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47 个项目
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Seviteronel
Catalog No. A20996 CYP17 lyase inhibitorSeviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多 -
Liarozole dihydrochloride
Catalog No. A21853 CYP450 dependent inhibitorLiarozole dihydrochloride (R75251; R85246) is a cytochrome P450 (CYP450) dependent inhibitor, orally active, it also a potent inhibitor of estrogen (via inhibition of aromatase) and testicular androgen synthesis (inhibition of 17 ,20-lyase). 了解更多 -
VP3.15 dihydrobromide
Catalog No. A21789 PDE7/GSK3 inhibitorVP3.15 dihydrobromide is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. 了解更多 -
RGX-104 free Acid
Catalog No. A21513 LXR agonistRGX-104 free Acid is an orally bioavailable and potent liver-X nuclear hormone receptor (LXR) agonist that modulates innate immunity via transcriptional activation of the ApoE gene. 了解更多 -
Mutant IDH1-IN-2
Catalog No. A21339 IDH inhibitorMutant IDH1-IN-2 is a inhibitor of mutant Isocitrate dehydrogenase (IDH) proteins, with IC50 of in LS-MS biochemical assay, IC50 of 16.6 nM in Fluorescence biochemical assay. 了解更多 -
PDE-9 inhibitor
Catalog No. A11532 -
GNF-PF-3777
Catalog No. A13507 hIDO2 inhibitorGNF-PF-3777 (8-Nitrotryptanthrin) is a potent human indoleamine 2,3-dioxygenase 2 (hIDO2) inhibitor which significantly reduces IDO2 activity with Ki of 0.97 μM. 了解更多 -
SBI-797812
Catalog No. A19058 NAMPT activatorSBI-797812 is a novel NAMPT activator, elevating liver NAD+, turning NAMPT into a "super catalyst" that more efficiently generates NMN. 了解更多 -
Mutant IDH1-IN-4
Catalog No. A19106 IDH1 inhibitorMutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells. 了解更多 -
VP3.15
Catalog No. A18538 dual PDE7/GSK-3 inhibitorVP3.15 is a potent, orally bioavailable and CNS-penetrant dual phosphodiesterase (PDE)7- glycogen synthase kinase (GSK)3 inhibitor, with IC50s of 1.59 μM and 0.88 μM for PDE7 and GSK-3, respectively. VP3.15 has neuroprotective and neuroreparative activities, thus as potential combined anti-inflammatory and pro-remyelinating therapies for multiple sclerosis (MS). 了解更多 -
IDO/TDO-IN-1
Catalog No. A18566 IDO/TDO dual inhibitorIDO/TDO-IN-1 is a highly potent and orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor with IC50s of 9.7 and 47 nM, respectively . 了解更多 -
Olutasidenib (FT-2102)
Catalog No. A18789 IDH1 inhibitorOlutasidenib is a potent, selective inhibitor of mutant Isocitrate dehydrogenase (IDH)1 for the treatment of acute myeloid leukemia. 了解更多 -
Iproniazid phosphate
Catalog No. A18135 MAO inhibitorIproniazid phosphate is an irreversible inhibitor of monoamine oxidase types A and B that is used as an antidepressive agent. It has also been used as an antitubercular agent, but its use is limited by its toxicity. 了解更多 -
Iproniazid
Catalog No. A17445 MAO inhibitorIproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor (MAOI) that is used as an antidepressive agent. 了解更多 -
Sulfaphenazole
Catalog No. A17283 CYP2C9 inhibitorSulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. 了解更多 -
Timegadine
Catalog No. A17108 COX and lipo-oxygenase 抑制剂Timegadine被发现是一种有效的竞争性环加氧酶（COX）和脂加氧酶抑制剂，IC50的范围从5 nM（洗兔血小板）到20μM（大鼠脑）。在马血小板匀浆的细胞溶质级分和洗涤过的兔血小板中，脂氧化酶的浓度为100μM和100μM。 了解更多 -
Fomepizole
Catalog No. A16164 -
AG-120
Catalog No. A15869 -
Nordihydroguaiaretic acid
Catalog No. A15190 lipoxygenase 抑制剂Nordihydroguaiaretic acid是从杂酚丛生的Larrea divaricata中分离出来的天然酚类化合物，在体外和体内均具有抗肿瘤活性。其类似物正在临床开发中，用于难治性实体瘤。 了解更多 -
6,7-Dihydroxycoumarin
Catalog No. A14553 -
Collagen proline hydroxylase inhibitor
Catalog No. A11371 -
Piperlongumine
Catalog No. A14124 TrxR1/CRM1 抑制剂Piperlongumine，存在于胡椒科植物荜茇中的一种天然生物碱，能够增加reactive oxygen species (ROS)水平，并选择性杀死癌细胞。它还是TrxR1的直接抑制剂，对胃癌具有抑制活性；一种新型的CRM1抑制剂；在人类乳腺癌细胞中可抑制PI3K/Akt/mTOR。 了解更多 -
StemRegenin 1 (SR1)
Catalog No. A12945 AhR 拮抗剂StemRegenin 1 (SR1)是一种细胞可渗透的嘌呤衍生物，作为芳香烃受体的拮抗剂，促进造血干细胞(HSC)的自我更新。 了解更多 -
TAK-700 Salt (Orteronel Salt)
Catalog No. A13515 CYP17A1/androgen synthesis 抑制剂TAK-700 Salt (Orteronel Salt)是一种雄激素合成抑制剂。它选择性地抑制在睾丸，肾上腺和前列腺肿瘤组织中表达的酶CYP17A。 了解更多 -
Tepoxalin
Catalog No. A12879 -
CPI-613 (Devimistat)
Catalog No. A11786 Dehydrogenase 抑制剂CPI-613是合成的α-硫辛酸硫辛酸类似物的对映异构体的外消旋混合物，具有潜在的化学预防和抗肿瘤活性。 了解更多 -
UK-383367
Catalog No. A10959 -
Leflunomide
Catalog No. A10521 Dehydrogenase 抑制剂Leflunomide是一种嘧啶合成抑制剂，属于DMARD类药物。来氟米特用于缓解类风湿性关节炎引起的症状，如炎症、肿胀、僵硬和关节痛。 了解更多 -
Cyproterone acetate
Catalog No. A11409 Androgen Receptor 拮抗剂Cyproterone acetate是17-羟孕酮的合成衍生物，可作为雄激素受体拮抗剂以及具有弱孕激素和糖皮质激素活性的弱孕激素受体激动剂。 了解更多 -
Naringenin
Catalog No. A10625 Naringenin是一种黄烷酮，是一种类黄酮，被认为具有抗氧化剂，自由基清除剂，消炎，碳水化合物代谢促进剂和免疫系统调节剂等对人体健康的生物活性。 了解更多 -
Decitabine
Catalog No. A10292 DNA Methyltransferase 抑制剂Decitabine是一种次甲基化剂，它通过抑制DNA甲基转移酶来使DNA次甲基化。 了解更多 -
Ammonium Glycyrrhizinate (AMGZ)
Catalog No. A10070
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- Cytochrome P450 (9)
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