“AG 490”的搜索结果

产品 51 到 100 共 3492个

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  1. BGC201531

    Catalog No. A22130
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    EP4 antagonist
    BGC201531, also known as GTPL3380 and AP-1531, is a EP4 antagonist for the treatment of acute migraine. 了解更多
  2. RGW 611

    Catalog No. A22135
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    anti-infective agent
    RGW 611, a morpholine derivative, is an impurity of Nimorazole, which is an anti-infective agent against anaerobic bacteria and protozoa. 了解更多
  3. MSA-2

    Catalog No. A22139
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    non-nucleotide STING agonist
    MSA-2, a potent and orally available non-nucleotide STING agonist, is bound to STING as a noncovalent dimer with nanomolar affinity. 了解更多
  4. Pyrimorph

    Catalog No. A22144
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    fungicide
    Pyrimorph is a fungicide with high activity against the plant pathogen Phytophthora capsici. 了解更多
  5. Soporidine

    Catalog No. A22145
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    strigolactone (SL) antagonist
    Soporidine is a strigolactone (SL) antagonist and inhibitor of germination in their biological assays. It binds AtHTL and specifically interferes with SL signaling. 了解更多
  6. AA41612

    Catalog No. A22147
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    antagonist of melanopsin-mediated phototransduction
    AA41612 is an antagonist of melanopsin-mediated phototransduction. 了解更多
  7. ERDRP-0519

    Catalog No. A22150
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    inhibitor of polymerase
    ERDRP-0519 is an orally available inhibitor of polymerase that shows efficacy against a lethal morbillivirus infection in a large animal model. 了解更多
  8. Nicomol

    Catalog No. A22154
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    antilipidemic agent
    Nicomol is a niacin derivative that exhibits antilipidemic activity. 了解更多
  9. Cetraxate Hydrochloride

    Catalog No. A22155
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    mucosal protective agent and an anti-ulcer drug
    Cetraxate (DV-1006) Hydrochloride (HCl) is a mucosal protective agent and an anti-ulcer drug candidate. Cetraxate raises levels of calcitonin gene-related peptide and substance P in human plasma. 了解更多
  10. Adenosine amine congener

    Catalog No. A22193
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    A1 adenosine receptor agonist
    Adenosine amine congener (ADAC) is a selective A1 adenosine receptor agonist, can ameliorate noise- and Cisplatin-induced cochlear injury. 了解更多
  11. Clobenpropit dihydrobromide

    Catalog No. A22263
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    histamine H3R antagonist/inverse agonist
    Clobenpropit dihydrobromide is a potent histamine H3R antagonist/inverse agonist with a pEC50 of 8.07 for histamine H3LR. 了解更多
  12. A 784168

    Catalog No. A22264
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    antagonist of Vanilloid receptor type 1
    A-784168 is a potent and selective antagonist of Vanilloid receptor type 1 (TRPV1). 了解更多
  13. 5-HT3 antagonist-4i

    Catalog No. A22265
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    5-HT3 receptor antagonist
    5-HT3 antagonist-4i is a 5-HT3 receptor antagonist which modulates the serotonergic system. 了解更多
  14. SR18662

    Catalog No. A22268
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    KLF5 inhibitor
    SR18662 is a potent inhibitor of Kr??ppel-like factor five (KLF5) with an IC50 of 4.4 nM and an analogue of ML264 (HY-19994) with improved inhibitory potency against colorectal cancer cells. SR18662 can be used for the study of colorectal cancer. 了解更多
  15. AUNP-12

    Catalog No. A22274
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    peptide antagonist
    AUNP-12 (NP-12) is a peptide antagonist of the PD-1 signaling pathway, displays equipotent antagonism toward PD-L1 and PD-L2 in rescue of lymphocyte proliferation and effector functions. 了解更多
  16. Motixafortide

    Catalog No. A22276
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    CXCR4 antagonist
    Motixafortide (BKT140 4-fluorobenzoyl) is a novel CXCR4 antagonist with an IC50 vakue of ??1 nM. 了解更多
  17. iFSP1

    Catalog No. A22277
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    glutathione-independent inhibitor
    iFSP1 is a potent, selective and glutathione-independent inhibitor of ferroptosis suppressor protein 1 (FSP1) (AIFM2) with an EC50 of 103 nM. 了解更多
  18. GMB475

    Catalog No. A22279
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    BCR-ABL1 tyrosine kinase degrader
    GMB-475 is a degrader of BCR-ABL1 tyrosine kinase based on PROTAC, overcoming BCR-ABL1-dependent drug resistance. 了解更多
  19. Ellagic acid (hydrate)

    Catalog No. A22282
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    ATP-competitive CK2 inhibitor
    Ellagic acid hydrate is a natural antioxidant, and acts as a potent and ATP-competitive CK2 inhibitor, with an IC50 of 40 nM and a Ki of 20 nM. 了解更多
  20. Tomatidine hydrochloride

    Catalog No. A22284
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    anti-inflammatory agent
    Tomatidine hydrochloride acts as an anti-inflammatory agent by blocking NF-κB and JNK signaling. Tomatidine hydrochloride activates autophagy either in mammal cells or C elegans. 了解更多
  21. Amarogentin

    Catalog No. A22286
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    bitter taste receptor TAS2R1 agonist
    Amarogentin (AG), a secoiridoid glycoside mainly extracted from Swertia and Gentiana roots, exhibits anti-oxidative, anti-tumour, and anti-diabetic activities. Amarogentin is an agonist for the bitter taste receptor TAS2R1 and inhibits in LAD-2 cells substance P-induced production of newly synthesized TNF-α. 了解更多
  22. Urolithin B

    Catalog No. A22287
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    regulator of skeletal muscle mass
    Urolithin B is one of the gut microbial metabolites of ellagitannins, and has anti-inflammatory and antioxidant effects. Urolithin B is also a regulator of skeletal muscle mass. 了解更多
  23. 3-Hydroxyanthranilic acid

    Catalog No. A22292
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    immunomodulatory agent
    3-Hydroxyanthranilic Acid (3-HAA, 3-HANA), a tryptophan metabolite, has an immunomodulatory effect that may result from inhibition of PI3K/Akt/mTOR and NF-κB activity, thereby decreasing the production of pro-inflammatory mediators. 了解更多
  24. Tomatine

    Catalog No. A22293
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    precipitating agent
    Tomatine is an glycoalkaloid that occurs in the extract of leaves of wild tomato plants. It has been found to inhibit the growth of various fungi and bacteria. It is used as a precipitating agent for steroids. 了解更多
  25. Acetosyringone

    Catalog No. A22294
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    anti-inflammatory agent
    Acetosyringone is a phenolic natural product with analgesic, antipyretic and anti-inflammatory actions. 了解更多
  26. SC-43

    Catalog No. A22295
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    SHP-1 (PTPN6) agonist
    SC-43, a Sorafenib derivative, is a potent and orally active SHP-1 (PTPN6) agonist. SC-43 inhibits the phosphorylation of STAT3 and induces cell apoptosis. SC-43 has anti-fibrotic and anticancer effects. 了解更多
  27. Dorzagliatin

    Catalog No. A22297
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    GK activator
    Dorzagliatin (HMS5552), a dual-acting glucokinase (GK) activator, improves glycaemic control and pancreatic β-cell function in type 2 diabetes. 了解更多
  28. Homosalate

    Catalog No. A22302
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    chemical UV filter
    Homosalate is an organic compound used in some sunscreens, it is used as a chemical UV filter, protecting the skin from sun damage. 了解更多
  29. Gallein

    Catalog No. A22304
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    Gβγ subunit signalling inhibitor
    Gallein is a G protein βγ (Gβγ) subunit signalling inhibitor. Gallein disrupts the interaction of Gβγ subunits with the PI3Kγ. Anticancer agent. 了解更多
  30. BDTX-189

    Catalog No. A22306
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    Anticancer agent
    BDTX-189 is a potent, orally active and selective inhibitor of allosteric EGFR and HER2 oncogenic mutations, including EGFR/HER2 exon 20 insertion mutants. BDTX-189 shows KDs of 0.2, 0.76, 13 and 1.2 nM for EGFR, HER2, BLK and RIPK2, reapectively. Anticancer activity. 了解更多
  31. Loureirin A

    Catalog No. A22313
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    flavonoid
    Loureirin A is a flavonoid extracted from Dragon's Blood, can inhibit Akt phosphorylation, and has antiplatelet activity. 了解更多
  32. Higenamine

    Catalog No. A22315
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    β2-AR agonist
    Higenamine (Norcoclaurine), a β2-AR agonist, is a key component of the Chinese herb aconite root that prescribes for treating symptoms of heart failure in the oriental Asian countries. 了解更多
  33. ABTL-0812

    Catalog No. A22321
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    antineoplastic agent
    ABTL-0812 (α-Hydroxylinoleic acid) induces endoplasmic reticulum (ER) stress-mediated autophagy. ABTL-0812 is a first-in-class small molecule with anti-cancer activity. 了解更多
  34. AG1557

    Catalog No. A22324
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    EGFR inhibitor
    AG1557 is a specific and ATP competitive inhibitor of epidermal growth factor receptor (EGFR) tyrosine kinase, has a pIC50 value of 8.194. 了解更多
  35. Decursinol angelate

    Catalog No. A22340
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    cytotoxic and protein kinase C (PKC) activating agent
    Decursinol angelate, a cytotoxic and protein kinase C (PKC) activating agent from the root of Angelica gigas, possesses anti-tumor and anti-inflammatory activities. 了解更多
  36. 3'-Hydroxypterostilbene

    Catalog No. A22341
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    natural pterostilbene analogue
    3'-Hydroxypterostilbene, a natural pterostilbene analogue, effectively inhibits the growth of human colon cancer cells (IC50s of 9.0, 40.2, and 70.9 ?M for COLO 205, HCT-116, and HT-29 cells, respectively) by inducing apoptosis and autophagy. 了解更多
  37. Dihydrocaffeic acid

    Catalog No. A22344
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    Antioxidant agent
    Dihydrocaffeic acid is a phenolic acid found in Gynura bicolor, reduces phosphorylation of MAPK p38 and prevent UVB-induced skin damage. Antioxidant potential and anti-inflammatory activity. 了解更多
  38. Pyridoxine

    Catalog No. A22350
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    antioxidant agent
    Pyridoxine (Pyridoxol) is a pyridine derivative. Pyridoxine exerts antioxidant effects in cell model of Alzheimer's disease via the Nrf-2/HO-1 pathway. 了解更多
  39. Nootkatone

    Catalog No. A22352
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    neuroprotective agent
    Nootkatone, a neuroprotective agent from Alpiniae Oxyphyllae Fructus, has antioxidant and anti-inflammatory effects. 了解更多
  40. Timosaponin AIII

    Catalog No. A22353
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    Inhibitor of U46619-induced Rat Platelet Aggregation
    Timosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways. 了解更多
  41. Beta-asarone

    Catalog No. A22354
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    neuroprotection agent
    Beta-Asarone, found in certain plants such as Acorus and Asarum, could pass the blood-brain barrier and exerts neuroprotection effects. 了解更多
  42. Coumarin-3-carboxylic Acid

    Catalog No. A22355
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    antiproliferative agent
    Coumarin-3-carboxylic acid (2- Oxochromene-3-carboxylic acid) is an important initial compound for the synthesis of coumarins which are well known natural products for their diverse biological activities. Lanthanide complexes of Coumarin-3-carboxylic acid exhibit antiproliferative activity towards K-562 cell line. 了解更多
  43. (2S,3R,4S)-4-Hydroxyisoleucine

    Catalog No. A22356
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    anti-diabetes agent
    (2S,3R,4S)-4-Hydroxyisoleucine is an orally active compound isolated from Trigonella foenum-graecum, with anti-diabetes and anti-diabetic nephropathy activity. 了解更多
  44. Solamargine

    Catalog No. A22357
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    anticancer agent
    Solamargine, a derivative from the steroidal solasodine in Solanum species, exhibits anticancer activities in numerous types of cancer. Solamargine induces non-selective cytotoxicity and P-glycoprotein inhibition. 了解更多
  45. Skatole

    Catalog No. A22359
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    bacteriostatic agent
    Skatole (3-methylindole, Scatole) is a mildly toxic white crystalline organic compound that occurs naturally in feces. It has a fairly broad bacteriostatic effect.. 了解更多
  46. 3BDO

    Catalog No. A22360
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    mTOR activator
    3BDO is a new mTOR activator which can also inhibit autophagy. 了解更多
  47. BMP signaling agonist sb4

    Catalog No. A22362
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    BMP4 signaling agonist
    BMP signaling agonist sb4 is a potent benzoxazole bone morphogenetic protein 4 (BMP4) signaling agonist with a EC50 value of 74 nM, activates BMP signaling by stabilizing intracellular p-SMAD-1/5/9. 了解更多
  48. Pemafibrate

    Catalog No. A22201
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    PPAR alpha agonist
    Pemafibrate, also known as (R)-K 13675, is a PPAR alpha agonist. 了解更多
  49. Avacopan

    Catalog No. A22202
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    selective C5aR antagonist
    Avacopan (CCX168) is an orally administered and selective C5a receptor (C5aR) antagonist. 了解更多
  50. Perlapine

    Catalog No. A22204
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    hM3Dq DREADD agonist
    Perlapine is a potent and selective hM3Dq DREADD agonist (EC50 = 2.8 nM). This drug exhibits >10,000-fold selectivity for hM3Dq over hM3. 了解更多

产品 51 到 100 共 3492个

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