Doramapimod (BIRB-796)

目录号: A10148

p38 MAPK 抑制剂

Doramapimod (BIRB-796)

Doramapimod (BIRB-796) Chemical Structure

CAS NO. 285983-48-4

Doramapimod(BIRB 796)是p38 MAPK的小分子抑制剂,在调节促炎细胞因子的产生中起关键作用。

库存: 现货

规格 价格 数量
5 mg
¥ 210.00
10 mg
¥ 350.00
50 mg
¥ 945.00
100 mg
¥ 1,260.00
10mM * 1mL in DMSO
¥ 350.00
Warning 产品仅用于科学研究,不针对患者销售,望谅解.

产品详情

Doramapimod(BIRB 796)是p38 MAPK的小分子抑制剂,在调节促炎细胞因子的产生中起关键作用。
靶点信息
p38α (Cell-free assay) p38α
0.1 nM(Kd)38 nM
In vitro (25°C) DMSO 99 mg/mL (187.61 mM)
Water Insoluble
Ethanol 99 mg/mL (187.61 mM)
In vivo 5% DMSO+40%PEG300+5%Tween80??+50%H2O 4 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.95 mL 94.75 mL 189.5 mL
0.5 mM 3.79 mL 18.95 mL 37.9 mL
1 mM 1.9 mL 9.48 mL 18.95 mL
5 mM 0.38 mL 1.9 mL 3.79 mL

*The above data is based on the productmolecular weight 527.7 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

目录号 A10148
作用机制 Inhibitor (抑制剂)
M. Wt 527.7
Formula C31H37N5O3
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

CAS No. 285983-48-4
Synonyms BIRB-796,BIRB 796
SMILES CC1=CC=C(C=C1)N2C(=CC(=N2)C(C)(C)C)NC(=O)NC3=CC=C(C4=CC=CC=C43)OCCN5CCOCC5

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