“Ligand-gated Ion Channels”的搜索结果
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integrase (IN) inhibitor
Raltegravir is a potent integrase (IN) inhibitor, used to treat HIV infection.
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non-nucleoside reverse transcriptase inhibitor
Loviride (R 89439) is a non-nucleoside reverse transcriptase inhibitor (NNRTI), with an IC50 of 0.3 ?M for reverse transcriptase from HIV-1. Loviride (R 89439) inhibits HIV-1, HIV-2 and SIV replication in MT-4 cells.
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HCV RNA replication inhibitor
Sofosbuvir impurity A, an diastereoisomer of sofosbuvir, is the impurity of sofosbuvir. Sofosbuvir (PSI-7977) is an inhibitor of HCV RNA replication, demonstrates potent anti-hepatitis C virus activity.
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HCV RNA replication inhibitor
Sofosbuvir impurity C is the less active impurity of Sofosbuvir, Sofosbuvir is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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HCV RNA replication inhibitor
PSI-7976 is the isomer of PSI-7977. PSI-7977 is an active inhibitor of HCV RNA replication in the HCV replicon assay, demonstrates potent anti-hepatitis C virus (HCV) activity.
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HIV-1 nucleotide reverse transcriptase inhibitor
Tenofovir alafenamide hemifumarate (GS-7340 hemifumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
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HIV-1 nucleotide reverse transcriptase inhibitor
Tenofovir alafenamide fumarate (GS-7340 fumarate) is an investigational oral prodrug of Tenofovir. Tenofovir is a HIV-1 nucleotide reverse transcriptase inhibitor.
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HCV replication inhibitor
R-1479 is a specific inhibitor of HCV replication in the HCV subgenomic replicon system (IC50=1.28 μM).
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HCV NS5B polymerase inhibitor
Mericitabine (RG 7128; R-7128) is a nucleoside inhibitor of the HCV NS5B polymerase that acts as an RNA chain terminator and prevents elongation of RNA transcripts during replication.
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HIV-1 integrase inhibitor
HIV-1 integrase inhibitor 2, in the treatment of human immunodeficiency virus (HIV) infection.
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nucleoside analogue reverse transcriptase inhibitor
Zalcitabine is a potent nucleoside analogue reverse transcriptase inhibitor used in the treatment of HIV infection.
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NNRT inhibitor
MIV-150 is a nonnucleoside reverse transcriptase (NNRT) inhibitor, blocking HIV-1 and HIV-2 infections, with an EC50<1 nM against HIV-1/HIV-2MN.
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HBV capsid assembly modulator
GLP-26 is a HBV capsid assembly modulators (CAM), inhibits HBV DNA replication in Hep AD38 system (IC50=3 nM), and reduces cccDNA by >90% at 1 μM. GLP-26 disrupts the encapsidation of pre-genomic RNA, causes nucleocapsid disassembly and reduces cccDNA pools.
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CCR8 抑制剂
ML604086 is a selective CCR8 inhibitor, inhibiting CCL1 binding to CCR8 on circulating T-cells. ML604086 inhibits CCL1 mediated chemotaxis and increases in intracellular Ca2+ concentrations.
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CCR8 激动剂
LMD-009 is a selective CCR8 nonpeptide agonist. LMD-009 mediates chemotaxis, inositol phosphate accumulation, and calcium release in high potencies with EC50s from 11 to 87 nM.
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HIV maturation 抑制剂
GSK2838232是一种新型的人类免疫病毒(HIV)成熟抑制剂,正在开发用于治疗慢性HIV感染。
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Antiviral fusion 抑制剂
Presatovir (GS-5806)是一种新型的,生物利用的RSV融合抑制剂,可抗多种RSV A和B临床分离株(平均EC50 = 0.43 nM)。
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HSV DNA replication 抑制剂
Fiacitabine是单纯疱疹病毒(HSV)DNA复制的选择性抑制剂,HSV1和HSV2的IC50值分别为2.5 nM和12.6 nM。
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HIV fusion 抑制剂
Enfuvirtide Acetate (T-20)是一个36个氨基酸的肽段,对应于gp41(HIV-1包膜蛋白的跨膜亚基)区域。
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HCV replication 抑制剂
RO-9187是复制系统中HCV病毒复制的有效抑制剂(IC(50)= 171+/-12 nM;CC(50)> 1 mM)。
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HIV-1 maturation 抑制剂
Bevirimat (PA-457,MPC-4326,YK FH312) 是HIV-1病毒颗粒成熟抑制剂。
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- Mingzhang Wang, .et al. Quenching protein dynamics interferes with HIV capsid maturation, Nat Commun, 2017, 8: 1779 PMID: 29176596
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HIV maturation 抑制剂
GSK2838232是一种新型的人类免疫病毒(HIV)成熟抑制剂,正在开发用于治疗慢性HIV感染。
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RSV fusion 抑制剂
TMC353121是一种有效的体外RSV融合抑制剂,pEC50 为 9.9。抗病毒药,也是治疗RSV疾病的新型候选药物。
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HCV replication 抑制剂
Anguizole是一种抑制HCV复制并改变NS4B亚细胞分布的小分子。
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- Choi M, .et al. A hepatitis C virus NS4B inhibitor suppresses viral genome replication by disrupting NS4B-s dimerization/multimerization as well as its interaction with NS5A, Virus Genes., 2013, Dec;47(3):395-407 PMID: 23868571