AMG-510 is a potent, orally bioavailable, and selective KRAS G12C covalent inhibitor with anti-tumor activity.

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.

MDL-800 is a first-in-class cellularly active SIRT6 allosteric activator.

Fevipiprant, also known as NVP-QAW039 or QAW039, is an oral active and potent CRTh2 receptor antagonist and potentially useful for asthma treatment.

MRTX1257 is a potent, selective, covalent and irreversible inhibitor of KRAS G12C, MRTX1257 inhibited KRAS dependent ERKphosphorylation in the H358cell assay with an IC50= 900 pM.

NUN82647, also known as QBS or 2-Amino-N-quinolin-8-yl-benzenesulfonamide, is an Inhibitor of cell cycle at G2 phase; apoptosis inducer.

BIBF0775 is an inhibitor of the transforming growth factor β receptor I (TGFβRI).

PF-06371900 is a potent and highly selective leucine rich repeat kinase 2 (LRRK2) inhibitor.

Iincyclinide, also known as CMT-3 and COL-3, is a MMP inhibitor and a chemically-modified tetracycline with potential antineoplastic activity. Incyclinide inhibits matrix metalloproteinases (MMPs), thereby inducing extracellular matrix degradation, and inhibiting angiogenesis, tumor growth and invasion, and metastasis. This agent also causes mitochondrial depolarization in tumor cells and induces both cellular apoptosis and tissue necrosis.

BUN60856, also known as cFMS Receptor Inhibitor II, is a cFMS inhibitor.

BAY-876 is a potent and Selective GLUT1 Inhibitor. BAY-876 showed good metabolic stability in?vitro and high oral bioavailability in?vivo.

Pelitrexol is a GARFT inhibitor, and is also a water soluble antifolate with anti-proliferative activity.

Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity.

DC661 is a potent palmitoyl-protein thioesterase 1 (PPT1) inhibitor. DC661 inhibits autophagy. DC661 is capable of deacidifying the lysosome and inhibiting autophagy significantly better than hydroxychloroquine (HCQ).

Autophinib is a novel potent autophagy inhibitor, inhibiting autophagy induced by starvation or Rapamycin by targeting the lipid kinase VPS34.

NPI64 is a broad-spectrum coronavirus protease inhibitor which inhibits viral 3C and 3C-like protease.

AZ304 is a potent dual BRAF inhibitor targeting the kinase domains of wild type BRAF, V600E mutant BRAF. AZ304 exerted potent inhibitory effects on both wild type and V600E mutant forms of the serine/threonine-protein kinase BRAF, with IC50 values of 79?nM and 38?nM, respectively.

PSMA-617, also know as vipivotide tetraxetan. It is a ligand used to make 177Lu-PSMA-617, which is a radioactive molecule to fight cancer.

AG1295 is a PDGF receptor specific inhibitor.

Ras-IN-3144 is a pan-RAS inhibitor which inhibits RAS signaling pathways in cancer cells and prevents the growth of RAS mutant mouse cancer xenografts.

KC01 is a covalent inhibitor of ABHD16A.

MX1013 is a dipeptide pan-caspase inhibitor that inhibits caspase-1, caspase-3, and caspase-6, 7, 8, and 9.

PUN30119, also known as Imidazole ketone erastin (IKE), is a potent, metabolically stable inhibitor of system xc- and inducer of ferroptosis potentially suitable for in vivo applications.

CCT245737 is a potent, selective and orally active checkpoint kinase 1 (CHK1) inhibitor. CCT245737 showed CHK1 IC50 = 1.3 nM, CHK2 IC50 = 2440 nM, G2 check point abrogation IC50 = 30 nM. Mouse F (oral)=100%.

SBI-115 is a TGR5 (GPCR19) antagonist. SBI-115 decreases hepatic cystogenesis with polycystic liver diseases via inhibiting TGR5.

Firocoxib is a non-steroidal anti-inflammatory drug of the COX-2 inhibitor class, currently approved for use in dogs and horses.

KL1333 is an orally available, small organic molecule that reacts with NAD(P)H:quinone oxidoreductase 1 (NQO1) as a substrate, resulting in increases in intracellular NAD+ levels via NADH oxidation. KL-1333 Improves Energy Metabolism and Mitochondrial Dysfunction in MELAS Fibroblasts.

MLS0315771 is a potent competitive phosphomannose isomerase (MPI) inhibitor.

SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly.

Ro 08-2750 is a potent and selective Nerve growth factor (NGF) inhibitor that binds the NGF dimer (KD ~ 1 μM).

SAR7334 is a novel, highly potent and bioavailable inhibitor of TRPC6 channels that opens new opportunities for the investigation of TRPC channel function in vivo. SAR7334 inhibited TRPC6, TRPC3 and TRPC7-mediated Ca(2+) influx into cells with IC50 s of 9.5, 282 and 226 nM, whereas TRPC4 and TRPC5-mediated Ca(2+) entry was not affected.

Sulfabromomethazine, also known as Bromosulfamethazine, NSC 5874, SN 3517, is a long-acting derivative of sulfamezathine that is used in the poultry, swine and cattle industries for the treatment of coccidiosis.

AG-126是一种ERK2抑制剂，它在25-50μM下选择性抑制ERK1（p44）和ERK2（p42）的磷酸化。

SMI-16a是选择性的Pim激酶抑制剂，其对Pim1，Pim2和PC3细胞的IC 50值分别为0.15、0.02和48μM。

SKA-31是KCa2和KCa3.1钙激活钾通道的激活剂。

KIN-1148是一种小分子IRF3激动剂，可通过调节抗病毒免疫反应来充当流感疫苗佐剂。

COH000是高度特异性的共价变构SUMO E1抑制剂，其IC50为0.2μM，用于体外SUMO化。

TR-14035是α4β7和α4β1整联蛋白的双重拮抗剂。

CZC-25146是有效的LRRK2抑制剂。

SU-5408，也称为VEGFR2激酶抑制剂I，是一种有效的，细胞渗透性的小鼠VEGFR2激酶抑制剂，IC50值为70 nM。

YHO-13177是一种有效且特异性的乳腺癌抗性蛋白（BCRP/ABCG2）抑制剂。

XMD8-87是酪氨酸激酶非受体2（TNK2）抑制剂，IC50值为1.9μM。

BIO是一种细胞可渗透的双吲哚（靛玉红）化合物，可作为GSK3α/β的强效，选择性，可逆和ATP竞争性抑制剂。IC50值为5 nM。

FX1是转录因子B细胞淋巴瘤6（BCL6）的抑制剂，IC50值为?35μM。

MZ1是BRD2和BRD3上BRD4可逆，持久和选择性去除的有效诱导剂。

BCI-121是SMYD3抑制剂。它通过削弱癌细胞的生长来发挥作用。

TRC051384是热休克蛋白Hsp70的诱导剂。

ISCK03是有效的c-kit抑制剂。

AG-494是表皮生长因子受体激酶的抑制剂，在HT-22细胞中的IC50值为1μM。

SU 5205是VEGFR2抑制剂， IC50 = 9.6 ?M。

TCS-OX2-29 HCl是一种选择性OX2受体拮抗剂，IC50值为40 nM。

XMD16-5是酪氨酸激酶非受体2（TNK2）抑制剂。