“betaine hydrochloride”的搜索结果
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PARP1 and PARP2 inhibitor
Niraparib hydrochloride (MK-4827 hydrochloride) is a highly potent and orally bioavailable PARP1 and PARP2 inhibitor with IC50s of 3.8 and 2.1 nM, respectively.
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HDAC 抑制剂
Resminostat hydrochloride是HDAC1/3/6的有效抑制剂(IC50 = 43-72 nM);对HDAC8的效力较低,IC50为877 nM。
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HDAC inhibitor
Givinostat hydrochloride (ITF-2357 hydrochloride) is a HDAC inhibitor with an IC50 of 198 and 157 nM for HDAC1 and HDAC3, respectively.
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Pim 抑制剂
CX-6258 hydrochloride hydrate是一种有效的,口服有效的Pim 1/2/3激酶(IC50 = 5 nM/25 nM/16 nM)抑制剂,具有出色的生化效能和激酶选择性。
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Aurora inhibitor
SCH-1473759 hydrochloride is an aurora inhibitor with IC50s of 4 and 13 nM for aurora A and B, respectively.
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SIRT1 activator of
SRT 1720 Hydrochloride is a selective activator of SIRT1 with an EC50 of 0.10 μM, and shows less potent activities on SIRT2 and SIRT3.
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JAK2 抑制剂
NS-018 hydrochloride是一种新型的高选择性JAK2抑制剂。
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PARP 抑制剂
PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。
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- Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
- Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
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LSD1 inhibitor
T-3775440 (hydrochloride) is an irreversible lysine-specific histone demethylase (LSD1) inhibitor with an IC50 value of 2.1 nM.
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LSD1/BHC110 & MAO 抑制剂
Tranylcypromine hydrochloride是一种非选择性的MAO-A/B抑制剂。
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PARP inhibitor
Veliparib dihydrochloride is a potent PARP inhibitor, inhibiting PARP1 and PARP2 with Kis of 5.2 and 2.9 nM, respectively.
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LSD1 inhibitor
GSK-LSD1 dihydrochloride is a potent, selective and irreversible lysine specific demethylase 1 (LSD1) inhibitor with an IC50 of 16 nM.
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JAK2 inhibitor
NVP-BSK805 dihydrochloride (BSK805 dihydrochloride) is an ATP-competitive JAK2 inhibitor, with IC50s of 0.48 nM, 31.63 nM, 18.68 nM, and 10.76 nM for JAK2 JH1 (JAK homology 1), JAK1 JH1, JAK3 JH1, and TYK2 JH1, respectively.
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Amodiaquine dihydrochloride dihydrate是人红细胞中组胺N-甲基转移酶的有效,非竞争性抑制剂,也用作抗疟疾和抗炎药。
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PRMT5 抑制剂
HLCL-61 hydrochloride是一种有效的选择性PRMT5抑制剂,可用于治疗急性髓细胞性白血病。
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MBT Domain (L3MBTL1) 抑制剂
UNC 926 hydrochloride是甲基赖氨酸阅读器域抑制剂。
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