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搜索结果：“ADM Hydrochloride”

“ADM Hydrochloride”的搜索结果

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Clomipramine HCl

Catalog No. A10231
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5-HT Receptor 激动剂

Clomipramine HCl是下列转运蛋白的阻滞剂：5-羟色胺转运蛋白 (SERT)(Ki = 0.14 nM)，去甲肾上腺素转运蛋白（NET）(Ki = 54 nM)，多巴胺转运蛋白（DAT）(Ki = 3，020 nM)，甘氨酸转运蛋白（GlyT/LeuT）。了解更多

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Dobutamine hydrochloride

Catalog No. A10325
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Adrenoceptors 激动剂

Dobutamine hydrochloride是一种直接作用剂，其主要活性来自刺激心脏的β1肾上腺素能受体，增加收缩力和心输出量。了解更多

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Rotigotine HCl

Catalog No. A11118
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Dopamine Receptor 激动剂

Rotigotine hydrochloride是一种多巴胺D2和D3受体激动剂。D2和D3的Ki值分别为13和0.71 nM。了解更多

Product Citations (2)

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- Mattia Ferraiolo, .et al. Dopamine D2L receptor density influences the recruitment of β-arrestin2 and Gi1 induced by antiparkinsonian drugs, Neuropharmacology, 2022, 207: 108942
- Mattia Ferraiolo, .et al. Receptor density influences ligand-induced dopamine D 2L receptor homodimerization, Eur J Pharmacol, 2021, Nov 15;911:174557 PMID: 34626593
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Phenylephrine HCl

Catalog No. A11666
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α1-adrenergic receptor 激动剂

Phenylephrine HCl是一种选择性的α1肾上腺素能受体激动剂，主要用作减充血剂，扩张瞳孔和增加血压的药物。了解更多

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Guanfacine hydrochloride

Catalog No. A15098
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α2A-adrenoceptor 激动剂

Guanfacine hydrochloride是一种抗高血压药，是一种选择性的α2A肾上腺素受体激动剂，Kd为31 nM，选择性是α2B肾上腺素受体的60倍。了解更多

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Dexmedetomidine HCl

Catalog No. A11846
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alpha2-adrenoceptor 激动剂

Dexmedetomidine hydrochloride是美托咪啶的活性异构体，它充当有效的，高度选择性的α2-AR（α2-肾上腺素受体）激动剂。了解更多

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MCOPPB 3HCl

Catalog No. A10561
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NOP receptor 激动剂

MCOPPB 3HCl是一种用作伤害感受器受体的有效和选择性激动剂的化合物，pKi为10.07。了解更多

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Nalfurafine hydrochloride

Catalog No. A12579
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opioid κ-selective 激动剂

Nalfurafine hydrochloride是一种κ-opioid激动剂。了解更多

Product Citations (6)

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- Alexander R French, .et al. Sex- and β-arrestin-dependent effects of kappa opioid receptor-mediated ethanol consumption, Pharmacol Biochem Behav, 2022, May;216:173377 PMID: 35364122
- Wen-Wen Zhang, .et al. Peripheral ablation of type III adenylyl cyclase induces hyperalgesia and eliminates KOR-mediated analgesia in mice, JCI Insight, 2022, Feb 8;7(3):e153191 PMID: 34914639
- A Dunn, .et al. Modulation of Cocaine-Related Behaviors by Low Doses of the Potent KOR Agonist Nalfurafine in Male C57BL6 Mice, Psychopharmacology (Berl), 2020, May 20 PMID: 32435819
- Dunn AD, .et al. Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses, ACS Chem Neurosci, 2019, Aug 21;10(8):3590-3600 PMID: 31313902
- Anika Mann, .et al. Agonist-selective NOP receptor phosphorylation correlates in vitro and in vivo and reveals differential post-activation signaling by chemically diverse agonists, Sci Signal, 2019, Mar 26;12(574). pii: eaau8072 PMID: 30914485
- Snyder LM, .et al. Kappa Opioid Receptor Distribution and Function in Primary Afferents, Neuron, 2018, Sep 19;99(6):1274-1288.e6 PMID: 30236284
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Nalmefene hydrochloride

Catalog No. A13843
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dopamine receptor 激动剂

Nalmefene hydrochloride是opioid receptor拮抗剂。了解更多

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- Mark G Papich, .et al. Naloxone and nalmefene absorption delivered by hollow microneedles compared to intramuscular injection, Drug Deliv Transl Res, 2022, Feb;12(2):376-383 PMID: 34817831
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lorcaserin hydrochloride (APD-356)

Catalog No. A12598
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serotonin 2C receptor 激动剂

lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂，可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。了解更多

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- Li Li, .et al. Delineating a serotonin 1B receptor circuit for appetite suppression in mice, J Exp Med, 2022, Aug 1;219(8):e20212307 PMID: 35796804
- Henrik H. Hansen, .et al. Whole-brain activation signatures of weight-lowering drugs, Mol Metab, 2021, May;47:101171 PMID: 33529728