“betaine hydrochloride”的搜索结果
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monoamine oxidase A inhibitor
Clorgyline hydrochloride is an irreversible and selective inhibitor of monoamine oxidase A (MAO-A) that is used in scientific research; structurally related to Pargyline.
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5-HT2 antagonist
Sarpogrelate hydrochloride (MCI-9042), a selective 5-HT2 antagonist, has been widely used as an anti-platelet agent for the treatment of PAD.
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5-HT (serotonin)/dopamine receptor antagonist
Ziprasidone Hcl(CP-88059 Hcl) is a combined 5-HT (serotonin) and dopamine receptor antagonist which exhibits potent effects of antipsychotic activity.
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Kir2 family channels inhibitor
ML133 hydrochloride is a selective Kir2 family channels inhibitor, with an IC50 of 1.8 μM at pH 7.4 and 290 nM at pH 8.5.
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5-HT6 receptor antagonist
SB271046 Hydrochloride is a potent, selective and orally active 5-HT6 receptor antagonist with pKi of 8.9.
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VEGFR1/2/3/PDGFRβ/Kit/RET/Raf-1 inhibitor
Regorafenib Hydrochloride is a multi-target inhibitor for VEGFR1/2/3, PDGFRβ, Kit, RET and Raf-1 with IC50s of 13/4.2/46, 22, 7, 1.5 and 2.5 nM, respectively.
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TRP Channel blocker
SKF-96365 hydrochloride is a non-selective TRP Channel blocker.
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PAD4 inhibitor
GSK484 hydrochloride (GTPL8577) is a selective and reversible peptidylarginine deiminase 4 (PAD4) inhibitor.
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PEPCK inhibitor
SKF-34288 hydrochloride (3-Mercaptopicolinic acid) is a phosphoenolpyruvate carboxykinase (PEPCK) inhibitor. SKF-34288 hydrochloride is a potent hypoglycemic agent via inhibition of glucose synthesis through the specific inhibition of PEPCK in the gluconeogenesis pathway.
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N-Acetylputrescine hydrochloride is a putrescine derivative.
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calcium channel blocker
Bepridil hydrochloride (CERM 1978) is a calcium channel blocker, with antianginal activity.
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K+/Na+/Ca+ Channel Blocker
Dronedarone Hydrochloride is a non-iodinated amiodarone derivative that inhibits Na+, K+ and Ca2+ currents.
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β-adrenergic receptor antagonist
Metipranolol (hydrochloride) is a non-selective β-adrenergic receptor (β-AR) antagonist. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
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Belotecan, also known as CKD-602, is the semi-synthetic camptothecin analogue belotecan with potential antitumor activity.
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5-HT1A receptor antagonist
Alprenolol (hydrochloride) is a non-selective beta blocker as well as 5-HT1A receptor antagonist.
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BChE inhibitor
Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM.
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anti-inflammatory
Amodiaquine hydrochloride is a 4-aminoquinoquinoline compound with anti-inflammatory properties.
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antineoplastic agent
Nimustine hydrochloride is an antineoplastic agent especially effective against malignant brain tumors. The resistance which brain tumor cells acquire to the initial effectiveness of this drug can be partially overcome by the simultaneous use of membrane-modifying agents such as reserpine, calcium antagonists such as nicardipine or verapamil, or the calmodulin inhibitor, trifluoperazine.
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anti-microbial
Cefotetan Hydrochloride is a second-generation cephalosporin that is active against some strains of β-lactamase producing bacteria. It shows anti-microbial activity against Gram-positive and Gram-negative bacteria; it is more efficacious against Gram-negative and anaerobic bacteria
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TNF receptor inhibitor
AX-024 is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1 nM). Inhibiting an immediate TCR signal has promise for treating a broad spectrum of human T cell-mediated autoimmune and inflammatory diseases.
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Muscarinic antagonist
Procyclidine hydrochloride is a muscarinic antagonist that crosses the blood-brain barrier and is used in the treatment of drug-induced extrapyramidal disorders and in Parkinsonism.
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alpha-1 adrenergic agonist
Methoxamine Hydrochloride is an alpha-1 adrenergic agonist that causes prolonged peripheral vasoconstriction.
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nicotinic receptor agonist
Lobeline hydrochloride, a nicotinic receptor agonist, acting as a potent antagonist at both α3β2 and α4β2 neuronal nicotinic receptor subtypes.
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Bcl-xL 抑制剂
WEHI-539 hydrochloride是BCL-xL的小分子抑制剂,IC50值为1.1 nM。
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SR9011是REV-ERB-α(IC50为670 nM)和REV-ERB-β(IC50为800 nM)的激动剂。
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SphK2 抑制剂
K145 hydrochloride是选择性鞘氨醇激酶2(SphK2)抑制剂和抗癌剂。
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JAK2 抑制剂
NS-018 hydrochloride是一种新型的高选择性JAK2抑制剂。
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TGF-beta 激动剂
SRI-011381 hydrochloride是一种TGF-β信号传导激动剂。
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dopamine D2 receptor 激动剂
UNC 9994 hydrochloride,独特的,β-arrestin偏向的功能选择性多巴胺D2受体(D2R)激动剂(Ki值为30 nM;在ε-arrestin-2募集试验中EC50值为50 nM),在体内具有抗精神病活性。UNC9994在野生型小鼠中显着抑制了PCP诱导的超运动,而在Δr-arrestin-2基因敲除小鼠中这种作用被完全消除。
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- Anika Mann, .et al. New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D 2 receptor regulation and signaling, Sci Rep, 2021, Apr 15;11(1):8288 PMID: 33859231
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LRRK2 抑制剂
CZC54252 hydrochloride是一种有效的LRRK2抑制剂,野生型和G2019S LRRK2的IC50分别为1.28 nM和1.85 nM。
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AMPA 拮抗剂
YM90K hydrochloride是一种选择性AMPA受体拮抗剂,在局部缺血后给药后,可延迟整体缺血模型中的神经元死亡和局部缺血模型中的脑梗塞。
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Ion channel blocker
Vernakalant hydrochloride是一种研究性混合离子通道阻滞剂,可以以2至5 mg/kg的剂量终止人的急性心房纤颤(AF),并且与现有药物相比,对房颤的选择性更高。在抗心律不齐的治疗中。
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- Joe Z.Zhang, .et al. A Human iPSC Double-Reporter System Enables Purification of Cardiac Lineage Subpopulations with Distinct Function and Drug Response Profiles, Cell Stem Cell, 2019, 24, 1-10
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ST-836 hydrochloride是多巴胺受体配体;反帕金森氏剂。
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PI3K 抑制剂
PI-103 Hydrochloride是对重组PI3K亚型p110alpha(IC50 = 2 nM),p110beta(IC50 = 3 nM),p110delta(IC50 = 3 nM)和p110gamma(IC50 = 15 nM)具有低IC50值的有效抑制剂,对mTOR的效力较低/DNA-PK,IC50为30 nM/23 nM。
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SE 抑制剂
NB-598 hydrochloride是角鲨烯环氧酶(SE)的有效竞争性抑制剂。NB-598 hydrochloride通过法尼醇途径抑制甘油三酸酯的生物合成。
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CaMK-II 抑制剂
KN-92 hydrochloride是KN-93的阴性对照。
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nAChR 抑制剂
EVP-6124 hydrochloride是一种新型的α7神经元烟碱型乙酰胆碱受体(nAChRs)的部分激动剂。EVP-6124对α7nAChRs具有选择性,并且不激活或抑制异源α4β2nAChRs。
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Raf 抑制剂
CEP-32496 hydrochloride是野生型BRAF,V600E突变型BRAF和c-Raf的高效抑制剂,Kd值分别为14 nM,36 nM和39 nM。
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Chk2 抑制剂
CCT241533 hydrochloride是一种有效的丝氨酸/苏氨酸检查点激酶(Chk2)抑制剂,IC50为3 nM;显示在1 uM下与一组激酶的交叉反应最小。
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JNK 抑制剂
CC-401 hydrochloride是具有潜在抗肿瘤活性的第二代ATP竞争性蒽并吡喃酮c-Jun N末端激酶(JNK)抑制剂。
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imidazoline receptor 1 激动剂
Moxonidine Hydrochloride (BDF5895)是咪唑啉1型受体(I1-R)选择性激动剂,为降压剂。
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GPIIb/IIIa 拮抗剂
Tirofiban Hydrochloride Hydrate是一种特定的非肽血小板纤维蛋白原受体(GPIIb/IIIa)拮抗剂。
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5-HT1A receptor 拮抗剂
NAD 299 hydrochloride (Robalzotan)是一种选择性的,高亲和力的5-HT1A受体拮抗剂(体外Ki = 0.6 nM)。
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serotonin 2C receptor 激动剂
lorcaserin hydrochloride (APD-356)是血清素2C受体激动剂,可指示与减少热量饮食和增加体育锻炼以减轻慢性体重成人管理。
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- Li Li, .et al. Delineating a serotonin 1B receptor circuit for appetite suppression in mice, J Exp Med, 2022, Aug 1;219(8):e20212307 PMID: 35796804
- Henrik H. Hansen, .et al. Whole-brain activation signatures of weight-lowering drugs, Mol Metab, 2021, May;47:101171 PMID: 33529728
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PARP 抑制剂
PJ 34 hydrochloride是聚(ADP-核糖)聚合酶(PARP)(EC50 = 20 nM)的有效抑制剂。
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- Alvin Z.Lu, .et al. Enabling drug discovery for the PARP protein family through the detection of mono-ADP-ribosylation, Biochem Pharmacol, 2019, May 7. pii: S0006-2952(19)30171-6 PMID: 31075269
- Wigle TJ, .et al. Forced Self-Modification Assays as a Strategy to Screen MonoPARP Enzymes, SLAS Discov, 2019, Dec 19:2472555219883623 PMID: 31855104
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5-HT2/5-HT1 拮抗剂
Mianserin hydrochloride是5-HT2/5-HT1拮抗剂。对5-HT6非选择性5-HT2受体拮抗剂具有中等亲和力。对5-HT6具有中等亲和力。
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negative control compound
GSK106 is a negative control compound that can be used in binding and functional assays for PAD4 inhibitors.
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β-adrenergic receptor (βAR) antagonist
(R)-Propranolol hydrochloride is a less active enantiomer of the β-adrenoceptor antagonist propranolol (HY-B0573). Propranolol is a nonselective β-adrenergic receptor (βAR) antagonist, has high affinity for the β1AR and β2AR with Ki values of 1.8 nM and 0.8 nM, respectively.
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dual c-Met/Ron inhibitor
MK8033 Hcl is a novel and specific dual ATP competitive c-Met/Ron inhibitor (IC50=1 nM Wt c-Met) under investigation as a treatment for cancer.
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NMDA ion-channel antagonist
CNS-5161 hydrochloride is a novel NMDA ion-channel antagonist that interacts with the NMDA receptor/ion channel site to produce a noncompetitive blockade of the actions of glutamate.
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