New Products

Catalog No. Product Name Application Information
A19021
AMG-510 (Sotorasib)
KRAS G12C covalent inhibitor
AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.
A18712
MD-224
MDM2 degrader
MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.
A17228
MDL-800
SIRT6 allosteric activator
MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.
A17244
Fevipiprant
CRTh2 receptor antagonist
Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment.
A17223
MRTX1257
KRAS-G12C inhibitor
MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.
A17231
NUN82647
G2 phase inhibitor, apoptosis inducer
NUN82647, also known as QBS or 2-Amino-N-quinolin-8-yl-benzenesulfonamide, is an Inhibitor of cell cycle at G2 phase; apoptosis inducer.
A17230
BIBF0775
TGFβRI 抑制剂
BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI).
A17221
PF-06371900
LRRK2 inhibitor
PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor.
A17240
Incyclinide
MMP inhibitor
Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.
A17233
BUN60856
cFMS Receptor Inhibitor
BUN60856, also known as cFMS Receptor Inhibitor II, is a cFMS inhibitor.
A17216
BAY-876
GLUT1 抑制剂
BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in?vitro and high oral bioavailability in?vivo.
A17217
Pelitrexol (AG-2037)
GARFT inhibitor
Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity.
A17226
Mivebresib (ABBV-075)
BET inhibitor
Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity.
A17236
DC661
PPT1 inhibitor
DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).
A17241
Autophinib
Autophagy inhibitor
Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.
A17220
NPI64
Protease inhibitor
NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease.
A17225
AZ304
dual BRAF 抑制剂
AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.
A17242
PSMA617 TFA
PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.
A17227
AG1295
PDGFR 抑制剂
AG1295 is a PDGF receptor specific inhibitor.
A17222
Ras-IN-3144
pan-RAS inhibitor
Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.
A17229
KC01
ABHD16A inhibitor
KC01 is a covalent inhibitor of ABHD16A.
A17218
MX1013
pan-caspase inhibitor
MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9.
A17232
PUN30119
PUN30119, also known as Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.
A17239
CCT245737
CHK1 inhibitor
CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.
A17235
SBI-115
GPCR19 antagonist
SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.
A17245
Firocoxib
COX-2 抑制剂
Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses.
A17234
KL1333
NAD+ Modulator
KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.
A17219
MLS0315771
MPI inhibitor
MLS0315771 is a potent competitive phosphomannose isomerase (MPI) inhibitor.
A17243
SNJ-1945
Calpain inhibitor
SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly.
A17238
Ro 08-2750
NGF inhibitor
Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).
A17237
SAR-7334 HCl
TRPC6 inhibitor
SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.
A17224
Sulfabromomethazine
Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.
A17146
AG-126
ERK2 抑制剂
AG-126是一种ERK2抑制剂,它在25-50μM下选择性抑制ERK1(p44)和ERK2(p42)的磷酸化。
A17157
SMI-16a
Pim kinase 抑制剂
SMI-16a是选择性的Pim激酶抑制剂,其对Pim1,Pim2和PC3细胞的IC 50值分别为0.15、0.02和48μM。
A17117
SKA-31
potassium channel activator
SKA-31是KCa2和KCa3.1钙激活钾通道的激活剂。
A17155
KIN-1148
IRF3 激动剂
KIN-1148是一种小分子IRF3激动剂,可通过调节抗病毒免疫反应来充当流感疫苗佐剂。
A17122
COH000
SUMO E1 抑制剂
COH000是高度特异性的共价变构SUMO E1抑制剂,其IC50为0.2μM,用于体外SUMO化。
A17118
TR-14035
Integrin 拮抗剂
TR-14035是α4β7和α4β1整联蛋白的双重拮抗剂。
A17125
CZC-25146
LRRK2 抑制剂
CZC-25146是有效的LRRK2抑制剂。
A17154
SU-5408
VEGFR2 Kinase 抑制剂
SU-5408,也称为VEGFR2激酶抑制剂I,是一种有效的,细胞渗透性的小鼠VEGFR2激酶抑制剂,IC50值为70 nM。
A17127
YHO-13177
BCRP/ABCG2 抑制剂
YHO-13177是一种有效且特异性的乳腺癌抗性蛋白(BCRP/ABCG2)抑制剂。
A17134
XMD8-87
TNK2 抑制剂
XMD8-87是酪氨酸激酶非受体2(TNK2)抑制剂,IC50值为1.9μM。
A17129
BIO
GSK3 抑制剂
BIO是一种细胞可渗透的双吲哚(靛玉红)化合物,可作为GSK3α/β的强效,选择性,可逆和ATP竞争性抑制剂。IC50值为5 nM。
A17126
FX1
BCL6 抑制剂
FX1是转录因子B细胞淋巴瘤6(BCL6)的抑制剂,IC50值为?35μM。
A17014
MZ1
BRD4 protein degrader
MZ1是BRD2和BRD3上BRD4可逆,持久和选择性去除的有效诱导剂。
A17065
BCI-121
SMYD3 抑制剂
BCI-121是SMYD3抑制剂。它通过削弱癌细胞的生长来发挥作用。
A17159
TRC051384
Hsp70 inducer
TRC051384是热休克蛋白Hsp70的诱导剂。
A17162
ISCK03
c-kit 抑制剂
ISCK03是有效的c-kit抑制剂。
A17142
AG-494
EGFR 抑制剂
AG-494是表皮生长因子受体激酶的抑制剂,在HT-22细胞中的IC50值为1μM。
A17153
SU 5205
VEGFR2 抑制剂
SU 5205是VEGFR2抑制剂, IC50 = 9.6 ?M。
A17136
TCS-OX2-29 HCl
OX2 receptor 拮抗剂
TCS-OX2-29 HCl是一种选择性OX2受体拮抗剂,IC50值为40 nM。
A17130
XMD16-5
TNK2 抑制剂
XMD16-5是酪氨酸激酶非受体2(TNK2)抑制剂。

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