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AZD5153 6-Hydroxy-2-naphthoic acid

Catalog No. A21852
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BET/BRD4 bromodomain inhibitor

AZD5153 6-Hydroxy-2-naphthoic acid is the 6-Hydroxy-2-naphthoic acid of AZD5153. AZD5153 is a potent, selective, and orally available BET/BRD4 bromodomain inhibitor; disrupts BRD4 with an IC50 of 1.7 nM. 了解更多

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GS-626510

Catalog No. A13305
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BET family bromodomains inhibitor

GS-626510 is a potent, and orally bioavailable BET family bromodomains inhibitor, with Kd values of 0.59-3.2 nM for BRD2/3/4, with IC50 values of 83 nM and 78 nM foe BD1 and BD2, respectively. 了解更多

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CD235

Catalog No. A19115
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BET bromodomain inhibitor

CD235 is a structurally similar analogue of CD161. CD161 is a potent and orally bioavailable BET bromodomain inhibitor. 了解更多

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GNE-207

Catalog No. A18844
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CBP bromodomain inhibitor

GNE-207 is a novel, potent, and orally bioavailable inhibitor of the bromodomain of CBP. GNE-207 has excellent CBP potency (CBP IC50?=?1?nM, MYC EC50?=?18?nM), and it exhibits a good pharmacokinetic profile. 了解更多

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Mivebresib (ABBV-075)

Catalog No. A17226
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BET inhibitor

Mivebresib, also known as ABBV-075, is a potent BET inhibitor (bromodomain (BRD)-containing proteind) with potential antineoplastic activity. 了解更多

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ABBV-744

Catalog No. A16831
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BET bromodomain 抑制剂

ABBV-744是一种BDII选择性BET溴结构域抑制剂，正在研究中，用于治疗AML和对去势抵抗的前列腺癌。了解更多

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Apabetalone (RVX-208)

Catalog No. A13956
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BET bromodomain 抑制剂

RVX-208是一种有效的BET溴结构域抑制剂，对BD2的IC50为0.510 uM，是BD1选择性的170倍。了解更多

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