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CI 976

Catalog No. A16370
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ACAT/SOAT 抑制剂

CI 976是肝和肠酰基辅酶A胆固醇酰基转移酶（ACAT）和固醇O-酰基转移酶（SOAT）的三甲氧基脂肪酸苯胺抑制剂。Cl 976降低非高密度脂蛋白（non-HDL）胆固醇并增加HDL-胆固醇浓度。了解更多

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K-252a

Catalog No. A14001
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K-252a是最初从诺卡氏菌属（Nocardiopsis sp.）的培养液中分离的代谢产物。实验表明，在高浓度下，该化合物是ATP竞争性环核苷酸依赖性蛋白激酶的抑制剂。了解更多

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NBMPR

Catalog No. A13701
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ENT1 抑制剂

NBMPR是一种核苷类似物，可竞争性抑制平衡的核苷转运蛋白1（大鼠和人的Kd = 0.1-1.0 nM，IC50s = 4.6和3.6 nM）。了解更多

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CAY10650

Catalog No. A14355
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cPLA2α 抑制剂

CAY10650是一种高效（IC50 = 12 nM）cPLA2α抑制剂。了解更多

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TP-434 (Eravacycline)

Catalog No. A13887
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TP-434 (Eravacycline)是一种新型的广谱氟环素抗生素，对表达主要抗生素抗性机制（包括四环素特异性外排和核糖体保护）的细菌具有活性。了解更多

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- Zewen Wen, .et al. In vitro activity and adaptation strategies of eravacycline in clinical Enterococcus faecium isolates from China, J Antibiot (Tokyo), 2022, Sep;75(9):498-508 PMID: 35896611
- Fan Zhang, .et al. Eravacycline activity against clinical S. aureus isolates from China: in vitro activity, MLST profiles and heteroresistance, BMC Microbiol, 2018, 18: 211 PMID: 30545293
- Jin-xin Zheng, .et al. Overexpression of OqxAB and MacAB efflux pumps contributes to eravacycline resistance and heteroresistance in clinical isolates of Klebsiella pneumoniae, Emerg Microbes Infect, 2018, 7: 139 PMID: 30068997
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Cilliobrevin D

Catalog No. A12913
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cytoplasmic dynein 拮抗剂

Ciliobrevin D是第一个特定的细胞质动力蛋白小分子拮抗剂。了解更多

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BCH

Catalog No. A13370
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LAT1 抑制剂

BCH是L型氨基酸转运蛋白LAT1的抑制剂。通过激活KB，Saos2和C6癌细胞系中的半胱氨酸蛋白酶抑制生长并诱导凋亡。了解更多

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Cangrelor (AR-C69931)

Catalog No. A12843
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Cangrelor (AR-C69931)是一种有效的静脉内二磷酸腺苷受体拮抗剂。了解更多

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- Satoru Koyanagi, .et al. Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia, Nat Commun, 2016, 7: 13102 PMID: 27739425
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ANX-510

Catalog No. A12370
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ANX-510是基于叶酸的生物调节剂，具有潜在的抗肿瘤活性。5,10-亚甲基四氢叶酸（MTHF）稳定氟尿嘧啶代谢物5-5-氟-2'-脱氧尿苷-5'-O-单磷酸酯（FdUMP）与目标酶胸苷酸合酶的共价结合，从而抑制胸苷酸合酶，三磷酸胸苷的消耗（TTP），DNA的必要成分以及肿瘤细胞死亡。与亚叶酸钙不同，作为叶酸的活性形式的MTHF不需要代谢活化，并且可以提高氟尿嘧啶的化学治疗效果，且毒性较低。了解更多

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- Chern Chiuh Woo, .et al. Downregulating serine hydroxymethyltransferase 2 (SHMT2) suppresses tumorigenesis in human hepatocellular carcinoma, Oncotarget, 2016, Aug 16; 7(33): 53005-53017 PMID: 27391339
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Pimecrolimus

Catalog No. A10732
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Pimecrolimus是一种天然的子囊霉素大内酰胺，可与大亲霉素12（FKBP-12）结合并抑制钙调神经磷酸酶和脯氨酰异构酶（旋转异构酶）。了解更多

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BTZ043 (BTZ038, BTZ044) Racemate

Catalog No. A10165
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DprE1 抑制剂

BTZ043 (BTZ038,BTZ044) Racemate 抑制癸二烯基磷酸基-β-d-核糖2α-表异构酶，它是一种产生致病细菌结核分枝杆菌细胞壁的酶。了解更多

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