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Tofacitinib

Catalog No. A17252
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JAK3/2/1 inhibitor

Tofacitinib is an orally available JAK3/2/1 inhibitor with IC50s of 1, 20, and 112 nM, respectively. 了解更多

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- Aya Hasan Alshammari, .et al. Discrimination of hand-foot skin reaction caused by tyrosine kinase inhibitors based on direct keratinocyte toxicity and vascular endothelial growth factor receptor-2 inhibition, Biochem Pharmacol, 2022, Mar;197:114914 PMID: 35041812
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Upadacitinib (ABT-494)

Catalog No. A18316
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JAK-1 抑制剂

Upadacitinib (ABT-494) is a potent and selective Janus kinase (JAK) 1 inhibitor being developed for the treatment of several autoimmune disorders with an IC50 of 43 nM. IC50 & Target: IC50: 43 nM (JAK1), 200 nM (JAK2) 了解更多

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Abrocitinib (PF-04965842)

Catalog No. A18318
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JAK1 抑制剂

Abrocitinib (PF-04965842) is a potent, orally active and selective JAK1 inhibitor, with IC50s of 29 and 803 nM for JAK1 and JAK2, respectively. Abrocitinib (PF-04965842) exhibits less active effect on TYK2 (IC50, 1.253 μM), and inhibits phosphorylation of STAT1, STAT3 and STAT5 after stimulation. Effective in autoimmune disease. 了解更多

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1,2,3,4,5,6-Hexabromocyclohexane

Catalog No. A15361
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JAK2 抑制剂

1,2,3,4,5,6-Hexabromocyclohexane是一种有效且特异性的JAK2自磷酸化抑制剂。了解更多

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