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INH14

Catalog No. A19119
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IKKα/IKKβ inhibitor

INH14 is a cell permeable inhibitor of IKKα/IKKβ, with IC50s of 8.97 and 3.59 μM, respectively. 了解更多

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Episilvestrol

Catalog No. A15080
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Apoptosis inducer

Episilvestrol是Silvestrol的衍生物，它可以通过线粒体/凋亡途径在LNCaP细胞中诱导凋亡，而不会激活执行子caspase-3或-7。5'myc-UTR-LUC抑制剂（IC50 = 0.8 nM）。了解更多

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Lenalidomide (CC-5013)

Catalog No. A10522
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Ubiquitin ligase inducer

Lenalidomide (CC-5013)是Thalidomide的衍生物。在体外，Lenalidomide具有三种主要活性:直接抗肿瘤作用、抑制肿瘤细胞的微环境支持和免疫调节作用。它通过抑制骨髓基质细胞支持、抗血管生成和抗破骨细胞生成作用以及免疫调节活性直接和间接诱导肿瘤细胞凋亡。了解更多

Product Citations (4)

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- Daniel A. Rauch, .et al. Interferon regulatory factor 4 as a therapeutic target in adult T-cell leukemia lymphoma, Retrovirology, 2020, 17: 27 PMID: 32859220
- A Hayano, .et al. Cell-type-specific sensitivity of bortezomib in the methotrexate-resistant primary central nervous system lymphoma cells, Int J Clin Oncol, 2019, 1-10 PMID: 30993483
- Kumar R, .et al. Novel combination of tanshinone I and lenalidomide induces chemo-sensitivity in myeloma cells by modulating telomerase activity and expression of shelterin complex and its associated molecules, Mol Biol Rep, 2018, Oct 11 PMID: 30311125
- Hirosumi Tamura, .et al. Evaluation of anticancer agents using patient-derived tumor organoids characteristically similar to source tissues, Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168