Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes. 了解更多

Angiotensin III is an angiotensin 1 (AT1) and AT2 receptor agonist. 了解更多

IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM. 了解更多

Exendin-4 (Exenatide), a 39 amino acid peptide, is a long-acting glucagon-like peptide-1 receptor agonist with an IC50 of 3.22 nM. 了解更多

BAY 2416964 is a potent and orally active aryl hydrocarbon receptor (AHR) antagonist extracted from patent WO2018146010A1, example 192, has an IC50 of 341 nM. BAY 2416964 has the potential for solid tumors treatment. 了解更多

CYM50308 (ML248) is a potent, selective and high affinity sphingosine-1-phosphate receptor 4 (S1P4-R) agonist with an EC50 of 56 nM. 了解更多

MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively. 了解更多

SR8278 is a competitive nuclear heme receptor REV-ERB synthetic antagonist. 了解更多

WAY-169916 is a pathway-selective inhibitor of estrogen receptor (ER) that acts by inhibiting NF-kB transcriptional activity. 了解更多

SGA360 is a selective modulator of aryl hydrocarbon (Ah) receptor that exhibits anti-inflammatory properties. 了解更多

ONO-8130 is an orally available antagonist of EP1 receptor. 了解更多

Cytosporone B (Csn-B; Dothiorelone G) is a naturally occurring nuclear orphan receptor Nur77/NR4A1 agonist with an EC50 of 0.278 nM. 了解更多

RO5203648 hydrochloride is a partial agonist of Trace amine-associated receptor 1 (TAAR1). 了解更多

BMS-986188 is a novel Potent and Selective Positive Allosteric Modulator of the delta-Opioid Receptor. 了解更多

BMS-986187 is a potent and selective positive allosteric modulator (PAM) of the δ-opioid receptor and a G-protein-biased allosteric agonist. 了解更多

Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. 了解更多

A-784168 is a potent and selective antagonist of Vanilloid receptor type 1 (TRPV1). 了解更多

5-HT3 antagonist-4i is a 5-HT3 receptor antagonist which modulates the serotonergic system. 了解更多

Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. 了解更多

RO495 (CS-2667) is a potent inhibitor of Non-receptor tyrosine-protein kinase 2 (TYK2). 了解更多

Emedastine is an orally active, selective and high affinity histamine H1 receptor antagonist with a Ki value of 1.3 nM. 了解更多

S-23 is an orally active selective androgen receptor modulator (SARM) with a Ki of 1.7 nM. 了解更多

AC-262536 is a selective androgen receptor (SAR) molecule. It has partial agonist activity with respect to testosterone and suppresses luteinizing hormone. 了解更多

ALK2-IN-1 (BLU-782) is a potent and selective inhibitor of Activin receptor-like kinase (ALK2) mutant R206H with binding IC50 of <10 nM. 了解更多

Practolol is a potent and selective β1-adrenergic receptor antagonist. Practolol can be used for the research of cardiac arrhythmias. 了解更多

SSD114 hydrochloride is a novel GABAB receptor positive allosteric modulator. 了解更多

GR 125743 is a selective 5-HT1B/1D receptor antagonist, with pKis of 8.85 and 8.31 for wild-type h5-HT1B and wild-type h5-HT1D, respectively. 了解更多

Cholesterol is also an endogenous estrogen-related receptor α (ERRα) agonist. 了解更多

SNG-1153 is a modulator of estrogen receptor ER-alpha36. 了解更多

(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively. 了解更多

ZD-4190 is a potent, orally available inhibitor of the vascular endothelial cell growth factor receptor 2 (VEGFR2) and of epidermal growth factor receptor (EGFR) signalling, used for the treatment of cancer. 了解更多

Methylprednisolone (NSC-19987, Medrol) acetate is a synthetic glucocorticoid receptor agonist, used to achieve prompt suppression of inflammation. 了解更多

PF-04995274 is a partial agonist of the serotonin (5-HT) receptor subtypes 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E (Kis = 0.36, 0.46, 0.15, and 0.32 nM, respectively, in a radioligand binding assay).1 It increases cAMP levels in HEK293 cells expressing 5-HT4A, 5-HT4B, 5-HT4D, and 5-HT4E receptors (EC50s = 0.47, 0.36, 0.37, and 0.26 nM, respectively, for the human recombinant receptors). PF-04995274 decreases scopolamine-induced increases in the distance traveled in the Morris water maze in rats when administered at a dose of 0.032 mg/kg. 了解更多

AVN-101 is a very potent 5-HT7 receptor antagonist, with slightly lesser potency toward 5-HT6, 5-HT2A, and 5HT-2C receptors. It is a milti-target drug candidate for the treatment of CNS disorders. 了解更多

Ro0711401 is a mGlu1 receptor agonist. 了解更多

SB203186 is potent 5-HT4 receptor antagonist. 了解更多

ATPO is a potent and Selective Ampa Receptor Antagonist. 了解更多

Xanthurenic acid is a putative endogenous Group II metabotropic glutamate receptor agonist, on sensory transmission in the thalamus. 了解更多

Benzetimide hydrochloride is a muscarinic acetylcholine receptor antagonist. 了解更多

Carazolol is a non-specific β-adrenergic receptor blocking agent and binds to β receptors irreversibly. 了解更多

Quipazine maleate is a selective 5-HT receptor agonist that promotes the proliferation and apoptosis of human hepatocyte strain of L-02 strain and could also exert an excitatory effect on raphe neurons via stimulation of 5-HT2A receptors. 了解更多

ACT-389949 is a first-in-class, potent and selective and agonist of formyl peptide receptor type 2 (FPR2)/Lipoxin A4 receptor (ALX), with an EC50 of 3 nM for FPR2/ALX internalization into monocytes. 了解更多

EMD-66684 is a non-peptide angiotensin II receptor antagonist. 了解更多

Cgs 20625 is a benzodiazepine receptor agonist. 了解更多

Ro 19-4603 is a benzodiazepine receptor inverse agonist. 了解更多

Flutonidine is an alpha2-Adrenergic receptor agonist. 了解更多

Cetrorelix diacetate (SB-075 diacetate) is a potent gonadotropin-releasing hormone (GnRH) receptor antagonist with an IC50 of 1.21 nM. 了解更多

DNQX Disodium is a water-soluble form of selective non-NMDA receptor antagonist DNQX. 了解更多

SJM-3 is a positive allosteric modulator of different isoforms of the GABAA receptor. SJM-3 binds at the high-affinity benzodiazepine binding site at the α+/γ- subunit interface. 了解更多