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Ferroptosis inhibitor
RSL3 is a ferroptosis activator in a VDAC-independent manner,exhibiting selectivity for tumor cells bearing oncogenic RAS.
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- Sampilvanjil A, .et al. Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells, Am J Physiol Heart Circ Physiol, 2020, Mar 1;318(3):H508-H518 PMID: 31975626
- Fujiki K, .et al. Blockade of ALK4/5 signaling suppresses cadmium- and erastin-induced cell death in renal proximal tubular epithelial cells via distinct signaling mechanisms, Cell Death Differ, 2019, Feb 25 PMID: 30804470
- Samantha W. Alvarez, .et al. NFS1 undergoes positive selection in lung tumours and protects cells from ferroptosis, Nature, 2017, Nov 30; 551(7682): 639-643 PMID: 29168506