRPV1 and rat TRPV1. 了解更多

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