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搜索结果：“AZ 960”

“AZ 960”的搜索结果

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Omeprazole

Catalog No. A10672
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ATPase 抑制剂

Omeprazole是一种可透过细胞的选择性质子泵抑制剂。了解更多

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AZD-3965

Catalog No. A14186
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MCT1 抑制剂

AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。了解更多

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- Lu Gao, .et al. Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy, Int J Biol Sci, 2022, Jan 1;18(2):599-616 PMID: 35002512
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Tenatoprazole

Catalog No. A14272
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proton pump 抑制剂

Tenatoprazole是质子泵抑制剂（PPI）类的前药，可抑制质子转运，IC50为3.2 uM。了解更多

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Oxcarbazepine

Catalog No. A13943
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sodium channel protein 抑制剂

Oxcarbazepine是一种钠通道蛋白抑制剂。了解更多

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Cyclothiazide

Catalog No. A13700
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AMPA desensitization 抑制剂

Cyclothiazide是苯并噻二叠氮，可作为AMPA受体的增效剂，正向调节其对谷氨酸的响应（EC50 = 3.8 M）。了解更多

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Cyclopiazonic Acid

Catalog No. A14002
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SERCA 抑制剂

Cyclopiazonic acid是SERCA（内质网Ca2+ -ATPase）的抑制剂，可诱导细胞内储存的Ca2+释放，而不会增加IP3水平。了解更多

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Tenapanor

Catalog No. A14011
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NHE3 抑制剂

Tenapanor充当钠-质子交换器NHE3的抑制剂。这种抗转运蛋白在肾脏和肠道中发现，通常起到调节机体吸收和分泌的钠水平的作用。了解更多

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- Xingjie Tan, .et al. The Na+/H+ exchanger NHE3 inhibitor tenapanor prevents intestinal obstructions in CFTR-deleted mice, Authorea, 2022, May 25
- Kunyan Zhou, .et al. Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells, Am J Physiol Cell Physiol, 2021, Sep 1;321(3):C471-C488 PMID: 34288721
- Qinghai Tan, .et al. Inhibition of Na + /H + exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator-deficient and F508del mutant mice, Br J Pharmacol, 2021, Mar;178(5):1018-1036 PMID: 33179259
- Y Liu, .et al. Deciphering Ion Transporters, Kinases and PDZ-adaptor Molecules That Mediate Guanylate Cyclase C Agonist-Dependent Intestinal Fluid Loss in Vivo, Biochem Pharmacol, 2020, May 16;178:114040 PMID: 32422138
- Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
- Thammayon N, .et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 PMID: 27981415
- Charoenphandhu N, .et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 PMID: 27995414
- Jantarajit W, .et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 PMID: 28490422
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Esomeprazole Magnesium trihydrate

Catalog No. A15082
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Proton pump 抑制剂

Esomeprazole Magnesium trihydrate 是质子泵抑制剂，可通过抑制胃壁细胞中的H+/K+ ATPase来减少酸的分泌。了解更多

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Azaphen dihydrochloride monohydrate

Catalog No. A15009
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serotonin reuptake 抑制剂

Azaphen dihydrochloride monohydrate是5-羟色胺再摄取的有效抑制剂。了解更多

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Esomeprazole sodium

Catalog No. A10365
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Proton pump 抑制剂

Esomeprazole sodium是一种质子泵抑制剂，可通过抑制胃壁细胞中的H+/K+ ATPase来减少酸的分泌。了解更多

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Rebeprazole sodium

Catalog No. A16147
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proton pump 抑制剂

Rebeprazole sodium是质子泵抑制剂中的一种抗溃疡药。了解更多

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Valbenazine

Catalog No. A16206
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VMAT2 抑制剂

Valbenazine是一种有效的选择性VMAT2抑制剂。了解更多

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Dapagliflozin impurity

Catalog No. A19103
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SGLT2 抑制剂

Dapagliflozin impurity is an enantiomer of Dapagliflozin which is a sodium-glucose transporter 2 inhibitor. 了解更多

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TRPC6-IN-1

Catalog No. A12309
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TRPC6 inhibitor

TRPC6-IN-1 is a Transient Receptor Potential Canonical 6 Channel (TRPC6) inhibitor, with an EC50 of 4.66 μM. 了解更多

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TTT-28

Catalog No. A13033
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ABCB1 (P-gp/MDR1) inhibitor

TTT-28 is a synthesized thiazole-valine peptidomimetic, a novel selective inhibitor of ABCB1 (P-gp/MDR1) with high efficacy and low toxicity. 了解更多

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P-gp inhibitor 1

Catalog No. A13384
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P-gp inhibitor

P-gp inhibitor 1 is a novel inhibitor reversing P-glycoprotein-mediated multidrug resistance. 了解更多

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Nav1.7-IN-3

Catalog No. A13626
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voltage-gated sodium channel Nav1.7 inhibitor

Nav1.7-IN-3 is a selective, orally bioavailable voltage-gated sodium channel Nav1.7 inhibitor with an IC50 of 8 nM. Pain relief. Limited CNS penetration. 了解更多

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Funapide

Catalog No. A21298
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Sodium Channel Nav1.7 inhibitor

Funapide (TV 45070; XEN402) is a potent Sodium Channel Nav1.7 inhibitor. 了解更多

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Leptomycin B

Catalog No. A20985
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nuclear export receptor CRM1 inhibitor

Leptomycin B (CI 940; LMB) is a potent inhibitor of the nuclear export of proteins. Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue. Leptomycin B is a potent antifungal antibiotic blocking the eukaryotic cell cycle. 了解更多

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MK-7145

Catalog No. A21030
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ROMK inhibitor

MK-7145 is a ROMK inhibitor, with an IC50 of 0.045 μM. 了解更多

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CFTRinh-172

Catalog No. A12897
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CFTR 抑制剂

CFTRinh-172是电压无关的选择性CFTR抑制剂。在2分钟内可逆地抑制CFTR短路电流的 Ki 值为300 nM。了解更多

Product Citations (1)

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- Dao-Lai Zhang, .et al. Gq activity- and β-arrestin-1 scaffolding-mediated ADGRG2/CFTR coupling are required for male fertility, eLife, 2018, 7: e33432 PMID: 29393851

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