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搜索结果：“receptor”

“receptor”的搜索结果

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GW3965 HCl

Catalog No. A11204
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LXR-like receptors 激动剂

GW3965 HCl是一种选择性的口服活性肝X受体（LXR）完全激动剂。了解更多

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- Mohácsik P, .et al. A Transgenic Mouse Model for Detection of Tissue-Specific Thyroid Hormone Action, Endocrinology, 2018, Feb 1;159(2):1159-1171 PMID: 29253128
- Pencheva N, .et al. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation., Cell., 2014, 156(5):986-1001 PMID: 24581497
- Bin Dong, .et al. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway, J Lipid Res., 2013, May; 54(5): 1241-1254. PMID: 23427282
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AC-55649

Catalog No. A20078
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Human RARβ2 receptor agonist

AC-55649 is a potent, highly isoform-selective agonist of human RARβ2 receptor, with a pEC50 of 6.9. 了解更多

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VCE-004.8

Catalog No. A18549
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PPARγ and CB2 receptor dual agonist

VCE-004.8, a semi-synthetic multitarget cannabinoquinoid, is a specific PPARγ and CB2 receptor dual agonist with potent anti-inflammatory activity. 了解更多

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Fexaramine

Catalog No. A21771
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FXR agonist

Fexaramine is a small molecule farnesoid X receptor (FXR) agonist with 100-fold increased affinity relative to natural compounds. 了解更多

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RGX-104 free Acid

Catalog No. A21513
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LXR agonist

RGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 了解更多

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INT-767

Catalog No. A21494
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dual FXR/TGR5 agonist

INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively. 了解更多

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FICZ

Catalog No. A21452
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AhR agonist

FICZ is a potent aryl hydrocarbon receptor (AhR) agonist with a Kd of 70 pM. 了解更多

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Indeglitazar

Catalog No. A21148
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PPAR agonist

Indeglitazar is an orally available peroxisome proliferator-activated receptor (PPAR) pan-agonist for all three PPAR subtypes alpha (α), delta (δ) and gamma (γ). 了解更多

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Arhalofenate

Catalog No. A21135
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PPARγ agonist

Arhalofenate (MBX 102) is a selective partial agonist of peroxisome proliferator-activated receptor (PPAR)-γ, used for the treatment of type 2 diabetes. 了解更多

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Tesaglitazar

Catalog No. A20891
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PPAR alpha/gamma agonist

Tesaglitazar is a dual peroxisome proliferator-activated receptor (PPAR) alpha/gamma agonist that is more potent on PPARγ than on PPARα, with EC50s of 13.4 μM and 3.6 μM for rat PPARα and human PPARα, respectively. 了解更多

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ITE

Catalog No. A12565
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AhR agonist

ITE is a potent endogenous agonist of aryl hydrocarbon receptor (AhR), binding directly to AHR, with a Ki of 3 nM. ITE also has immunosuppressive activity. 了解更多

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Nidufexor

Catalog No. A12625
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FXR agonist

Nidufexor is a farnesoid X receptor (FXR) agonist. 了解更多

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Cilofexor

Catalog No. A13143
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FXR agonist

Cilofexor (GS-9674) is a farnesoid X receptor (FXR) agonist. 了解更多

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Leriglitazone

Catalog No. A18636
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PPAR gamma agonist

Leriglitazone is a peroxisome proliferator activated receptor (PPAR) gamma agonist. 了解更多

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WYC-209

Catalog No. A19001
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RAR agonist

WYC-209, a synthetic retinoid, is a retinoic acid receptor (RAR) agonist. 了解更多

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BR102375

Catalog No. A18849
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PPAR γ agonist

BR102375 is a non-TZD peroxisome proliferator-activated receptor γ (PPAR γ) full agonist for the treatment of type 2 diabetes, reveals EC50 value of 0.28?μM and Amax ratio?of 98%. 了解更多

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Etofylline

Catalog No. A17491
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PPAR agonist

Etofylline, also known as BRN-0251760, is a peroxisome proliferator-activated receptor (PPAR) agonist used to treat respiratory and cardiovascular disorders. Etofylline is often used as a bronchodilator. 了解更多

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GW3965

Catalog No. A15100
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Liver X Receptor 激动剂

GW3965是hLXRα和hLXRβ的有效选择性LXR激动剂，EC50分别为190和30 nM。了解更多

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- B Dong ,etc. High-fructose diet downregulates long-chain acyl-CoA synthetase 3 expression in liver of hamsters via impairing LXR/RXR signaling pathway. Journal of lipid research, 2013, 54(5), 1241-1254.
- N Pencheva ,etc. Broad-spectrum therapeutic suppression of metastatic melanoma through nuclear hormone receptor activation. Cell, 2014, 156(5), 986-1001.
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GW 501516

Catalog No. A11437
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PPARδ receptor 激动剂

GW501516是一种合成pparδ特异性激动剂，对pparδ (ki=1.1 nm)显示出高亲和力，其选择性超过pparα和pparγ的1000倍。了解更多

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