Cytochrome P450

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Seviteronel

Catalog No. A20996
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CYP17 lyase inhibitor

Seviteronel (VT-464) is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM) that demonstrated both exceptional in vitro lyase/hydroxylase selectivity (~10-fold) and oral activity in a hamster model of androgen biosynthesis inhibition. 了解更多

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Veledimex

Catalog No. A21011
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CYP3A4/5 inhibitor and substrate

Veledimex is an oral activator ligand for a proprietary gene therapy promoter system, and a moderate inhibitor of and substrate for CYP3A4/5. 了解更多

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Bergaptol

Catalog No. A12303
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CYP3A4 enzyme inhibitor

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM. Recent studies suggest that it may have antiproliferative and anticancer properties. 了解更多

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CYP17-IN-1

Catalog No. A12622
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CYP17 inhibitor

CYP17-IN-1 (compound 9c) is a potent and orally active CYP17 inhibitor against rat and human CYP17 with IC50s of 15.8 and 20.1 nM. 了解更多

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Sulfaphenazole

Catalog No. A17283
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CYP2C9 inhibitor

Sulfaphenazole is a specific inhibitor of CYP2C9 which blocks atherogenic and pro-inflammatory effects of linoleic acid (increase in oxidative stress and activation of AP-1) mediated by CYP2C9. 了解更多

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Efavirenz

Catalog No. A15826
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cytochrome P450 抑制剂

Efavirenz是一种非核苷类逆转录酶抑制剂（NNRTI）。了解更多

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Talarozole R enantiomer

Catalog No. A13113
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Cytochrome P450 抑制剂

Talarozole R enantiomer 通过阻断细胞色素P450酶同工酶CYP26（一种视黄酸羟化酶）来抑制视黄酸的代谢。了解更多

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Haloperidol (Haldol)

Catalog No. A10446
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CYP2D6 抑制剂

Haloperidol (Haldol)是一种抗精神病药和丁二酮。了解更多

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Clarithromycin

Catalog No. A10225
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cytochrome P4503A4 抑制剂

Clarithromycin是一种大环内酯类抗生素。它通过干扰细菌的蛋白质合成来防止细菌生长。了解更多

Product Citations (4)

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- Reiko Watanabe, .et al. Development of an In Silico Prediction Model for P-glycoprotein Efflux Potential in Brain Capillary Endothelial Cells toward the Prediction of Brain Penetration, J Med Chem, 2021, Mar 11;64(5):2725-2738 PMID: 33619967
- Takashi Azuma, .et al. Removal of pharmaceuticals in water by introduction of ozonated microbubbles, SEP PURIF TECHNOL, 2019, Apr; 212: 483-489
- Azuma T, .et al. Distribution of six anticancer drugs and a variety of other pharmaceuticals, and their sorption onto sediments, in an urban Japanese river, Environ Sci Pollut Res Int, 2017, Aug;24(23):19021-19030 PMID: 28660504
- Azuma T, .et al. Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents, Sci Total Environ, 2016, Apr 1;548-549:189-197 PMID: 26802347