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搜索结果：“angiotensin converting enzyme ace”

“angiotensin converting enzyme ace”的搜索结果

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TBB

Catalog No. A15257
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CK2 抑制剂

TBB是酪蛋白激酶2（CK2）的高选择性，ATP/GTP竞争性抑制剂，对大鼠肝脏和人重组CK2的IC50分别为0.9和1.6 uM。了解更多

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SKL2001

Catalog No. A16707
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Wnt/β-catenin agonist

SKL2001 is an agonist of the Wnt/β-catenin pathway, with anti-cancer activity. SKL2001 stabilizes intracellular β-catenin via disruption of the Axin/β-catenin interaction. 了解更多

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Begacestat (GSI-953)

Catalog No. A11258
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γ-secretase 抑制剂

Begacestat (GSI-953)是一种新型的选择性淀粉样前体蛋白γ-分泌酶的噻吩磺酰胺抑制剂。了解更多

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BIO-acetoxime

Catalog No. A15555
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GSK-3 抑制剂

BIO-acetoxime是一种有效的双重GSK3α/β抑制剂，IC50为10 nM，选择性比CDK5/p25，CDK2/cyclin A和 CDK1/cyclin B高240倍以上。了解更多

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LY2811376

Catalog No. A11776
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BACE1 抑制剂

LY2811376是第一种可口服的非肽类BACE1抑制剂，可在动物体内产生显着的Aβ降低作用。了解更多

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Semagacestat (LY450139)

Catalog No. A10836
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Gamma-secretase 抑制剂

Semagacestat (LY450139)是一种针对Aβ42，Aβ40和Aβ38的γ-分泌酶阻滞剂，IC50分别为10.9 nM，12.1 nM和12.0 nM。 Semagacestat还抑制Notch信号传导，IC50为14.1 nM。了解更多

Product Citations (1)

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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
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BMS-708163 (Avagacestat)

Catalog No. A10157
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Gamma-secretase 抑制剂

BMS-708163 (Avagacestat)是口服生物有效的，选择性的γ-分泌酶抑制剂，作用于Aβ40和Aβ42时，IC50分别为0.3 nM和0.27 nM。了解更多

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