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搜索结果：“AZ 960”

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EPZ-6438 (Tazemetostat)

Catalog No. A12712
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EZH2 抑制剂

EPZ-6438 (Tazemetostat)是一种有效的，选择性的，口服可利用的EZH2酶促活性小分子抑制剂，无细胞试验中Ki 和 IC50分别为2.5 nM 和 11 nM。它诱导SMARCB1缺失的MRT细胞中的凋亡和分化。了解更多

Product Citations (3)

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- Wang Z, .et al. Targeting EZH 2 as a novel therapeutic strategy for sorafenib‐resistant thyroid carcinoma, J Cell Mol Med, 2019, May 13 PMID: 31087496
- Yang PM, .et al. p38α/S1P/SREBP2 activation by the SAM-competitive EZH2 inhibitor GSK343 limits its anticancer activity but creates a druggable vulnerability in hepatocellular carcinoma, Am J Cancer Res, 2019, Oct 1;9(10):2120-2139 PMID: 31720078
- Theresa Baker, .et al. Acquisition of a single EZH2 D1 domain mutation confers acquired resistance to EZH2-targeted inhibitors, Oncotarget, 2015, Oct 20; 6(32): 32646-32655 PMID: 26360609

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