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CK-666

Catalog No. A20973
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Arp2/3 complex inhibitor

CK-666 is a cell-permeable inhibitor of actin-related protein Arp2/3 complex, and binds to Arp2/3 complex, stabilizes the inactive state of the complex, blocking movement of the Arp2 and Arp3 subunits into the activated filament-like (short pitch) conformation. 了解更多

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Carotegrast

Catalog No. A21997
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α4 integrin receptor inhibitor

Carotegrast is an orally available α4 integrin receptor inhibitor with anti-inflammatories activities. 了解更多

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Cabazitaxel

Catalog No. A11831
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Microtubule Associated 抑制剂

Cabazitaxel是一种天然紫杉烷的半合成衍生物。Cabazitaxel联合泼尼松是基于多西他赛的激素难治性前列腺癌的治疗选择。了解更多

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- Satoshi Endo, .et al. Targeting Nrf2-antioxidant signaling reverses acquired cabazitaxel resistance in prostate cancer cells, J Biochem, 2021, Mar 17 PMID: 33729485
- Tomohiro Nabekura, .et al. Microtubule-targeting anticancer drug eribulin induces drug efflux transporter P-glycoprotein, Biochem Biophys Rep, 2020, Mar; 21: 100727 PMID: 31993509
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Ixabepilone

Catalog No. A11449
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microtubule 抑制剂

Ixabepilone是epothilone B类似物。了解更多

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- Dong-Sheng Cao, .et al. A Multi-Scale Systems Pharmacology Approach Uncovers the Anti-Cancer Molecular Mechanism of Ixabepilone, Eur J Med Chem, 2020, Aug 1;199:112421 PMID: 32428794
- Hoque M, .et al. Changes in cell morphology guide identification of tubulin as the off-target for protein kinase inhibitors, Pharmacol Res, 2018, Aug;134:166-178 PMID: 29944980
- APRIL L. RISINGER, .et al. Breast Cancer Cell Lines Exhibit Differential Sensitivities to Microtubule-targeting Drugs Independent of Doubling Time, Anticancer Res, 2015, Nov; 35(11): 5845-5850. PMID: 26504006
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ABT-751 (E-7010)

Catalog No. A10024
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Microtubule Associated 抑制剂

ABT-751 (E-7010)是一种抗有丝分裂剂，可抑制微管聚合，并在秋水仙碱位点与β-微管蛋白结合。在G2M期阻断细胞周期并诱导凋亡。了解更多

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