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VP3.15 dihydrobromide

Catalog No. A21789
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PDE7/GSK3 inhibitor

VP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多

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U18666A

Catalog No. A20195
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cholesterol synthesis/Hedgehog inhibitor

U18666A, a cell permeable drug, is a cholesterol synthesis and transport inhibitor. 了解更多

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VP3.15

Catalog No. A18538
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dual PDE7/GSK-3 inhibitor

VP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多

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BC2059

Catalog No. A14381
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beta-catenin inhibitor

BC2059 is an orally bioavailable and potent beta-catenin inhibitor. 了解更多

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- Ji-Hye Jung, .et al. CXCR2 Inhibition in Human Pluripotent Stem Cells Induces Predominant Differentiation to Mesoderm and Endoderm Through Repression of mTOR, β-Catenin, and hTERT Activities, Stem Cells Dev, 2016, Jul 1; 25(13): 1006-1019 PMID: 27188501