“Tutalthromycin second gen”的搜索结果
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NMDA receptor agonist
Quinolinic acid is an endogenous N-methyl-D-aspartate (NMDA) receptor agonist synthesized from L-tryptophan via the kynurenine pathway and thereby has the potential of mediating N-methyl-D-aspartate neuronal damage and dysfunction.
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Dansyl glutathione is a trapping agent for the quantitative estimation and identification of reactive metabolites.
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sulfo-SPDB-DM4 is a drug-linker conjugate for ADC by using the maytansinebased payload (DM4, an antitubulin agent) via the sulfo-SPDB linker.
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antitubulin agent
MMAF-Ome, an antitubulin agent, belongs to ADC.
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Linaprazan (AZD0865) inhibits gastric H+,K+-ATPase by K+-competitive binding. (IC50: 1.0 ± 0.2 μM) It is a acid-suppressing agents with rapid onset of action and potent acid inhibition.
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IDO inhibitor
IDO-IN-1 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor with an IC50 of 59 nM.
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NO inhibitor
SDMA (Symmetric dimethylarginine) is an endogenous inhibitor of nitric oxide (NO) synthase activity.
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uPA system inhibitor
UKI-1 is a novel synthetic inhibitor of the urokinase-type plasminogen activator system.
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2-(Methylamino)-1H-purin-6(7H)-one (N2-Methylguanine) is a modified nucleoside. 2-(Methylamino)-1H-purin-6(7H)-one is an endogenous methylated nucleoside found in human fluids.
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AhR activator
Mivotilate is a nontoxic, potent activator of the aryl hydrocarbon receptor (AhR), and acts as a hepatoprotective agent.
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DHBP dibromide is an inhibitor for calcium release and a muscle relaxant.
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NO synthase inhibitor
Agmatine sulfate exerts modulatory action at multiple molecular targets, such as neurotransmitter systems, ion channels and nitric oxide synthesis. It is an endogenous agonist at imidazoline receptor and a NO synthase inhibitor.
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cholesterol-lowering agent
TA-7552 is a potent cholesterol-lowering agent.
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(-)-(S)-Equol is a high affinity ligand for estrogen receptor β with a Ki of 0.73 nM.
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plasminogen activator inhibitor
TM5275 sodium is a plasminogen activator inhibitor (PAI-1) with an IC50 of 6.95 μM.
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Y-9738 is a hypolipidemic agent.
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ERRβ agonist
WAY-200070 is a selective estrogen receptor β (ERRβ) agonist with an IC50 of 2.3 nM.
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ER antagonist
Nitromifene is an antagonist of estrogen receptor (ER).
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GCN2 inhibitor
GCN2-IN-1 (A-92) is a potent general control nonderepressible 2 kinase (GCN2) inhibitor with an IC50 of <0.3 μM in the enzyme assay and an IC50 of 0.3-3 μM in the cell assay.
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Xenalamine is a synthetic antiviral agent.
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B220 is an antiviral agent which can inhibit the growth of HSV-1, HSV-2 and human cytomegalovirus (CMV).
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microtubule-depolymerizing agent
MPT0B392 is demonstrated to be a novel microtubule-depolymerizing agent and enhances the cytotoxicity of sirolimus in sirolimus-resistant acute leukemic cells and the multidrug resistant cell line.
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RMI 10874 is a tilorone analogue. Tilorone is a small-molecule, orally bioavailable antiviral agent. RMI 10874 completely abolishes lung colonization of an H-2 negative (GR9.B9) MCA-induced fibrosarcoma clone.
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TxA2 synthetase inhibitor
CGS 15435, a potent thromboxane (TxA2) synthetase inhibitor with an IC50 of 1 nM, has a selectivity for Tx synthetase 100000-fold greater than that for cyclooxygenase, PGI2 synthetase and lipoxygenase enzymes.
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9-Propenyladenine is a mutagenic impurity in tenofovir disoproxil fumarate. Tenofovir is an antiretroviral drug known as nucleotide analogue reverse transcriptase inhibitors, which block reverse transcriptase, a crucial virus enzyme in HIV-1 and HBV.
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Thiazolidinone-Derivatives-1 is an antiulcer agent which inhibits the secretion of gastric acid.
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MDL 19301 is a nonsteroidal, anti-inflammatory agent.
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FT011 is an anti-fibrotic agent, reduces mRNA expression of collagens I and III and inhibits collagen synthesis.
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Nox4 inhibitor
GLX351322 is an inhibitor of NADPH oxidase 4 (Nox4), and inhibits hydrogen peroxide production from NOX4-overexpressing cells with an IC50 of 5 μM.
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MF 5137 is a potent antibacterial agent.
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LDHA inhibitor
GSK2837808A is a potent and selective lactate dehydrogenase A (LDHA) inhibitor with IC50s of 1.9 and 14 nM for LDHA and LDHB, respectively.
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Droxicainide is an antiarrhythmic agent.
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Antifungal agent 1 is a potent antifungal agent.
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Diphenylterazine is a bioluminescence agent.
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DUPA(OtBu)-OH is a DUPA precursor. DUPA is used as the targeting moiety to actively deliver Docetaxel (DTX) for treatment of Prostate-Specific Membrane Antigen (PSMA) expressing prostate cancer.
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anti-tuberculosis agent
TBAJ-587, a potent anti-tuberculosis agent, inhibits M.tb strain H37Rv growth with MIC90s of 0.006 and <0.02 ?g/mL in MABA and LORA assay, respectively.
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STING activator
CL656 is an activator of stimulator of interferon genes (STING).
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JAK inhibitor
JAK-IN-4 is a prodrug of a JAK inhibitor, effective in murine collagen induced arthritis model.
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Rilmazafone is a water-soluble benzodiazepine prodrug that acts as a sedative and hypnotic neuropsychiatric agent.
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AR antagonist
UT-155 is a selective and potent androgen receptor (AR) antagonist, with a Ki of 267 nM for UT-155 binding to AR-LBD.
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Oral antiplatelet agent 1 is a potent antiplatelet agent with an IC50 of 2.94 μM in vitro as well as antithrombotic efficacy in a rat model. P2Y receptor antagonist.
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GGT inhibitor
GGsTop (Nahlsgen) is a potent, non-toxic, highly selective and irreversible γ?glutamyl transpeptidase (GGT) inhibitor, with a Ki of 170 μM for Human GGT.
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DIQ3 is a potent anti-cancer agent, nontoxic to normal human cell lines.
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Letrazuril is an anti-HIV agent.
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5α-Pregnane-3β,6α-diol-20-one is a mitogenic metabolite of progesterone, and it can be produced in starved androgen-responsive prostate cancer cells.
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antiinflammatory agent
Losmiprofen is a nonsteroidal antiinflammatory agent.
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lipid-lowering agent
Gemcabene (PD-72953), a first-in-class lipid-lowering agent.
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AP5 exhibits potent and selective agonism for the GPR40 receptor with positive allosteric modulation of endogenous ligands (AgoPAM). AP5 demonstrates a rat hIP1 EC50 of 0.49±0.28 nM against the GPR40 receptor.
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Androgen receptor partial agonist
YK11 is a partial agonist of androgen receptor, with osteogenic activity.
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Aspartyl-alanyl-diketopiperazine (DA-DKP) is an immunomodulatory molecule generated by cleavage and cyclization from the N-terminus of human albumin and can modulate the inflammatory immune response through a molecular pathway implicated in T- lymphocyte anergy.
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