“Tutalthromycin second gen”的搜索结果
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antineoplastic agent
Amsacrine hydrochloride (m-AMSA hydrochloride; acridinyl anisidide hydrochloride) is an inhibitor of topoisomerase II, and acts as an antineoplastic agent which can intercalates into the DNA of tumor cells.
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DNA polymerase IIIC 抑制剂
ACX-362E is an orally available DNA polymerase IIIC (pol IIIC) inhibitor, acts as an antimicrobial agent to treat Gram-positive infections, with a MIC50 of 2 μg/mL for C. difficile. ACX-362E displays very potent in vitro and in vivo activities against broad spectrum of C. difficile pathogens.
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GL1 synthase 抑制剂
Genz-123346 free base是GL1合酶的抑制剂,可阻止神经酰胺向GL1的转化。抑制GM1的IC50为14 nM。
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Glucocerebroside synthase 抑制剂
Eliglustat tartrate通常用作酒石酸盐,据信Eliglustat通过抑制葡萄糖基神经酰胺合酶起作用。
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- Zunke F, .et al. Reversible Conformational Conversion of α-Synuclein into Toxic Assemblies by Glucosylceramide, Neuron, 2018, Jan 3;97(1):92-107.e10 PMID: 29290548
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DNA alkylating agent
Melphalan是一种用于治疗多发性骨髓瘤的细胞毒性药物。甲氨蝶呤的苯胺衍生物。
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bi-functional alkylating agent
VAL-083是一种双功能烷基化剂;单层抑制U251和SF188细胞生长优于TMZ并引起细胞凋亡。
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Blasticidin S HCl是一种分离自gistreochromogenes链霉菌的核苷抗生素,并充当DNA和蛋白质合成抑制剂。
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topoisomerase 1 抑制剂
GENZ-644282是拓扑异构酶I的非喜树碱抑制剂,具有潜在的抗肿瘤活性。
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Genistin (Genistoside)是一种异黄酮,存在于许多饮食植物中,如大豆和葛根。显示出刺激体内雌激素依赖性乳腺癌细胞生长。
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- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347
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Antioxidant, antiangiogenic, antitumor agent
(-)-Epigallocatechin gallate是一种从绿茶中分离出来的强效抗氧化剂多酚类黄酮。
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- Wafa Dridi, .et al. Influence of polysaccharide concentration on polyphenol-polysaccharide interactions, Carbohydr Polym, 2021, 274:118670 PMID: 34702486
- A S D'Costa, .et al. Inhibition of starch digestion by flavonoids: Role of flavonoid-amylase binding kinetics, Food Chem, 2020, Oct 1;341(Pt 2):128256 PMID: 33035827
- Fenteany G, .et al. Multilevel structure-activity profiling reveals multiple green tea compound families that each modulate ubiquitin-activating enzyme and ubiquitination by a distinct mechanism, Sci Rep, 2019, Sep 5;9(1):12801 PMID: 31488855
- LiliSun, .et al. Comparative Effect of Black, Green, Oolong and White Tea Intake on Body Weight Gain and Bile Acid Metabolism, Nutrition, 2019, pii:S0899-9007(18)31140-7