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AZD-3965

Catalog No. A14186
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MCT1 抑制剂

AZD-3965（AZD3965）是具有1.6 nM结合亲和力的单羧酸盐转运蛋白1（MCT1）的选择性抑制剂，是MCT2的6倍选择性，在10μM时不抑制MCT4。了解更多

Product Citations (1)

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- Lu Gao, .et al. Trophoblast-derived Lactic Acid Orchestrates Decidual Macrophage Differentiation via SRC/LDHA Signaling in Early Pregnancy, Int J Biol Sci, 2022, Jan 1;18(2):599-616 PMID: 35002512
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Tenapanor

Catalog No. A14011
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NHE3 抑制剂

Tenapanor充当钠-质子交换器NHE3的抑制剂。这种抗转运蛋白在肾脏和肠道中发现，通常起到调节机体吸收和分泌的钠水平的作用。了解更多

Product Citations (8)

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- Xingjie Tan, .et al. The Na+/H+ exchanger NHE3 inhibitor tenapanor prevents intestinal obstructions in CFTR-deleted mice, Authorea, 2022, May 25
- Kunyan Zhou, .et al. Functional characterization of the sodium/hydrogen exchanger 8 and its role in proliferation of colonic epithelial cells, Am J Physiol Cell Physiol, 2021, Sep 1;321(3):C471-C488 PMID: 34288721
- Qinghai Tan, .et al. Inhibition of Na + /H + exchanger isoform 3 improves gut fluidity and alkalinity in cystic fibrosis transmembrane conductance regulator-deficient and F508del mutant mice, Br J Pharmacol, 2021, Mar;178(5):1018-1036 PMID: 33179259
- Y Liu, .et al. Deciphering Ion Transporters, Kinases and PDZ-adaptor Molecules That Mediate Guanylate Cyclase C Agonist-Dependent Intestinal Fluid Loss in Vivo, Biochem Pharmacol, 2020, May 16;178:114040 PMID: 32422138
- Yu Y, .et al. Expression, Localization and Functional Activity of the Major Na+/H+ Exchange Isoforms Expressed in the Intestinal Cell Line Caco-2BBe, Cell Physiol Biochem, 2019, 52(5):1017-1038 PMID: 30977986
- Thammayon N, .et al. Na+/H+ exchanger 3 inhibitor diminishes the amino-acid-enhanced transepithelial calcium transport across the rat duodenum, Amino Acids, 2017, Apr;49(4):725-734 PMID: 27981415
- Charoenphandhu N, .et al. Na+/H+ exchanger 3 inhibitor diminishes hepcidin-enhanced duodenal calcium transport in hemizygous β-globin knockout thalassemic mice, Mol Cell Biochem, 2017, Mar;427(1-2):201-208 PMID: 27995414
- Jantarajit W, .et al. CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels, Am J Physiol Cell Physiol, 2017, Jul 1;313(1):C118-C129 PMID: 28490422

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“azd”的搜索结果

AZD-3965

Tenapanor

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