Epigenetics

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  1. DL-AP3

    Catalog No. A15378
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    mGluR1 拮抗剂
    DL-AP3是D-AP3和L-AP3的外消旋制剂,是磷酸丝氨酸磷酸酶的抑制剂和代谢型谷氨酸受体(mGluR)的拮抗剂,阻断了由mGluR介导的磷酸肌醇转换。 了解更多
  2. WDR5-0103

    Catalog No. A15928
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    WDR5 拮抗剂
    WDR5-0103是一个小分子,可与WDR5上的肽结合袋结合(Kd = 450 nM),在体外抑制MLL核心复合物的催化活性(IC50 = 39 M)。 了解更多
  3. UNC3866

    Catalog No. A11599
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    CBX4 /CBX7 chromodomains 拮抗剂
    UNC3866是CBX4和CBX7色域的有效拮抗剂,每个Kd约为100 nM,与其他七个CBX和CDY色域相比,其选择性是6至18倍。 了解更多
  4. Flopropione

    Catalog No. A16550
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    5-HT1A receptor antagonist/COMT inhibitor
    Flopropione是5-HT1A受体拮抗剂,也是儿茶酚-邻甲基转移酶(COMT)抑制剂。 了解更多
  5. OICR-9429

    Catalog No. A16641
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    Wdr5-MLL interaction antagonist
    OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction with IC50 of 5 uM. inhibit proliferation and induce differentiation . 了解更多
  6. OICR-0547

    Catalog No. A20877
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    Wdr5-MLL interaction antagonist
    OICR-0547 is a closely related derivative of OICR-9429. OICR-9429 is a novel small-molecule antagonist of the Wdr5-MLL interaction, while OICR-0547 cannot bind to WDR5. 了解更多
  7. PRI-724

    Catalog No. A15856
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    CBP/beta-catenin 拮抗剂
    PRI-724是ICG-001的异构体或对映异构体,是一种强力的特异性抑制剂癌症干细胞中的Wnt信号通路具有潜在的抗肿瘤活性。 了解更多
  8. Reversine

    Catalog No. A13250
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    human A3 adenosine receptor 拮抗剂 /Aurora 抑制剂
    Reversine是一种有效的人A3腺苷受体拮抗剂,Ki为0.66μM,是一种泛光A/B/C激酶抑制剂,IC50分别为12 nM/13 nM/20 nM。也用于干细胞去分化。 了解更多

8 个项目

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