您的购物车内没有物品。
New Products
Catalog No. | Product Name | Product Information |
---|---|---|
A11293 |
AR-C155858 |
AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10.
|
A12742 |
BAY 1000394 (Roniciclib) |
BAY 1000394 is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity.
|
A13192 |
IWP-3 |
IWP-3 is an inhibitor of Wnt production. Blocks Wnt pathway activity in vitro ( IC₅₀ = 40 nM). IWP-3 inactivates Porcupine (Porcn), a membrane-bound O-acyltransferase responsible for palmitoylating Wnt proteins, which is essential for their signaling ability and secretion. Through blockade of Wnt signaling, IWP-3 has been used to promote cardiomyocyte generation from human embryonic stem cells (EC₅₀ = 1.2 μM).
|
A13041 |
PST-2744 (Istaroxime) |
Istaroxime is a positive inotropic agent that mediates its action through inhibition of sodium/potassium adenosine triphosphatase (Na+/K+ ATPase).
|
A15263 |
Toceranib phosphate |
Toceranib phosphate is a kinase inhibitor with both antitumor and antiangiogenic activity through inhibition of KIT, vascular endothelial growth factor receptor 2, and PDGFRβ.
|
A15264 |
Toll-like receptor modulator |
Toll-like receptors (TLRs) are a class of proteins that play a key role in the innate immune system.
|
A15265 |
Toremifene |
Toremifene is a second-generation selective estrogen-receptor modulator (SERM) in development for the prevention of osteoporosis.
|
A15266 |
Trenbolone |
Trenbolone is a steroid used by veterinarians on livestock to increase muscle growth and appetite.
|
A15267 |
Tyrosine kinase inhibitor |
Tyrosine-kinase inhibitor is a pharmaceutical drug that inhibits tyrosine kinases. Tyrosine kinases are enzymes responsible for the activation of many proteins by signal transduction cascades.
|
A15268 |
Umeclidinium bromide |
Umeclidinium bromide(GSK573719A) is a muscarinic receptor antagonist which is useful in treatment of chronic obstructive pulmonary disease (COPD).
|
A15269 |
VAL-083 |
VAL-083 is a bi-functional alkylating agent; inhibit U251 and SF188 cell growth in monolayer better than TMZ and caused apoptosis.
|
A15270 |
Valaciclovir |
Valacyclovir is an antiviral drug used in the management of herpes simplex, herpes zoster, and herpes B.
|
A15271 |
Vandetanib HCl |
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
|
A15272 |
Vandetanib trifluoroacetate |
Vandetanib is a potent inhibitor of VEGFR2 with IC50 of 40 nM.
|
A15273 |
Vc-MMAD |
Vc-MMAD consists the ADCs linker(Val-Cit) and potent tubulin inhibitor (MMAD), Vc-MMAD is an antibody drug conjugate.
|
A15274 |
VD2-D3 |
VD2-D3 is a deuterated form of vitamin D.
|
A15276 |
Vicriviroc maleate |
Vicriviroc maleate is a CCR5 antagonist with IC50 of 0.91 nM in clinical development for the treatment of HIV-1.
|
A15277 |
Vigabatrin |
Vigabatrin is a structural analog of the inhibitory neurotransmitter ??-aminobutyric acid (GABA) that irreversibly inhibits the catabolism of GABA by GABA transaminase.
|
A15278 |
Vitamin D4 |
Vitamin D4 is the active analogue of Vitamin D.
|
A15279 |
VO-Ohpic trihydrate |
VO-Ohpic trihydrate is an inhibitor of PTEN (phosphatase and tensin homologue deleted on chromosome 10).
|
A15280 |
Voreloxin Hydrochloride |
Voreloxin Hcl is a small molecule and a naphthyridine analogue with antineoplastic activity; inhibitor of Topo II.
|
A15281 |
VTP-27999 2,2,2-trifluoroacetate |
VTP-27999 2,2,2-trifluoroacetate is an alkyl amine Renin inhibitor; VTP-27999 is useful for Hypertension and End-Organ Diseases.
|
A15282 |
WAY-100635 maleate salt |
WAY-100635 maleate is a potent and selective 5-hydroxytryptamine1A antagonist with an IC50 of 0.95 - 0.12 nM for 5-HT.
|
A15283 |
XL-147 (Pilaralisib) |
XL147 is a potent, orally bioavailable inhibitor of the class I PI3K family of lipid kinases.
|
A15284 |
YM-155 HCl |
YM-155 is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
|
A15285 |
Zaltidine |
Zaltidine is a H2-receptor antagonist, which has the antisecretory action.
|
A15287 |
ZM323881 |
ZM323881 is a potent and selective inhibitor of human vascular endothelial growth factor receptor 2 (VEGFR-2/KDR) with IC50 value of 2 nM.
|
A15289 |
Zosuquidar |
Zosuquidar is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM.
|
A15290 |
Acetyl-Calpastatin (184-210) (human) |
Acetyl-Calpastatin (184-210) (human), selective calpain inhibitor. Strongly inhibits calpain I (Ki = 0.2 nM) and II but does not inhibit papain, trypsin and cathepsin L (Ki = 6 uM). Increases secretion of amyoid ??-protein (A??) 42, A??40 and A??42 ratio.
|
A15291 |
Ac-LEHD-AFC |
Ac-LEHD-AFC, fluorogenic caspase substrate. Analog of the caspase-9 substrate, LEHD-AFC.
|
A15292 |
ARP 100 |
ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
|
A15293 |
ARP 101 |
ARP 101, selective inhibitor of MMP-2 that displays ~ 600-fold selectivity over MMP-1 (IC50 values are 0.81 and 486 nM respectively).
|
A15294 |
AZ 10417808 |
AZ 10417808, selective non-peptide inhibitor of caspase-3 (Ki = 247 nM); displays > 40-fold selectivity over caspases 1, 2, 6, 7 and 8 (Ki > 10 uM).
|
A15296 |
Compound W |
Compound W is a γ-secretase inhibitor that has been shown to lower the levels of secreted Aβ42 and Nβ25.
|
A15297 |
CP 471474 |
CP 471474, broad spectrum MMP inhibitor (IC50 values are 0.7, 0.9, 13, 16 and 1170 nM for MMP-2, MMP-13, MMP-9, MMP-3 and MMP-1 respectively).
|
A15298 |
DPPI 1c hydrochloride |
DPPI 1c hydrochloride is a dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of CD26 (DPP 4), with an IC50 = 106 nM and little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 μM.
|
A15299 |
Fumagillin |
Fumagillin is a complex natural product antibiotic which covalently binds a key histidine residue of methionine aminopeptidase type II (MetAP-2), inhibiting endothelial cell proliferation and angiogenesis.
|
A15300 |
Ivachtin |
Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
|
A15301 |
JLK 6 |
JLK 6 is an inhibitor of γ-secretase that selectively inhibits APP cleavage without affecting other γ-secretase-mediated pathways.
|
A15303 |
MDL 28170 |
MDL 28170 is a cell permeable selective inhibitor of Calpain 1, a Ca2+-dependent cysteine protease which has been implicated in apoptosis of immune cells as well as neuronal cells.
|
A15304 |
MRK 560 |
MRK 560 is an orally bioavailable gamma-secretase inhibitor with the ability to markedly reduce Abeta peptide in the brain and CSF of the rat and confirm the utility of the rat for assessing the effects of gamma-secretase inhibitors on central nervous system Abeta(40) levels in vivo.
|
A15305 |
ONO 4817 |
ONO 4817 is used for testing effective treatment of MMP-related diseases.
|
A15306 |
PD 150606 |
PD 150606 is a cell-permeable, non-competitive, selective, non-peptide Ca2+ dependent calpain inhibitor for calpain-1 and for calpain-2 directed towards the Ca2+ binding sites of calpain.
|
A15307 |
PD 166793 |
PD166793 is a cell-permeable compound that strongly inhibits MMP (matrix metalloproteinase) -2 , -3, and -13, and weakly inhibits AMP deaminase, MMP-1, -7, -9, and -14.
|
A15308 |
PETCM |
PETCM is an activator of caspase-3 and a stimulator of apoptosome formation in HeLa cell cytosols.
|
A15309 |
PK 44 phosphate |
PK 44 phosphate is a potent inhibitor of dipeptidyl peptidase IV (DPP-IV) with an IC50 value of 15.8 nM.
|
A15311 |
Ro 32-3555 |
Ro 32-3555 is a potent, collagenase-selective MMP inhibitor .
|
A15312 |
SC 57461A |
SC 57461A is a potent and competitive inhibitor of recombinant human leukotriene A4 hydrolase in vitro (Askonas et al., 2002).
|
A15313 |
SID 26681509 |
SID 26681509 is a reversible and potent human cathepsin L inhibitor. SID 26681509 displays no inhibitory activity of cathepsin G.
|
A15314 |
Spinorphin |
Spinorphin is an endogenous factor that exhibits inhibitory effects on enkephalin-degrading enzymes.
|
A15315 |
SSR 69071 |
SSR 69071 is a high affinity, potent inhibitor of Neutrophil Elastase (human leukocyte elastase, HLE) (IC50 = 3.9 nM).
|
A15316 |
UK 370106 |
UK 370106 is a highly selective MMP-3 and MMP-12 inhibitor .
|
A15317 |
WAY 170523 |
WAY 170523 has been reported to be a selective and potent inhibitor of MMP-13.
|
A15318 |
ZJ 43 |
ZJ 43 is a potent inhibitor of PSM and PSMAL (glutamate carboxypeptidase II and III).
|
A15319 |
Ac-IEPD-AFC |
Ac-LEHD-AFC is a fluorogenic substrate for caspase-4, caspase-5, and caspase-9.
|
A15320 |
NVP DPP 728 dihydrochloride |
NVP DPP 728 dihydrochloride is a potent and orally active inhibitor of dipeptidyl peptidase (DPP)-IV with Ki and IC50 values of 11 nM and 14 nM, respectively.
|
A15321 |
Vialinin A |
Vialinin A is a terphenyl compound originally isolated from the fungi T. terrestris and T. vialis.
|
A15322 |
GI 254023X |
GI 254023X is a selective ADAM10 metalloprotease inhibitor; displays over 100-fold higher potency at ADAM10 compared to ADAM17.
|
A15323 |
UK 356618 |
UK 356618 is a selective and potent inhibitor of MMP-3 that shows selectivity over a range of MMPs.
|
A15324 |
4-Chlorophenylguanidine hydrochloride |
4-Chlorophenylguanidine hydrochloride is a potent and specific inhibitor of uPA (urokinase).
|
A15325 |
BC 11 hydrobromide |
BC 11 hydrobromide, belective urokinase (uPA) inhibitor (IC50 = 8.2 μM). Inhibits clot lysis with no effect on clot formation and exhibits no activity at 8 other uPA related enzymes.
|
A15327 |
Necrostatin 2 racemate |
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
|
A15328 |
Necrostatin 2 S enantiomer |
Necrostatin 2 is a potent necroptosis inhibitor with EC50 of 50 nM.
|
A15329 |
R18 |
R18, antagonist of 14.3.3 proteins (KD ≈ 80 nM). Competitively inhibits 14.3.3-ligand interactions without requiring phosphorylation.
|
A15330 |
2,3-DCPE hydrochloride |
2,3 DCPE displays anticancer agent properties and induces ERK activation.
|
A15331 |
C 75 |
C 75 is an inhibitor of fatty acid synthase (FAS) reducing food intake and body weight in mice.
|
A15332 |
CHM 1 |
CHM 1 is a potent, selective antitumor agent in human hepatocellular carcinoma in vitro.
|
A15333 |
Oncrasin 1 |
Oncrasin 1 is a proapoptotic substance. Induces abnormal nuclear aggregation of PKC?? and suppressing RNA transcription.
|
A15334 |
Plumbagin |
Plumbagin, exhibits cytotoxicity in rodent models of carcinogenesis and carcinoma; has antifungal, antiviral, and antibacterial action.
|
A15335 |
Bax channel blocker |
Bax channel blocker is a potent inhibitor of Bax-mediated mitochondrial cytochrome C release (IC50 = 0.52 μM).
|
A15336 |
Bax inhibitor peptide P5 |
Bax inhibitor peptide P5, cell-permeable synthetic peptide inhibitor of Bax translocation to mitochondria; designed from Ku70, a protein that is suggested to suppress the mitochondrial translocation of Bax. Inhibits Bax-mediated apoptosis in vitro.
|
A15338 |
Bax inhibitor peptide, negative control |
Bax inhibitor peptide, negative control, negative control peptide for the Bax inhibitor peptides V5 and P5 , which inhibit Bax translocation to mitochondria and Bax-mediated apoptosis in vitro.
|
A15339 |
iMAC2 |
iMAC2 inhibits mitochondrial apoptosis-induced channel (MAC) (IC50 = 28 nM).
|
A15340 |
Muristerone A |
Muristerone A is a phytoecdysteroid analog of ecdysone which induces genes in mammalian cells and causes apoptosis in cells transfected with wild-type Bax.
|
A15342 |
DAPK Substrate Peptide |
DAPK Substrate Peptide, synthetic peptide substrate for death associated protein kinase (DAPK) (Km = 9 uM).
|
A15343 |
GRI 977143 |
GRI 977143, selective lysophosphatidic acid 2 (LPA2) receptor non-lipid agonist (EC50 = 3.3 uM).
|
A15345 |
TLQP 21 |
TLQP 21, VGF-derived peptide; spans residues 556-576 of the precursor sequence.
|
A15346 |
CP 31398 dihydrochloride |
CP 31398 dihydrochloride, p53 stabilizing agent. Stabilizes the active conformation of p53 and promotes p53 activity in cancer cell lines with mutant or wild-type p53. Inhibits growth of small human tumor xenografts in vivo.
|
A15347 |
HLI 373 |
HLI 373 is an inhibitor of Hdm2 ubiquitin ligase (E3) which blocks Hdm2-mediated ubiquitylation, proteasomal degradation of p53 and activates p53-dependent transcription.
|
A15348 |
MIRA-1 |
MIRA-1 restores wild-type conformation, function and DNA binding activity to mutant p53. Induces p53 transcriptional transactivation of p21, MDM2 and PUMA.
|
A15349 |
NSC 146109 hydrochloride |
NSC 146109 hydrochloride is a cell-permeable, genotype-selective antitumor agent that activates p53-dependent transcription.
|
A15350 |
PhiKan 083 |
PhiKan 083, p53 stabilizing agent; preferentially binds mutated (Y220C) p53 over wild-type p53 at a site distinct from functional DNA/protein interaction regions.
|
A15351 |
RETRA hydrochloride |
RETRA hydrochloride is an antitumor agent which inhibits tumor cell growth in a mutant p53- and p73-dependent manner in vitro and iin vivo.
|
A15352 |
SJ 172550 |
SJ 172550 is the first MDMX inhibitor with EC50 of 0.84 uM; binds reversibly to MDMX and effectively kills retinoblastoma cells in which the expression of MDMX is amplified.
|
A15353 |
WR 1065 |
WR 1065, a dephosphorylated metabolite of amifostine (Ethyol), can protect against the immediate and delayed effects of radiation exposure.
|
A15354 |
KD 5170 |
KD 5170, a novel mercaptoketone-based histone deacetylase inhibitor that exhibits broad spectrum antitumor activity in vitro and in vivo.
|
A15355 |
NCH 51 |
NCH 51 is a cell-permeable prodrug that is intracellularly converted to a potent HDAC inhibitor, with an IC50 of 48 nM.
|
A15356 |
NSC 3852 |
NSC 3852 is an HDAC (histone deacetylase) inhibitor.
|
A15357 |
TC-H 106 |
TC-H 106 is a slow, tight-binding inhibitor of class I HDACs (histone deacetylases).
|
A15358 |
Chetomin |
Chetomin is reported to be an antibiotic metabolite of Chaetomium spp. which contains bacteriostatic effects on Gram-positive bacteria.
|
A15359 |
KC7F2 |
KC7F2 is an inhibitor of HIF-1?? protein translation, but not transcription, that suppresses phosphorylation of two key regulators of protein synthesis, eukaryotic translation initiation factor 4E binding protein 1 (4EBP1) and p70 S6 kinase (S6K).
|
A15360 |
ML 228 |
ML-228 is an activator of the HIF signaling pathway, as demonstrated by HIF response element (HRE) reporter assay, HIF-1?? nuclear translocation assay, and increased VEGF expression.
|
A15361 |
1,2,3,4,5,6-Hexabromocyclohexane |
1,2,3,4,5,6-Hexabromocyclohexane is a potent and specific inhibitor of JAK2 autophosphorylation.
|
A15362 |
Cercosporamide |
Cercosporamide, an usnic amide, was originally identified in Cercosporidium henningsii as a host-selective phytotoxin and broad-spectrum antifungal agent and is a potent inhibitor of MAP-kinase interacting kinase-2 (Mnk2; IC50 = 11 nM), JAK3 (IC50 = 31), and Mnk1 (IC50 = 116 nM).
|
A15363 |
Cucurbitacin I |
Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells.
|
A15364 |
SD 1008 |
SD 1008 is reported to be a JAK2/STAT3 signaling pathway inhibitor which additionally inhibits Src. SD 1008 is noted to induce apoptosis in cell lines that express constitutively active tyrosine-phosphorylated STAT3.
|
A15365 |
TCS 21311 |
TCS 21311 is a potent JAK3 inhibitor (IC50 = 8 nM). TCS 21311 is selective for JAK3 over JAK1, JAK2 and Tyk 2 (IC50 values are 1017, 2550 and 8055 nM respectively).
|
A15366 |
ZM 449829 |
JAK3 Inhibitor V is a potent, selective inhibitor of JAK3 (Janus tyrosine kinase 3) which binds competitively to the JAK3 ATP site.
|
A15367 |
UNC 926 hydrochloride |
UNC 926 is a methyl lysine reader domain inhibitor.
|
A15368 |
PIM-1 Inhibitor 2 |
PIM-1 inhibitor 2 is a potent Pim-1 kinase inhibitor (Ki = 91 nM).
|
A15370 |
4-HQN |
4-HQN has been shown to inhibit PARP (poly(ADP-ribose) synthetase) which catalyzes covalent attachment of the ADP-ribose moiety of NAD+ to various proteins.
|
A15371 |
BYK 204165 |
BYK204165 is a cell-permeable isoquinolinedione compound that potently and selectively inhibits poly (ADP-ribose) polymerase 1 (PARP1).
|
A15372 |
BYK 49187 |
BYK 49187, PARP-1 and PARP-2 inhibitor (pIC50 values are 8.36 and 7.50 for cell-free recombinant PARP-1 and murine PARP-2 respectively).
|
A15373 |
DR 2313 |
PARP Inhibitor XIDR 2313, PARP Inhibitor XI, is a water soluble pyrimidinone compound that functions as a PARP (Poly(ADP-ribose) polymerase) inhibitor.
|
A15374 |
EB 47 |
EB 47 is a potent inhibitor of PARP1 with IC50 of 45 nM.
|
A15375 |
NU 1025 |
NU 1025 is a potent poly(ADP-ribose) polymerase (PARP) inhibitor, which potentiates the cytotoxicity of a panel of mechanistically diverse anti-cancer agents in L1210 cells.
|
A15376 |
Calcineurin Autoinhibitory Peptide |
Calcineurin inhibitory peptide is a selective inhibitor of Ca2+-calmodulin-dependent protein phosphatase (calcineurin) (IC50 ~ 10 uM). Does not inhibit PP1, PP2A or CaM kinase II (IC50 > 100 mM).
|
A15377 |
Ceramide |
Ceramide is a ceramide shown to be a potent modulator of proliferation and differentiation, used as a tool for studying the complex signaling associated with the ceramides.
|
A15378 |
DL-AP3 |
DL-AP3, a racemic preparation of D-AP3 and L-AP3, is an inhibitor of phosphoserine phosphatase and an antagonist of the metabotropic glutamate receptor (mGluR), blocking phosphoinositide turnover mediated by the mGluR.
|
A15379 |
Fumonisin B1 |
Fumonisin B1 is a fungal metabolite produced by Fusarium moniliforme, that has been shown to inhibit protein serine/threonine phosphatases (PP1, PP2A, PP2B, PP2C, and PP5/T/K/H), and is most effective with PP5.
|
A15380 |
INCA-6 |
INCA-6 is a potent and selective inhibitor of calcineurin-NFAT (Nuclear Factor of Activated T cells) signaling.
|
A15381 |
NFAT Inhibitor |
NFAT Inhibitor, selective inhibitor of calcineurin-mediated dephosphorylation of nuclear factor of activated T cells (NFAT).
|
A15382 |
Alexidine dihydrochloride |
Alexidine is an alkyl bis(biguanide) antiseptic which has been used in mouthwashes to eliminate plaque forming microorganisms.
|
A15383 |
BVT 948 |
BVT 948 is a non-competitive PTP (protein tyrosine phosphatase) inhibitor.
|
A15384 |
NSC 87877 |
NSC 87877 is a potent inhibitor of shp2 and shp1 protein tyrosine phosphatases (SH-PTP2 and SH-PTP1).
|
A15385 |
Mithramycin A |
Mithramycin A is an antibiotic DNA/RNA polymerase and DNA binding transcriptional inhibitor observed to facilitate TNF-?? and Fas-ligand induced apoptosis.
|
A15386 |
Thiolutin |
Thiolutin is an RNA polymerase inhibitor, and a sulfur-based microbial antibiotic generated by Streptomyces sp.
|
A15387 |
TCS HDAC6 20b |
TCS HDAC6 20b, selective inhibitor of histone deacetylase 6 (HDAC6). Inhibits HCT116 growth in combination with taxol. Also inhibits growth of MCF-7 cells stimulated by estrogen.
|
A15388 |
UNC 0224 |
UNC0224 is a potent and selective G9a inhibitor with IC50 of 15 nM in in the G9a Thioglo assay.
|
A15389 |
NSC 33994 |
NSC 33994 is novel inhibitor of JAK2 tyrosine kinase (Janus kinase 2 ). Janus kinase 2 (JAK2) plays a crucial role in the pathomechanism of myeloproliferative disorders and hematological malignancies.
|
A15390 |
TCS 401 |
TCS 401 is a selective inhibitor of protein-tyrosine phosphatase 1B (PTP1B) (Ki values are 0.29, 59, 560, 1100, > 2000, > 2000 and > 2000 μM for PTP1B, CD45 D1D2, PTPβ, PTPε D1, SHP-1, PTPα D1 and LAR D1D2 respectively).
|
A15392 |
Boc-D-FMK |
BOC-D-FMK is a Novel inhibitor of Caspase-3.
|
A15393 |
Ophiopogonin D' |
Ophiopogonin D', extracted from Ophiopogon japonicus (Thunb.) Ker-Gawl. dried tuberous roots.
|
A15394 |
Mogroside IVe |
Mogroside Ive, Extracted from Siraitia grosvenorii (Swingle) C. Jeffrey ex Lu et Z. Y. Zhang dried fruit .
|
A15395 |
Diosmetin-7-O-beta-D-glucopyranoside |
Diosmetin-7-O-beta-D-glucopyranoside, extracted from Chrysanthemum dried flowers.
|
A15396 |
Quercetin-7-O-beta-D-glucopyranoside |
Quercetin-7-O-beta-D-glucopyranoside, extracted from Sophora flavescens Ait.
|
A15397 |
Isorhamnetin 3-O-beta-D-Glucoside |
Isorhamnetin-3-O-beta-D-Glucoside, extracted from dried whole herb of Filifolium Kitam. Filifolium sibiricum (L.) Kitam..
|
A15398 |
CiMigenol 3-beta-D-xylopyranoside |
CiMigenol 3-beta-D-xylopyranoside, extracted from Beesia calthifolia( Maxim. ) Ulhr. Rhizome.
|
A15399 |
alpha-hederin |
Alpha-hederin, a saponin extracted from Hedera helix.
|
A15400 |
alpha-Boswellic acid |
alpha-Boswellic acid, extracted from Boswellia sacra.
|
A15401 |
Rhein-8-O-beta-D-glucopyranoside |
Rhein-8-O-beta-D-glucopyranoside, extracted from Rheum palmatum L. rhizome.
|
A15402 |
Chrysophanol-8-O-beta-D-glucopyranoside |
Chrysophanol-8-O-beta-D-glucopyranoside, extracted from Rheum palmatum L?? rhizome.
|
A15403 |
N-Methylcytisine |
N-methylcytisine, a selective ligand of nicotinic receptors of acetylcholine in the CNS.
|
A15404 |
Apigenin-7-O-beta-D-glucopyranoside |
Apigenin-7-O-beta-D-glucopyranoside, extracted from Andrographis paniculata Nees. dried parts on the ground.
|
A15405 |
Cucurbitacin IIb |
Cucurbitacin Iib, extracted from Hemsleya amabilis Diels root tuber.
|
A15406 |
Cucurbitacin S |
Cucurbitacin S, extracted from Hemsleya amabilis Diels root tuber.
|
A15407 |
Cimigenol-3-O-alpha-L-arabinoside |
Cimigenol-3-O-alpha-L-arabinoside is extracted from Cimicifuga foetida L. dried rhizome.
|
A15408 |
20(R)-Ginsenoside Rh2 |
20(R)-Ginsenoside Rh2 is a matrix metalloproteinase (MMP) inhibitor that acts as a cell antiproliferator.
|
A15409 |
2''-O-Galloylhyperin |
2''-O-Galloylhyperin, extracted from whole dried herb of pyrola wintergreen and Pyrola decorata H.Andres.
|
A15410 |
Magnoflorine iodide |
Magnoflorine iodide is extracted from Thalictrum dasycarpum Fisch.et Hall.
|
A15412 |
beta-Eudesmol |
beta-Eudesmol is extracted from eucalyptus oil.
|
A15413 |
alpha-Cyperone |
alpha-Cyperone is extracted from Cyperus rotundus L. dried rhizome.
|
A15414 |
Amyloid b-peptide (42-1) (human) |
Amyloid b-peptide (42-1) (human), inactive control for Amyloid b (1-42) peptide.
|
A15415 |
Amyloid b-Peptide (10-20) (human) |
Amyloid b-Peptide (10-20) (human), soluble amyloid b-peptide fragment that is a substrate for gelatinase A/type IV collagenase/MMP-2 and APP secretase; cleaved between Lys16 and Leu17.
|
A15417 |
Amyloid b-Peptide (12-28) (human) |
Amyloid b-Peptide (12-28) (human), amyloid b-peptide fragment; minimum section required to bind to brain proteins.
|
A15418 |
Amyloid b-Peptide (1-40) (human) |
Amyloid b-Peptide (1-40) (human) is a peptide processed from the amyloid precursor protein (APP).
|
A15419 |
Amyloid b-peptide (1-40) (rat) |
Amyloid b-peptide (1-40) (rat)
|
A15420 |
Amyloid b-peptide (1-42) (rat) |
Amyloid b-peptide (1-42) (rat)
|
A15421 |
Amyloid b-Peptide (1-43) (human) |
Amyloid b-Peptide (1-43) (human), amyloid β peptide fragment. Highly toxic, showing higher neurotoxicity compared to Aβ40 and Aβ42.
|
A15422 |
beta-Pompilidotoxin |
beta-Pompilidotoxin is a peptide with the sequence H2N-Arg.
|
A15423 |
beta-Amyloid (1-11) |
Beta-amyloid (1-11) (Abeta) is a peptide with the sequence H-{Asp}{Ala}{Glu}{Phe}{Arg}{His}{Asp}{Ser}{Gly}{Tyr}{Glu}-OH,which is processed from the Amyloid precursor protein.
|
A15424 |
Amyloid b-Protein (1-15) |
Beta-amyloid protein (A beta), a 39-43 amino acid peptide composed of a portion of the transmembrane domain and the extracellular domain of the amyloid precursor protein (APP), is also the principal component of amyloid.
|
A15425 |
Beta-Lipotropin (1-10), porcine |
Beta-lipotropin (beta-LPH) was found to contain within its C-terminal sequence the primary structure of these peptides.
|
A15426 |
beta-Interleukin I (163-171), human |
beta-Interleukin I (163-171), human, a peptide. Interleukins are a group of cytokines (secreted proteins/signaling molecules) that were first seen to be expressed by white blood cells (leukocytes).
|
A15427 |
Clasto-Lactacystin b-lactone |
Clasto-lactacystin b-lactone was later identified as the active metabolite of lactacystin, resulting from the elimination of cysteine and the formation of a reactive b-lactone.
|
A15428 |
Zidovudine |
Zidovudine is a nucleoside analog reverse-transcriptase inhibitor (NRTI), a type of antiretroviral drug used for the treatment of HIV/AIDS infection. Azidothymidine decreases CRISPR-mediated homology directed repair (HDR) efficiency.
|
A15429 |
6b-Hydroxy-21-desacetyl Deflazacort |
N/A
|
A15430 |
PI4KIII beta inhibitor 3 |
PI4KIII beta inhibitor 3 is a novel and high effective PI4KIII beta inhibitor with IC50 of 5.7 nM.
|
A14351 |
Isatoribine |
Isatoribine is a novel guanosine analogue showing immunostimulatory activity both in vivo and in vitro.
|
A14987 |
ALK inhibitor 1 |
ALK inhibitor 1 is a novel and selective inhibitor for the ALK kinase.
|
A14988 |
ALK inhibitor 2 |
ALK inhibitor 2 is a novel and selective inhibitor for the ALK kinase.
|
A14989 |
Alosetron Hydrochloride |
Alosetron is s Serotonin 5HT3-receptor antagonist that is used in treatment of irritable bowel syndrome.
|
A14990 |
Alvespimycin |
Alvespimycin is a selective Hsp90 inhibitor with a GI50 of 53 nM.
|
A14991 |
Alvimopan dihydrate |
Alvimopan dihydrate(LY 246736, ADL 8-2698) is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
|
A14992 |
Alvimopan monohydrate |
Alvimopan monohydrate is a peripherally acting mu-opioid receptor (PAM-OR, IC50= 1.7 nM) antagonist for accelerating gastrointestinal recovery after surgery.
|
A14994 |
AM679 |
AM679 is a potent and selective FLAP inhibitor with IC50s of 2.2 nM/0.6 nM/154 nM for FLAP binding/hLA/hWB respectively.
|
A14995 |
Amadacycline |
Amadacycline is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
|
A14996 |
Amadacycline methanesulfonate |
Amadacycline methanesulfonate is a new tetracycline antibiotic in the pipeline, which can inhibit the 30s subunit of bacterial ribosome.
|
A14997 |
AMD-070 HCl |
AMD-070 hydrochloride is a potent and selective antagonist of CXCR4 with an IC50 value of 13 nM in a CXCR4 125I-SDF inhibition binding assay, inhibit the replication of T-tropic HIV-1 (NL4.3 strain) in MT-4 cells and PBMCs.
|
A14998 |
Amineptine |
Amineptine is a tricyclic antidepressant drug selectively blocking dopamine uptake, on 3H-imipramine binding, which was investigated in platelets of major depressed patients in conjunction with changes in clinical state.
|
A14999 |
AN-2690 |
AN-2690, an antifungal agent with activity against Trichophyton species, in a topical solution formulation, for the potential treatment of onychomycosis.
|
A15000 |
Anamorelin Fumarate |
Anamorelin fumarate is a synthetic orally active ghrelin receptor agonist which is under development for the management of non-small lung cancer associated cachexia/anorexia.
|
A15001 |
ARRY-520 R enantiomer |
ARRY-520 R enantiomer is the R form of ARRY-520, which is a synthetic, small molecule kinesin spindle protein (KSP) inhibitor with IC50 of 6 nM.
|
A15002 |
Asenapine HCl |
Asenapine hydrochloride inhibits adrenergic receptor (α1, α2A, α2B, α2C) with Ki of 0.25-1.2 nM and also inhibits 5-HT receptor (1A, 1B, 2A, 2B, 2C, 5A, 6, 7) with Ki of 0.03-4.0 nM.
|
A15003 |
AST 487 |
AST487 is a Ret kinase inhibitor/FLT3 inhibitor with IC50 of 0.88 uM for Ret.
|
A15004 |
AT-101 |
AT101, the R-(-) enantiomer of Gossypol acetic acid, binds with Bcl-2, Bcl-xL and Mcl-1 with Ki of 0.32μM, 0.48μM and 0.18μM.
|
A15005 |
AT7519 trifluoroacetate |
AT7519 trifluoroacetate is a multi-CDK inhibitor for CDK1, 2, 4, 6 and 9 with IC50 of 10-210 nM, less potent to CDK3 and little active to CDK7.
|
A15006 |
AT7867 2HCl |
AT7867 dihydrochloride is a potent ATP-competitive inhibitor of Akt1/2/3 and p70S6K/PKA with IC50 of 32 nM/17 nM/47 nM and 85 nM/20 nM, respectively, little activity outside the AGC kinase family.
|
A15007 |
Atrasentan HCl |
Atrasentan hydrochloride is an endothelin antagonist receptor (IC50=0.0551 nM, ETA) being developed for the treatment of prostate cancer.
|
A15008 |
AVL-292 benzenesulfonate |
AVL-292 benzenesulfonate is a covalent, highly selective, orally active small molecule inhibitor of Btk with IC50 value of 0.5 nM, >1400-fold selectivity over the other kinases assayed.
|
A15009 |
Azaphen dihydrochloride monohydrate |
Azaphen is a potent inhibitor of the reuptake of serotonin.
|
A15010 |
Azathramycin |
Azithromycin, derived from erythromycin, is a antibiotic. Azithromycin binds to the 50S subunit of the bacterial ribosome, and thus inhibits translation of mRNA.
|
A15011 |
AZD1152 |
AZD1152 is a pro-drug that rapidly undergoes phosphatase-mediated cleavage in serum to release barasertib-hQPA, a selective Aurora B kinase inhibitor that has shown preliminary activity in clinical studies of patients with acute myeloid leukemia (AML).
|
A15012 |
AZD7687 |
AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1).
|
A15014 |
Baricitinib phosphate |
Baricitinib phosphate is a selective JAK1 and JAK2 inhibitor with IC50 of 5.9 nM and 5.7 nM, ~70 and ~10-fold selective versus JAK3 and Tyk2, no inhibition to c-Met and Chk2.
|
A15015 |
Bavisant dihydrochloride |
Bavisant dihydrochloride is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
|
A15016 |
Bavisant dihydrochloride hydrate |
Bavisant dihydrochloride hydrate is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD.
|
A12730 |
Epoxomicin |
Epoxomicin is a potent anti-tumor agent isolated from Actinomycetes that is used as a selective and irreversible inhibitor of the 20S proteasome.
|
A12881 |
BX-517 |
BX-517 is a potent and selective inhibitor of PDK1 that binds to the ATP binding pocket of the protein (IC50 = 6 nM).
|
A12947 |
UNC0638 |
UNC0638 is an inhibitor of protein lysine methyltransferases G9a(IC50<15 nM) and GLP(IC50=19 nM) with excellent potency and selectivity over a wide range of epigenetic and non-epigenetic targets.
|
A12998 |
Laninamivir (CS-8958) |
Laninamivir is a neuraminidase inhibitor which is being researched for the treatment and prophylaxis of Influenzavirus A and Influenzavirus B.
|
A13029 |
Radotinib (IY-5511) |
Radotinib is a novel and selective Bcl-Abl tyrosine kinase inhibitor
|
A15556 |
ML204 |
ML204 is a novel potent antagonist that selectively modulates native TRPC4/C5 ion channels.
|
A15760 |
SU10944 |
SU10944 is a small molecule kinase inhibitor of VEGFR that inhibits neovascularization and permeability, and is distributed to the eye upon systemic delivery.
|
A15762 |
BI-847325 |
BI-847325 is an orally bioavailable, and selective dual MEK/Aurora kinase inhibitor with IC50 of 3 nM, 25 nM, 15 nM, 25 nM, and 4 nM for Xenopus laevis Aurora B, human Aurora A and Aurora C, as well as human MEK1 and MEK2, respectively. Phase 1.
|
A15766 |
Mc-Val-Cit-PABC-PNP |
Mc-Val-Cit-PABC-PNP is a cathepsin cleavable ADC peptide linker.
|
A15767 |
NU2058 |
NU2058 is a guanine-based CDK inhibitor with IC50 of 17 uM and 26 uM for CDK2 and CDK1.
|
A15769 |
SBC-115076 |
SBC-115076 is an anti-proprotein convertase subtilisin kexin type 9 (anti-PCSK9) compounds, for the treatment and/or prevention of cardiovascular diseases.
|
A15771 |
Oritavancin (LY333328) |
Oritavancin is a novel semisynthetic glycopeptide antibiotics. On August 6, 2014, the FDA approved oritavancin for treatment of skin infections. Oritavancin possesses potent and rapid bactericidal activity in vitro against a broad spectrum of both resistant and susceptible Gram-positive bacteria, including Staphylococcus aureus, MRSA, enterococci, and streptococci.
|
A15772 |
GS-7340 |
GS-7340 is a prodrug of tenofovir (TFV) that more efficiently delivers TFV into lymphoid cells and tissues than TFV disoproxil fumarate.
|
A15773 |
Cardiogenol C hydrochloride |
Cardiogenol C hydrochloride is a potent and cell permeable inducer of embryonic stem cell differentiation in cardiomyocytes displaying an Ec50 of 100nm.
|
A15774 |
ISX-9 |
ISX-9 is a small molecule inducer of adult neural stem cell differentiation.
|
A15775 |
NIBR189 |
NIBR189 is a small molecule antagonist of the Epstein-Barr virus-induced gene 2 (EBI2; GPR183) receptor with IC50 of 16 nM(Binding) and 11 nM (Functional).
|
A15777 |
JH-II-127 |
JH-II-127 is a highly potent, selective, and brain penetrant LRRK2 inhibitor, with IC50 of 6.6 nM, 2.2 nM ,47.7 nM for LRRK2-wild-type, LRRK2-G2019S, LRRK2-A2016T.
|
A15778 |
Mavatrep |
Mavatrep is an orally bioavailable TRPV1 antagonist (Ki=6.5 nM), exhibits minimal effect on the enzymatic activity (IC50 > 25 μM) of CYP isoforms 3A4, 1A2, and 2D6.
|
A15779 |
CC-115 |
CC-115 is a inhibitor of mTOR/DNA-PK (IC50= 21/ 13 nM).
|
A15781 |
UF010 |
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 uM, 0.1 uM, 0.5 uM and 1.5 uM for HDACs 3, 2, 1 and 8, respectively. It has > 6-fold selectivity over other HDACs.
|
A15782 |
Acotiamide hydrochloride trihydrate |
Acotiamide is a drug approved in Japan for the treatment of postprandial fullness, upper abdominal bloating, and early satiation due to functional dyspepsia.
|
A15783 |
Isavuconazole |
Isavuconazole is the active component of the new azole antifungal agent BAL8557, exhibits MIC(50)s/MIC(90)s ranged from 0.002/0.004 mg/liter for C. albicans to 0.25/0.5 mg/liter for C. glabrata.
|
A15784 |
OPC21268 |
OPC21268 is a non-peptide AVP Receptor V (Vasopressin Receptor) antagonist that shows 1000-fold selectivity for V1 receptors over V2 receptors.
|
A15785 |
7ACC2 |
7ACC2 is a new potent MCT inhibitor with IC50 of 11 nM for inhibition of [14C]-lactate influx; new antitumor treatment targeting lactate transport in cancer cells.
|
A15786 |
NVP-TNKS656 |
NVP-TNKS656 is a highly potent, selective, and orally active TNKS2 inhibitor with IC50 of 6 nM; > 300 fold selectivity against PARP1 and PARP2.
|
A15787 |
Propyzamide |
Propyzamide is usually used as a selective herbicide.
|
A15788 |
Ascomycin (FK520) |
Ascomycin is an ethyl analog of tacrolimus (FK506) with strong immunosuppressant properties. It has been researched for the treatment of autoimmune diseases and skin diseases, and to prevent rejection after an organ transplant.
|
A15770 |
Ursodeoxycholic acid |
Ursodeoxycholic acid (UDCS) is a cell protectant used extensively to mitigate hepatic and biliary diseases.
|
A15790 |
L189 |
L189 is a novel human DNA ligase inhibitor, inhibits hLigI/III/IV with IC50 of 5/9/5 μM.
|
A15791 |
CGS19755 |
CGS 19755 (cis-4-phosphonomethyl-2-piperidine carboxylic acid) was found to be a potent, stereospecific inhibitor of N-methyl-D-aspartate (NMDA)-evoked, but not KCl-evoked, [3H] acetylcholine release from slices of the rat striatum.
|
A15792 |
BMS-817378 |
BMS-817378 is a novel prodrug of the dual Met/VEGFR-2 inhibitor BMS-794833.
|
A15793 |
JNJ-42041935 |
JNJ-42041935 is a potent (pKi = 7.3-7.9), 2-oxoglutarate competitive, reversible, and selective inhibitor of PHD enzymes.
|
A15796 |
L-778123 HCl |
L-778123 HCl is an inhibitor of FPTase and GGPTase-I with IC50 of 2 nM and 98 nM in enzyme inhibition determination.
|
A15798 |
SW033291 |
SW033291 is a small-molecule inhibitor of 15-PGDH (Ki=0.1 nM) that increases prostaglandin PGE2 levels in bone marrow and other tissues.
|
A15800 |
SM-164 |
SM-164 is a potent cell-permeable and bivalent Smac mimetic which bind to a XIAP protein with a Ki value of 0.56 nM, and binds to cIAP-1 and cIAP-2 proteins with Ki values of 0.31 and 1.1 nM, respectively.
|
A12584 |
ON123300 |
ON123300 is a potent multikinase inhibitor and may be potential useful for brain tumor chemotherapy. ON123300 strongly inhibits Ark5 and CDK4, as well as growth factor receptor tyrosine kinases such as ??-type platelet-derived growth factor receptor (PDGFR??).
|
A12585 |
MS023 |
MS023 is a potent inihbitor of PRMTs 1,3,4,6,and 8 (IC50 = 30, 119, 83, 8, and 8 nM, respectively), which are responsible for asymmetric dimethylation of arginine residues.
|
A11538 |
Pardoprunox HCl (SLV-308) |
Pardoprunox is an antiparkinsonian drug currently under development by Solvay for the treatment of Parkinson's disease.
|
A12194 |
AL082D06 |
AL082D06 is a nonsteroidal glucocorticoid receptor antagonist.
|
A12386 |
Eliglustat |
Eliglustat is a specific and potent inhibitor of glucosylceramide synthase.
|
A12390 |
JZL195 |
JZL195 is a selective and efficacious dual FAAH/MAGL inhibitor with IC50 of 13 nM and 19 nM for mouse brain FAAH and MAGL respectively.
|
A12405 |
NS6180 |
NS6180 is a novel potent and selective KCa3.1 channel inhibitor(IC50= 9 nM) prevents T-cell activation and inflammation.
|
A12595 |
BIO-32546 |
BIO-32546 is a novel modulator of the activity of the autotaxin (ATX) enzyme
|
A12937 |
(R)-P7C3-Ome |
(R)-P7C3-Ome is a methoxy derivative of parent compound P7C3, an aminopropyl carbazole that exhibits antidepressant and neuroprotective activities.
|
A12946 |
Eliprodil |
Eliprodil is a non-competitive NR2B-NMDA receptor antagonist(IC50=1 uM), less potent for NR2A- and NR2C-containing receptors(IC50> 100 uM).
|
A13196 |
BD-1047 2HBr |
BD-1047 2HBr is a selective functional antagonist of sigma receptors, shows antipsychotic activity in animal models predictive of efficacy in schizophrenia.
|
A13199 |
Trovirdine |
Trovirdine inhibits HIV-1 RT with an IC50 of 7 nM when employing heteropolymeric primer/template (oligo-DNA/ribosomal RNA)and dGTP as substrate.
|
A13216 |
RO462005 |
RO462005 is an endothelin receptor selective agonist.
|
A13405 |
HDAC inhibitor |
N/A
|
A16069 |
Versipelostatin |
Versipelostatin is a novel GRP78/Bip molecular chaperone down-regulator of microbial origin that was isolated from the metabolite of Streptomyces versipellis strain 4083-SVS6.
|