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搜索结果：“abl”

“abl”的搜索结果

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Upamostat

Catalog No. A21035
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serine protease inhibitor

Upamostat is a serine protease inhibitor. Upamostat is the orally available prodrug of the WX-UK1, which is a urokinase plasminogen activator (uPA) inhibitor. 了解更多

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DBPR108

Catalog No. A21833
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DPP4 inhibitor

DBPR108 is a potent, selective, and orally bioavailable dipeptide-derived inhibitor of DPP4 with IC50 of 15 nM; no inhibition on DDP8 and DPP9. 了解更多

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Dutogliptin

Catalog No. A21573
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DPP4 inhibitor

Dutogliptin (PHX-1149 free base) is an orally available, potent, and selective dipeptidyl peptidase-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus. 了解更多

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BOC-D-FMK

Catalog No. A11356
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caspase inhibitor

Boc-D-FMK is a cell-permeable, irreversible and broad spectrum caspase inhibitor; inhibits apoptosis stimulated by TNF-α with an IC50 of 39 ?M. 了解更多

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Lanabecestat

Catalog No. A12282
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BACE1 inhibitor

Lanabecestat (AZD3293) is a potent, highly permeable, orally active and blood-brain barrier penetrating BACE1 inhibitor with a Ki of 0.4 nM. 了解更多

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ML604440

Catalog No. A18826
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proteasome β1i (LMP2) subunit inhibitor

ML604440 is a potent, specific and cell permeable proteasome β1i (LMP2) subunit inhibitor. 了解更多

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SNJ-1945

Catalog No. A17243
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Calpain inhibitor

SNJ-1945 is a calpain inhibitor with more favorable retinal penetration, high oral bioavailability, and long half-life. SNJ1945 rescued defective function in lissencephaly. 了解更多

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Z-FL-COCHO

Catalog No. A13502
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Cathepsin S 抑制剂

Z-FL-COCHO是新型的组织蛋白酶S抑制剂。了解更多

Product Citations (3)

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- Fu R, .et al. Cathepsin S activation contributes to elevated CX3CL1 (fractalkine) levels in tears of a Sjogren's syndrome murine model, Sci Rep, 2020, Jan 29;10(1):1455 PMID: 31996771
- Klinngam W, .et al. Inhibition of Cathepsin S Reduces Lacrimal Gland Inflammation and Increases Tear Flow in a Mouse Model of Sj?gren's Syndrome, Sci Rep, 2019, Jul 2;9(1):9559 PMID: 31267034
- Chen CY, .et al. Omega-3 polyunsaturated fatty acids reduce preterm labor by inhibiting trophoblast cathepsin S and inflammasome activation, Clin Sci (Lond), 2018, Oct 29;132(20):2221-2239 PMID: 30287519