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搜索结果：“jwh 250”

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TRx0237 (LMTX) mesylate

Catalog No. A16124
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tau protein aggregation 抑制剂

TRx0237 (LMTX) mesylate是第二代tau蛋白聚集抑制剂，可用于治疗阿尔茨海默氏病（AD）和额颞痴呆。了解更多

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Vc-MMAD

Catalog No. A15273
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Tubulin 抑制剂

Vc-MMAD由ADC接头（Val-Cit）和有效的微管蛋白抑制剂（MMAD）组成，Vc-MMAD是抗体药物偶联物。" 了解更多

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Ixabepilone

Catalog No. A11449
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microtubule 抑制剂

Ixabepilone是epothilone B类似物。了解更多

Product Citations (3)

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- Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006
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Cabazitaxel

Catalog No. A11831
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Microtubule Associated 抑制剂

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。了解更多

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- Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509