“AG 013736”的搜索结果

产品 401 到 450 共 3340个

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  1. Agmatine sulfate

    Catalog No. A20485
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    NO synthase inhibitor
    Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor. 了解更多
  2. VUF10460

    Catalog No. A20484
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    histamine H4 receptor agonist
    VUF10460 is a non-imidazole histamine H4 receptor agonist; binds to rat H4 receptor with a pKi of 7.46. 了解更多
  3. PP7

    Catalog No. A20483
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    PB1-PB2 interaction inhibitor
    PP7 is a potent PB1-PB2 interaction inhibitor with an IC50 of 8.6 μM, and their inhibition against viral polymerase activity (IC50=9.5 μM). 了解更多
  4. Cadazolid

    Catalog No. A20481
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    oxazolidinone antibiotic
    Cadazolid (ACT-179811) is a new oxazolidinone antibiotic with potent activity against Clostridium difficile. 了解更多
  5. TA-7552

    Catalog No. A20473
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    cholesterol-lowering agent
    TA-7552 is a potent cholesterol-lowering agent. 了解更多
  6. Fumarate hydratase-IN-1

    Catalog No. A20471
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    fumarate hydratase inhibitor
    Fumarate hydratase-IN-1 (compound 2) is a cell-permeable fumarate hydratase inhibitor. Fumarate hydratase-IN-1 has antiproliferative activity against several cancer cell lines with a mean IC50 of 2.2 μM. 了解更多
  7. CCR2 antagonist 3

    Catalog No. A20467
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    CCR2 antagonist
    CCR2 antagonist 3 is a chemokine receptor 2 (CCR2) antagonist. 了解更多
  8. Tiodazosin

    Catalog No. A20463
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    ostsynaptic alpha adrenergic receptor antagonist
    Tiodazosin is a potent competitive postsynaptic alpha adrenergic receptor antagonist. 了解更多
  9. S1p receptor agonist 1

    Catalog No. A20461
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    S1P receptor agonist
    S1p receptor agonist 1 is an S1P receptor agonist extracted from patent WO 2015039587 A1, compound example 2. 了解更多
  10. Trifarotene

    Catalog No. A20458
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    RAR agonist
    Trifarotene (CD5789) is a retinoic acid receptor (RAR) agonist with Kdapp of 2, 15 and 500 nM for RARγ, RARβ and RARα, respectively. 了解更多
  11. TCS-OX2-29

    Catalog No. A20457
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    OX2R antagonist
    TCS-OX2-29 is a potent, high affinities and selective orexin-2 receptor (OX2R) antagonist with an IC50 value of 40 nM and a pKI value of 7.5. TCS-OX2-29 displays ~250-fold selectivity for OX2 over OX1. 了解更多
  12. mPGES1-IN-3

    Catalog No. A20454
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    mPGES-1 inhibitor
    mPGES1-IN-3 (Compound 17d) is a potent and selective microsomal prostaglandin E2 synthase-1 (mPGES-1) inhibitor, which exhibits excellent mPGES-1 enzyme (IC50: 8 nM), cell (A549 IC50: 16.24 nM) and human whole blood potency (IC50: 249.9 nM). 了解更多
  13. PGD2-IN-1

    Catalog No. A20451
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    DP antagonist
    PGD2-IN-1 is an antagonist of DP extracted from patent WO 2006044732 A2, example 15 (d); has an IC50 of 0.3 nM. 了解更多
  14. Y-9738

    Catalog No. A20449
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    Y-9738 is a hypolipidemic agent. 了解更多
  15. CGP 25454A

    Catalog No. A20448
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    dopamine autoreceptor antagonist
    CGP 25454A is a novel and selective presynaptic dopamine autoreceptor antagonist. 了解更多
  16. WAY-200070

    Catalog No. A20442
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    ERRβ agonist
    WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM. 了解更多
  17. MM-589

    Catalog No. A20440
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    WDR5/MLL inhibitor
    MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. 了解更多
  18. CCR5 antagonist 1

    Catalog No. A20439
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    CCR5 antagonist
    CCR5 antagonist 1 is a CCR5 antagonist which can inhibit HIV replication extracted from WO 2004054974 A2. 了解更多
  19. BAR502

    Catalog No. A20433
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    dual FXR and GPBAR1 agonist
    BAR502 is a dual FXR and GPBAR1 agonist with IC50 values of 2 μM and 0.4 μM, respectively. 了解更多
  20. BAR501

    Catalog No. A20429
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    GPBAR1 agonist
    BAR501 is a potent and selective agonist of GPBAR1 with an EC50 of 1 μM. 了解更多
  21. Urolithin A

    Catalog No. A20426
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    Urolithin A, a gut-microbial metabolite of ellagic acid, exerts anti-inflammatory, antiproliferative, and antioxidant properties. Urolithin A induces autophagy and apoptosis, suppresses cell cycle progression, and inhibits DNA synthesis. 了解更多
  22. SR0987

    Catalog No. A20422
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    RORγt agonist
    SR0987, a SR1078 analog, is a RORγt agonist, with an EC50 of 800 nM. SR0987 increases IL17 expression while repressing the expression of PD-1. 了解更多
  23. Nitromifene

    Catalog No. A20417
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    ER antagonist
    Nitromifene is an antagonist of estrogen receptor (ER). 了解更多
  24. Chlordantoin

    Catalog No. A20416
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    antifungal drug
    Chlordantoin is an antifungal drug which can be used to treat vaginal candidiasis. 了解更多
  25. Xenalamine

    Catalog No. A20411
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    Xenalamine is a synthetic antiviral agent. 了解更多
  26. IT1t

    Catalog No. A20408
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    CXCR4 antagonist
    IT1t is a potent CXCR4 antagonist; inhibits CXCL12/CXCR4 interaction with an IC50 of 2.1 nM. 了解更多
  27. Tomivosertib

    Catalog No. A20407
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    MNK1/MNK2 inhibitor
    Tomivosertib (eFT508) is a potent, highly selective, and orally bioavailable MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. 了解更多
  28. LXRβ agonist-2

    Catalog No. A20405
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    LXRβ agonist
    LXRβ agonist-2 is a highly potent and β-selective liver X receptor (LXRβ) agonist with EC50 of 7 nM, displays 28.5-fold selectivity over LXRα (EC50=200 nM) and used in the treatment of atherosclerosis. 了解更多
  29. Org41841

    Catalog No. A20396
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    LHCGR/TSHR agonist
    Org41841 is a partial agonist of both luteinizing hormone/chorionic gonadotropin receptor (LHCGR) and thyroid-stimulating hormone receptor (TSHR) with EC50s of 0.2 and 7.7 μM, respectively. 了解更多
  30. HCH6-1

    Catalog No. A20395
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    FPR1 antagonist
    HCH6-1 is a competitive antagonist of Formyl peptide receptor 1 (FPR1), an emerging therapeutic target for the discovery of drugs to treat neutrophilic inflammatory diseases. 了解更多
  31. BMS-986020

    Catalog No. A20393
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    LPA1 antagonist
    BMS-986020 is a high-affinity lysophosphatidic acid receptor 1 (LPA1) antagonist. 了解更多
  32. B220

    Catalog No. A20391
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    B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV). 了解更多
  33. PD 117519

    Catalog No. A20388
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    A2A adenosine agonist
    PD 117519 (CI947) is an A2A adenosine agonist which has shown oral antihypertensive activity in pharmacological animal models. 了解更多
  34. AGN 194078

    Catalog No. A20387
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    RARα agonist
    AGN 194078 is a selective RARα agonist with a Kd and EC50 of 3 and 112 nM, respectively. 了解更多
  35. Closthioamide

    Catalog No. A20385
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    DNA gyrase inhibitor
    Closthioamide is a potent inhibitor of bacterial DNA gyrase and highly active against Ec, MRSA, VRE and Mv), with MICs of 9.00 μM, 0.58 μM, 0.58 μM and 72.03 μM respectively. 了解更多
  36. Adenosine antagonist-1

    Catalog No. A20383
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    AA3R antagonist
    Adenosine antagonist-1 is an adenosine A3 receptor (AA3R) antagonist. 了解更多
  37. MPT0B392

    Catalog No. A20378
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    microtubule-depolymerizing agent
    MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line. 了解更多
  38. Fenobam

    Catalog No. A20372
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    mGluR5 antagonist
    Fenobam is a selective, orally active, and non-competitive mGluR5 antagonist acting at an allosteric modulatory site (Kd values are 54 and 31 nM for rat and human recombinant mGlu5 receptors, respectively). 了解更多
  39. RMI 10874

    Catalog No. A20370
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    RMI 10874 is a tilorone analogue. Tilorone is a small-molecule, orally bioavailable antiviral agent. RMI 10874 completely abolishes lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone. 了解更多
  40. TBHQ

    Catalog No. A20358
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    Nrf2 activator
    TBHQ (tert-Butylhydroquinone) is a widely used Nrf2 activator, protects against Doxorubicin (DOX)-induced cardiotoxicity through activation of Nrf2. 了解更多
  41. 9-Propenyladenine

    Catalog No. A20357
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    9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV. 了解更多
  42. Spaglumic Acid

    Catalog No. A20356
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    Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain. 了解更多
  43. Thiazolidinone-Derivatives-1

    Catalog No. A20355
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    Thiazolidinone-Derivatives-1 is an antiulcer agent which inhibits the secretion of gastric acid. 了解更多
  44. JYL 1421

    Catalog No. A20350
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    TRPV1 receptor antagonist
    JYL 1421 is a TRPV1 receptor antagonist, with an IC50 of 8 nM. 了解更多
  45. MDL 19301

    Catalog No. A20341
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    MDL 19301 is a nonsteroidal, anti-inflammatory agent. 了解更多
  46. (+)-Dihydrexidine hydrochloride

    Catalog No. A20339
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    dopamine D1 receptor agonist
    (+)-Dihydrexidine hydrochloride ((+)-DAR-0100 hydrochloride) is a dopamine D1 receptor agonist with an EC50 of 72± 21 nM. 了解更多
  47. 2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide

    Catalog No. A20334
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    2-(E-2-decenoylamino)ethyl 2-(cyclohexylethyl) sulfide is a compound that inhibits stress-induced ulcer and low toxicity, and can maintain the content of phospholipase A2 and prostaglandin E2 in ulcerated rats induced by water immersed restrained stress. 了解更多
  48. FT011

    Catalog No. A20333
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    FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis. 了解更多
  49. SYM 2081

    Catalog No. A20332
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    kainate receptors agonist
    SYM 2081 is a high-affinity ligand and potent, selective agonist of kainate receptors, inhibits [3H]-kainate binding with an IC50 of 35 nM, almost 3000- and 200-fold selectivity for kainate receptors over AMPA and NMDA receptors respectively. 了解更多
  50. GPR120-IN-1

    Catalog No. A20328
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    Gpr120 agonist
    GPR120-IN-1 is a selective Gpr120 agonist with a logEC50 of ?7.62. 了解更多

产品 401 到 450 共 3340个

每页
页面:
  1. 7
  2. 8
  3. 9
  4. 10
  5. 11

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