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搜索结果：“jwh 250”

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PSI-7409

Catalog No. A13962
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nucleotide analog HCV inhibitor

PSI-7409 is the active 5'-triphosphate metabolite of Sofosbuvir (PSI-7977). Sofosbuvir (PSI-7977) is a selective and highly active nucleotide analog inhibitor of HCV. 了解更多

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Simeprevir

Catalog No. A11580
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HCV NS3/4A protease 抑制剂

Simeprevir是HCV NS3/4A蛋白酶（Ki = 0.36 nM）和病毒复制（replicon EC50 = 7.8 nM）的有效抑制剂。了解更多

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Nelfinavir

Catalog No. A11504
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HIV-1 protease 抑制剂

Nelfinavir是一种有效的口服生物可利用的人类免疫缺陷病毒HIV-1蛋白酶抑制剂(Ki=2 nM ),广泛用于与HIV逆转录酶抑制剂联合治疗HIV感染。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
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Enfuvirtide Acetate(T-20)

Catalog No. A15825
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HIV fusion 抑制剂

Enfuvirtide Acetate (T-20)是一个36个氨基酸的肽段，对应于gp41（HIV-1包膜蛋白的跨膜亚基）区域。了解更多

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GS-7340

Catalog No. A15772
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NRT 抑制剂

GS-7340是替诺福韦（TFV）的前药，它比TFV富马酸二甲酚更有效地将TFV输送到淋巴样细胞和组织中。了解更多

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VCH-759

Catalog No. A15479
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HCV Polymerase 抑制剂

VCH-759是HCV RNA依赖性聚合酶的非核苷抑制剂，相对于基因型1a/1b复制子，具有亚微摩尔IC50值。了解更多

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- Hassan GS, .et al. Anti-hepatitis-C virus activity and QSAR study of certain thiazolidinone and thiazolotriazine derivatives as potential NS5B polymerase inhibitors, Eur J Med Chem, 2019, Oct 1;184:111747 PMID: 31604164
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MK-5172 sodium salt

Catalog No. A15168
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HCV Protease 抑制剂

MK-5172 sodium salt是目前正在临床开发中的新型P2-P4喹喔啉大环HCV NS3/4a蛋白酶抑制剂。了解更多

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Fosamprenavir Calcium Salt

Catalog No. A15089
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HIV protease 抑制剂

Fosamprenavir Calcium Salt 是抗逆转录病毒蛋白酶抑制剂amprenavir的磷酸酯前药，与母体分子相比具有更高的溶解度，并有可能减轻当前给药方案中的药丸负担；GW433908G是前药的钙盐。了解更多

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BI207127 (Deleobuvir)

Catalog No. A13414
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HCV NS5B polymerase 抑制剂

BI 207127是非核苷类丙型肝炎病毒NS5B聚合酶抑制剂，用于治疗丙型肝炎。了解更多

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Cenicriviroc

Catalog No. A13643
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CCR2/CCR5 抑制剂

Cenicriviroc是用于治疗HIV感染的实验性候选药物.Cenicriviroc是CCR2和CCR5受体的抑制剂，可使其充当阻止病毒进入人体细胞的进入抑制剂。了解更多

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Bevirimat

Catalog No. A14194
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HIV-1 maturation 抑制剂

Bevirimat (PA-457,MPC-4326,YK FH312) 是HIV-1病毒颗粒成熟抑制剂。了解更多

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- Mingzhang Wang, .et al. Quenching protein dynamics interferes with HIV capsid maturation, Nat Commun, 2017, 8: 1779 PMID: 29176596
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Fosamprenavir

Catalog No. A12583
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HIV protease 抑制剂

Fosamprenavir是amprenavir的前药，amprenavir是人类免疫缺陷病毒（HIV）蛋白酶的抑制剂。了解更多

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Ledipasvir (GS 5885)

Catalog No. A13155
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NS5A 抑制剂

Ledipasvir (GS 5885)是丙型肝炎病毒HCV NS5A蛋白的抑制剂。了解更多

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- Sayuri Nitta, .et al. Impact of novel NS5A resistance-associated substitutions of hepatitis C virus detected in treatment-experienced patients, Scientific Reports, 2019, 9: 5722 PMID: 30952914
- Miyayama Y, .et al. Comparative study on the replication of HCV1b genome between wild type and cell culture adaptive mutant in regard to sensitivities against anti-HCV drugs, Microbiol Immunol, 2019, Dec 19 PMID: 31854467
- Sayuri Nitta, .et al. Effects of Resistance-Associated NS5A Mutations in Hepatitis C Virus on Viral Production and Susceptibility to Antiviral Reagents, Sci Rep, 2016, 6: 34652 PMID: 27703205
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Saquinavir

Catalog No. A11378
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HIV Protease 抑制剂

Saquinavir是蛋白酶抑制剂。蛋白酶是将蛋白质分子切割成更小片段的酶。Saquinavir抑制HIV-1和HIV-2蛋白酶。了解更多

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
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Abacavir

Catalog No. A11115
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Transcriptase 抑制剂

Abacavir是一种核苷类似物逆转录酶抑制剂（NRTI）；鸟苷类似物用于治疗艾滋病毒和艾滋病。了解更多

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Abacavir sulfate

Catalog No. A11120
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Transcriptase 抑制剂

Abacavir sulfate是一种核苷类似物逆转录酶抑制剂（NRTI）。了解更多

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Peramivir

Catalog No. A11124
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Neuraminidase 抑制剂

Peramivir是一种神经氨酸酶抑制剂，可作为流感神经氨酸酶的过渡态类似物抑制剂，从而防止新病毒从受感染的细胞中出现。了解更多

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- Daisuke Kato, .et al. An easy, rapid, and sensitive method for detection of drug-resistant influenza virus by using a sialidase fluorescent imaging probe, BTP3-Neu5Ac, PLoS One, 2018, 13(7): e0200761 PMID: 30001430
- Yuuki Kurebayashi, .et al. High-Efficiency Capture of Drug Resistant-Influenza Virus by Live Imaging of Sialidase Activity, PLoS One, 2016, 11(5): e0156400 PMID: 27232333
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BMS-707035

Catalog No. A10156
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HIV-1 integrase 抑制剂

BMS-707035是HIV-1整合酶（IN）抑制剂。HIV-1整合酶（IN）代表临床上治疗HIV/AIDS的具有治疗优势的病毒靶标。了解更多

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S/GSK1349572 (Dolutegravir)

Catalog No. A11068
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HIV integrase 抑制剂

S/GSK1349572是有效的下一代HIV整合酶抑制剂，并通过60个整合酶突变分子克隆证实了优异的耐药性。了解更多

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- Lea El Khoury, .et al. Spectrometric and computational studies of the binding of HIV-1 integrase inhibitors to viral DNA extremities, PeerJ Preprints, 2019, 7:e27833v1
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Delavirdine mesylate

Catalog No. A13274
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NNRT 抑制剂

Delavirdine是一种有效的人类免疫缺陷病毒1型（HIV-1）逆转录酶（RT）抑制剂。了解更多

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