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DZNep

Catalog No. A11377
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EZH2 抑制剂

3 Deazaneplanocin A(DZNep)是3-deazaadenosine的环戊烯基类似物，最初是作为S-腺苷L-homocysteine水解酶的抑制剂合成的。了解更多

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EPZ-6438 (Tazemetostat)

Catalog No. A12712
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EZH2 抑制剂

EPZ-6438 (Tazemetostat)是一种有效的，选择性的，口服可利用的EZH2酶促活性小分子抑制剂，无细胞试验中Ki 和 IC50分别为2.5 nM 和 11 nM。它诱导SMARCB1缺失的MRT细胞中的凋亡和分化。了解更多

Product Citations (3)

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- Wang Z, .et al. Targeting EZH 2 as a novel therapeutic strategy for sorafenib‐resistant thyroid carcinoma, J Cell Mol Med, 2019, May 13 PMID: 31087496
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Theresa Baker, .et al. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors, Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609
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3-deazaneplanocin A HCl (DZNep HCl)

Catalog No. A13947
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EZH2 抑制剂

3-deazaneplanocin A，也称为DZNep，是众所周知的组蛋白甲基转移酶抑制剂，可破坏包括急性髓样白血病，乳腺癌在内的癌细胞中的多梳抑制复合物2（PRC2），并诱导细胞凋亡，同时抑制增殖和转移。癌症和胶质母细胞瘤。了解更多

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