Estrogen Receptors

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IRL-2500

Catalog No. A13638
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ETBR 拮抗剂

IRL-2500是一种有效的选择性ETBR拮抗剂。它显示了对ETB受体的一些选择性（对于ETB和ETA受体，IC50值分别为1.3和94 nM）。了解更多

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Endoxifen

Catalog No. A12639
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Estrogen receptor 拮抗剂

Endoxifen是他莫昔芬的次生代谢产物。它是负责他莫昔芬在ER阳性乳腺癌中有效性的主要代谢物。Endoxifen Z-isomer抑制hERG, 这种作用具有浓度依赖性, IC50值为1.6μM。了解更多

Product Citations (2)

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- Marina Arino Martin, .et al. Photolytic fate of (E)- and (Z)-endoxifen in water and treated wastewater exposed to sunlight, Environ Res, 2021, Apr 3;197:111121 PMID: 33823193
- Martin MA, .et al. Photodegradation of (E)- and (Z)-Endoxifen in water by ultraviolet light: Efficiency, kinetics, by-products, and toxicity assessment, Water Res, 2019, Dec 29;171:115451 PMID: 31901682
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AZD9496

Catalog No. A15822
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estrogen receptor downregulator and 拮抗剂

AZD9496是一种有效的生物选择性雌激素受体下调剂和拮抗剂。了解更多

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(E/Z)-4-hydroxy Tamoxifen

Catalog No. A12532
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Estrogen receptor 拮抗剂

(E/Z)-4-hydroxy Tamoxifen是他莫昔芬的活性代谢产物，是一种选择性雌激素受体（ER）调节剂，广泛用于乳腺癌的治疗和化学预防治疗。了解更多

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- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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H3B-6545

Catalog No. A20100
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Estrogen receptor antagonist

H3B-6545 is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多

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XCT 790

Catalog No. A13299
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ERRα 拮抗剂/inverse 激动剂

XCT 790是ERRα的强效特异性反向激动剂。了解更多

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Enclomiphene citrate

Catalog No. A21830
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oestrogen receptor antagonist

Enclomiphene citrate is a potent and orally active oestrogen receptor antagonist, with antioestrogenic property. 了解更多

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AZD9496 maleate

Catalog No. A21726
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estrogen receptor (ERα) antagonist

AZD9496 maleate is a potent and selective estrogen receptor (ERα) antagonist with IC50 of 0.28 nM. AZD9496 maleate is an orally bioavailable selective oestrogen receptor degrader (SERD). 了解更多

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H3B-6545 Hydrochloride

Catalog No. A21629
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estrogen receptor covalent antagonist

H3B-6545 Hydrochloride is an oral, selective estrogen receptor covalent antagonist (SERCA). 了解更多

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Fulvestrant R enantiomer

Catalog No. A21545
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estrogen receptor antagonist

Fulvestrant R enantiomer (ICI 182780 R enantiomer; ZD 9238 R enantiomer; ZM 182780 R enantiomer) is the less active R enantiomer of Fulvestrant. Fulvestrant is a potent estrogen receptor antagonist with an IC50 of 9.4 nM. 了解更多

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Tamoxifen Citrate

Catalog No. A10885
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Estrogen receptor 拮抗剂

Tamoxifen Citrate是哺乳动物甾醇异构酶的选择性和有效抑制剂。了解更多

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- Renu Sudhakar, .et al. Bazedoxifene, a Postmenopausal Drug, Acts as an Antimalarial and Inhibits Hemozoin Formation, Microbiol Spectr, 2022, Jun 29;10(3) PMID: 35616371
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347