“Tutalthromycin second gen”的搜索结果
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estrogen receptor modulator
4-Hydroxytamoxifen is a selective estrogen receptor modulator (SERM).
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positive AMPAR modulator
CX546 is a selective positive AMPAR modulator; the prototypical ampakine agent.
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AMPA receptors allosteric modulator
PEPA is an allosteric modulator of AMPA receptors; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.
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estrogen receptor modulators
Pipendoxifene hydrochloride is a selective estrogen receptor modulators (SERMs).
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nuclear estrogen receptor modulator
Estetrol, a natural estrogen synthesized exclusively during pregnancy by the human fetal liver, is a selective nuclear estrogen receptor modulator.
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androgen receptor modulator
RAD140 is a potent, orally bioavailable, nonsteroidal selective androgen receptor modulator (SARM).
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androgen receptor modulator
GLPG0492 is a novel selective androgen receptor modulator; exhibited anabolic activity on muscle, strongly dissociated from the androgenic activity on prostate after oral dosing.
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selective estrogen receptor modulator (SERM)
Tamoxifen (ICI 47699) is a selective estrogen receptor modulator (SERM) which blocks estrogen action in breast cells and can activate estrogen activity in other cells, such as bone, liver, and uterine cells.
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HBV capsid assembly modulator
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.
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gp130 modulator
RCGD423 is a gp130 modulator, which prevents articular cartilage degeneration and promotes repair.
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selective Estrogen receptor modulator
Lasofoxifene tartrate is a third-generation selective estrogen receptor modulator.
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androgen receptor modulator (SARM)
LY2452473是一种口服生物利用型选择性雄激素受体调节剂(SARM),具有潜在的组织选择性雄激素/抗雄激素活性。
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androgen receptor modulator
GSK-2881078是一种选择性雄激素受体调节剂(SARM),正在针对肌肉萎缩以改善其身体功能的受试者的肌肉生长和力量进行评估。
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Neurogenic Modulator
ISX-9是成人神经干细胞分化的小分子诱导剂。
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Estrogen receptor modulator
Toremifene是正在开发中的第二代选择性雌激素受体调节剂(SERM),用于预防骨质疏松症。
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Androgen receptor modulator
MK-0773是一种选择性雄激素受体调节剂(SARMs),是一种4-氮杂-类固醇,在人体中表现出组织选择性(IC50 = 6.6 nM)。
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Estrogen modulator
Bazedoxifene是雌激素受体的第三代选择性调节剂。
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estrogen receptor modulator
Ospemifene是一种非激素选择性雌激素受体调节剂(SERM)。
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Androgen receptor (AR) modulator
BMS-564929是一种新型,高效,口服活性,非甾体组织选择性雄激素受体(AR)调节剂,结合到雄激素受体,Ki 为 2.11±0.16 nM。该化合物已被推进临床试验,以治疗与年龄相关的功能衰退。
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estrogen receptor modulator
Acolbifene (EM 652,SCH57068)是第四代选择性的estrogen receptor拮抗剂,LC50 值为 22±3 nM。用于预防高乳腺癌女性的乳腺癌。 盐酸阿科比芬与体内雌激素受体结合,阻断雌激素对乳房的作用。 它是选择性雌激素受体调节剂(SERM)的一种。
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- Sumit Bansal, .et al. Inhibition of Human Sulfotransferase 2A1-Catalyzed Sulfonation of Lithocholic Acid, Glycolithocholic Acid, and Taurolithocholic Acid by Selective Estrogen Receptor Modulators and Various Analogs and Metabolites, J Pharmacol Exp Ther, 2019, June, 369 (3) 389-405
- Lirit N. Franks, .et al. Selective Estrogen Receptor Modulators: Cannabinoid Receptor Inverse Agonists with Differential CB1 and CB2 Selectivity, Front Pharmacol, 2016, 7: 503 PMID: 28066250
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Androgen Receptor Modulators
Ostarine (MK-2866,GTX-024)是一种雄激素受体调节剂(SARM)。
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